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Biomedical subjects

M J Dillon

Publications and source records attributed to M J Dillon.

At least 163 records · Page 9Linked to original sources
PubMed1985

Platelet immune complex interaction in pathogenesis of Kawasaki disease and childhood polyarteritis.

The role of platelets in the pathogenesis of vasculitis and the formation of coronary artery aneurysms was studied in 19 children with Kawasaki disease and five with polyarteritis. All patients with Kawasaki disease developed thrombocytosis in the third week of illness. The peak platelet count was significantly correlated (p less than 0.005) with the subsequent development of coronary artery aneurysms. The rise in platelet count was associated with the appearance in the circulation of a factor that induced aggregation and serotonin release in normal platelets. This factor was shown to be of high molecular weight, and its activity was lost at low pH--features suggestive of an immune complex. Immune complexes, detected by precipitation with polyethylene glycol, also appeared in the circulation as the platelet count increased. These complexes induced platelet aggregation, and there was a significant correlation (p less than 0.001) between the concentrations of IgG and IgA in the polyethylene glycol precipitated material and the platelet aggregating activity. Similar platelet aggregating activity was also detected in patients with polyarteritis but followed a different time course, persisting in the circulation for several months in association with continued disease activity. These findings imply that different mechanisms have a role in distinct phases of Kawasaki disease. The initial feverish phase (probably infective) is probably followed by an immune complex vasculitis that occurs when antibodies to the initiating agent appear in the circulation. The immune complexes aggregate platelets and induce release of serotonin. Platelet derived vasoactive mediators may increase vascular permeability and facilitate further deposition of complexes in the tissues.

Aneurysm↗
PubMed1985

Isolated glucocorticoid deficiency: metabolic and endocrine studies in a 5-year-old boy.

A 5-year-old boy is described who presented with episodes of hypoglycaemia triggered by mild infections or fever. Subnormal glucocorticoid production was confirmed by demonstrating low urinary excretion of free cortisol, low plasma cortisol concentrations that did not rise after glucagon and ACTH stimulation, and by elevated plasma ACTH levels. The selective nature of the abnormality was confirmed by demonstrating normal plasma electrolyte concentrations and blood pressure on a salt-restricted diet. Plasma renin activity and plasma aldosterone levels were also normal and responded appropriately to salt restriction and to frusemide-induced diuresis. Starvation-induced hypoglycaemia was associated with raised levels of blood ketone bodies and low blood alanine concentrations. Catecholamine secretion during hypoglycaemia was reduced. Glucocorticoid replacement therapy was effective in restoring normal glucose homeostasis.

Acidosis↗
PubMed1985

Brain revascularisation in hypertension.

Neurological symptoms in hypertensive subjects may be a reflection of intracranial vascular disease and not just a consequence of hypertension. Two hypertensive children with renovascular disease, neurological symptoms, and severe cerebral arterial disease were treated by extracranial-intracranial arterial bypass surgery with improvement of symptoms and easier control of blood pressure. Where revascularisation surgery is appropriate, this should be undertaken before neurological complications arise.

Arterial Occlusive Diseases↗
PubMed1985

Raynaud's disease.

We report five children who presented with Raynaud's disease in whom we could find no clinical, haematological, or immunological evidence of a collagen disorder. Oral phenoxybenzamine proved useful for maintenance treatment in most, with infusions of prostacyclin, nitroprusside, and ketanserin during acute attacks.

Antihypertensive Agents↗
PubMed1985

Toxic shock syndrome.

Presenting features and clinical manifestations of six patients with toxic shock syndrome are reported. In four of the six cutaneous injury, sometimes trivial, occurred before the onset of symptoms and may have been a causal factor. All six children recovered. The need for early recognition and intensive management in this life threatening condition is discussed.

Anti-Bacterial Agents↗
PubMed1985

Tubular proteinuria in children without other defects of renal function.

3 patients are described in whom proteinuria was detected on routine urine analysis and subsequently shown to be predominantly tubular in origin. Renal biopsies showed only minor changes. Hypercalciuria was also noted in 1 of the 3 patients but no other tubular abnormalities were demonstrated. The precise diagnosis remains uncertain, but an unusual presentation of idiopathic hypercalciuria or of the adult Fanconi syndrome must be considered. These patients may alternatively have a previously undescribed disorder.

