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Biomedical subjects

M J Freeman

Publications and source records attributed to M J Freeman.

7 recordsLinked to original sources
PubMed1979

Effects of age on cellular immune responses in BALB/cJ mice: increase in antibody-dependent T lymphocyte mediated cytotoxicity.

Two in vitro cell-mediated immune (CMI) responses of splenic lymphocytes of BALB/cJ mice of various ages (1.25, 2.5, 4, 10.5 and 30 months) were examined. These were the antibody-dependent lymphocyte-mediated cytotoxicity (ADLMC) responses, mediated by the K cell subclass to T lymphocytes, and phytohemagglutinin (PHA) induced mitogenesis, mediated by the theta positive T lymphocytes. ADLMC responses increased with age, culminated at 10.5 months, then slowly declined. Lymphocytes of young mice (2.5 or 4 months of age) were significantly more responsive to PHA than lymphocytes of mature (10.5 months) or aged adults (30 months) (p less than 0.01), indicating progressive suppression of this type of CMI response with age, as observed previously. The difference in time of maturation and extent of suppression of ADLMC and PHA responses was not influenced by changes in numbers of specific effector cells, since percentages of these did not change with age (as measured by immunofluorescence and rosetting techniques). The increase with age of ADLMC responses may be due to deregulation of earlier suppressor activity which allows the K cell to be fully responsive, but other mechanisms may be involved.

Aging↗
PubMed1979

DermRx. An experiment in computerizing information on dermatologic therapy.

The Task Force for Creating a Biomedical Communications System for Dermatology was commissioned by the American Academy of Dermatology to develop an experimental segment of a computerized data bank on dermatologic therapy. The Task Force has completed such a "first generation" system and has named it DermRx. Its data bank carries the following information on each entry: the name of the disease; topical, systemic, physical, and other kinds of treatment; caveats; references to the literature; and the date and reviewer(s). The DermLit and DermRx programs are two components of a projected broader concept of an eventual comprehensive Biomedical Communications System for Dermatology. Such a system is envisaged as a means of making available to dermatologists diverse data relevant to practice, teaching, research, and business aspects of the specialty. At the moment, access to the stored information on dermatologic literature and therapy is by telephone call to, or by correspondence with, the central computer facility at Northwestern University. Eventually it is projected to be accessible by dedicated microcomputers housed in the physician's office. This preliminary report on DermRx is presented to review the progress of the project to date and to elicit comment upon its structure and value.

Dermatology↗
PubMed1978

Histiocytic medullary reticulosis presenting as Mucha-Habermann disease.

Histiocytic medullary reticulosis (HMR) is a rare, progressive, fatal reticuleondothelial proliferative disorder. It was diagnosed in a 10-year-old boy who had pityriasis lichenoides et varioliformis acuta of Mucha-Haberman which was controlled by dapsone for 2 years. One month after cessation of dapsone therapy, cutaneous tumors associated with fever, lymphadenopathy, and hepatosplenomegaly developed. Tissue biopsy specimens of skin, liver, spleen, lymph nodes, and a bone marrow aspirate demonstrated histiocytic erythrophagocytosis and atypical histiocytosis compatible with HMR. A rapidly progressing, fatal course followed despite intensive chemotherapy.

Child↗
PubMed1977

Glycolipid-bound sialic acid in serum: increased levels in mice and humans bearing mammary carcinomas.

In mice bearing transplantable mammary carcinomas, serum levels of sialic acid-containing glycolipids were elevated 2.5-fold in pooled serum samples from which gangliosides were purified by column chromatography. A method is also described by which ganglioside content was estimated on as little as 1.0 ml of whole blood to permit studies with individual tumor-bearing mice and age- and litter-matched controls. Using this method, we observed similar elevations in ganglioside levels that were independent of age and sex of the animal and appeared in advance of palpable tumors. Following excision of the tumors, the glycolipid sialic acid values dropped below control levels and remained there. Serum sialic acid of the glycolipid fraction was elevated nearly 2-fold in human carcinoma patients and appeared to decline after surgery.

Animals↗
PubMed1977

Skin diseases of football and wrestling participants.

This discussion has highlighted some of the cutaneous disorders that are found in football and wrestling participants in an exaggerated form. These disorders may occur in any person, of course, and are not limited to football or wrestling participants. Also, football and wrestling participants may have any cutaneous disorder; their disorders are not limited to those mentioned in this review. The dermatologist should be alert to contagous disorders in these participants, especially because of the close contact their activities necessitate and the potential epidemic spread of these disorders. One must also be alert to the possibility that a condition may be masked by the minor trauma of the sport. It is re-emphasized that these disorders are exaggerated because of the increased perspiration, heat, friction, secretion of fatty acids, body contact, special gear, climatic conditions, and trauma. Fortunately, the participants are normally healthy individuals who respond quickly to the appropriate therapy.

Acne Vulgaris↗