Calcium↗
PubMed1984

Comparison of aortography, renal vein renin sampling, radionuclide scans, ultrasound and the IVU in the investigation of childhood renovascular hypertension.

The results of the investigations of all patients who underwent renal arteriography for hypertension due to renovascular disease over a three and a quarter year period prior to January 1st 1981 are reviewed and discussed. The experience gained has helped demonstrate the usefulness of DMSA scans, segmental renal vein renin estimations, and AP and oblique selective renal arteriograms with macroradiography.

Adolescent↗
PubMed1983

Comparison of prostaglandin production of skin fibroblasts grown from patients with Bartter's syndrome and from age and sex matched controls.

Basal and bradykinin stimulated release of prostaglandins (6-oxo-PGF1 alpha, PGF2 alpha, PGE2) and of arachidonic acid (C20:4) from skin fibroblast cultures of two patients with Bartter's Syndrome were compared with age and sex matched controls. PG-formation from 14C-C20:4 was studied, and for PGE2 a radioimmunoassay was also employed. The data show that in basal release, Bartter's Syndrome fibroblasts produce significantly less PGE2 than controls. Stimulated release of 6-oxo-PGF1 alpha was higher, that of PGE2 lower and that of C2O:4 higher in Bartter's Syndrome than in controls, all differences being significant. Despite equal culturing conditions the estimated intracellular potassium was higher in the patients fibroblasts than in controls. In skin fibroblasts from patients with Bartter's Syndrome stimulated prostaglandin production from C2O:4 is mostly depressed, with the exeption of prostacyclin which is enhanced. The permeability of cell membranes for potassium might play a pathogenetic role.

6-Ketoprostaglandin F1 alpha↗
PubMed1983

Fetal urinary tract obstruction: is active intervention before delivery indicated?

Obstruction of the urinary tract was diagnosed by ultrasound in four fetuses at 16-30 weeks: three of these diagnoses were confirmed after delivery; the fourth fetus had multicystic kidneys with hydroureter and hydronephrosis but no obstruction. The fetus with obstruction diagnosed at 16 weeks was terminated: it had lung hypoplasia with the prune-belly syndrome. The other two fetuses with obstruction were diagnosed at 25 and 34 weeks; the urinary tracts of both were drained for 5-14 days with reduction of distension. Both were born alive but that diagnosed at 25 weeks died of lung hypoplasia, the other survived, required nephrectomy and at the age of 3 is small but developing normally. Fetal urinary tract obstruction may prevent normal development of the lungs, be associated with other anomalies which cannot be diagnosed before delivery and retard infant development in survivors. Drainage of the dilated urinary tract does not harm the fetus or mother but has not been shown to improve neonatal survival or infant development.

Drainage↗
PubMed1983

Haemolytic-uraemic syndrome: an analysis of prognostic features.

Seventy-two children with the haemolytic-uraemic syndrome were seen between 1969 and 1980 at The Hospital for Sick Children and Guy's Hospital, London. They probably constitute the majority of such cases in south-east England during that period. Boys and girls were affected equally, the mean age at presentation was 3.5 years, and a peak incidence of the disorder in summer months was observed. In 52 (72%) there was a history of diarrhoea at onset. Fifty-seven (78%) were managed by dialysis. Fifty (70%) of the 72 children had a favourable outcome with complete recovery, 3 (4%) died in the acute phase of the illness, 8 (11%) had residual hypertension or chronic renal failure, and 11 (16%) never recovered renal function. The probability of complete recovery of renal function was analysed by logistic regression which indicated that younger age, presentation in the summer months, diarrhoea at onset and, in those patients who were dialysed, a short prodromal illness were associated with a good outcome. Further analysis of the interaction among these variables in the patient group as a whole indicated that diarrhoea favoured a good outcome among boys but not girls.

Acute Kidney Injury↗
PubMed1983

Goodpasture's syndrome: treatment with plasmapheresis, immunosuppression, and anticoagulation.

We report 3 children with Goodpasture's syndrome. In 2 children the diagnosis was delayed, treatment began late, and they did not recover renal function. In the third child early diagnosis and intensive treatment with plasmapheresis, immunosuppression, and anticoagulation resulted in an initial return of renal function after a prolonged period of anuria. In this child, however, although there was no evidence of disease activity, further deterioration of renal function subsequently occurred.

Anti-Glomerular Basement Membrane Disease↗