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Biomedical subjects

M J Clark

Publications and source records attributed to M J Clark.

At least 91 records · Page 5Linked to original sources

Tympanometric changes after total maxillary osteotomy.

With the frequency of orthognathic surgery increasing each year, more is being learned about this surgical art. Although techniques are improving, more acute and chronic complications are being reported after orthognathic surgery. In our institution, it has been noticed that approximately 25% to 30% of our patients experience unilateral or bilateral otalgia after total (Le Fort I) maxillary osteotomy. Recently, two patients with maxillary osteotomies. In both patients acute otitis media developed postoperatively and myringotomies for relief of symptoms were required. This paper reports changes observed in preoperative and postoperative tympanograms of patients who undergo total maxillary osteotomy and offers a possible explanation for these middle ear changes, which are accompanied by otalgia.

Acoustic Impedance Tests↗

Serum cholesterol of 6-year-olds in relation to environmental factors.

Serum cholesterol and triglyceride levels of 84 6-year-old children who have ben participants in a longitudinal diet and growth study were measured. These results were than related to past and present environmental factors. There appeared to be a slight inverse relationship between childhood activity levels and the 6-year-olds' serum cholesterol levels. Serum cholesterol levels at age 6 were significantly correlated with intake of dietary cholesterol at this age. A relationship between infant feeding and serum cholesterol levels at age 6 was not substantiated.

Activities of Daily Living↗

The keratinizing and calcifying odontogenic cyst (Gorlin cyst).

A 61-year-old white woman had a radiolucent lesion in the anterior portion of the mandible which was diagnosed as a keratinizing and calcifying odontogenic cyst. As it has a radiographic appearance similar to other pathologic processes, it should be considered in the differential diagnosis when a radiolucent-radiopaque lesion is encountered.

Diagnosis, Differential↗

Study of the Gregory blood group in an English family.

An example of anti-Gy-a found during routine antenatal testing is the first recorded example in Europe to be described. Five other Gy(a-) siblings were found in the patient's family from whom blood donations were obtained in the event of a needed transfusion. Although anti-Gy-a was detected in the infant's serum, there was no evidence of haemolytic disease of the newborn, presumably due to the fact that the Gy-a antigen is poorly developed at birth.

Blood Group Antigens↗

Value of the concomitant use of complement fixation and immunodiffusion tests in the diagnosis of coccidioidomycosis.

Complement fixation titers of 1:2 and 1:4 with coccidioidin are not always of diagnostic significance. The concurrent use of the complement fixation and immunodiffusion tests is an effective means for specific serologic diagnosis of coccidioidomycosis in patients with low levels of complement-fixing antibodies. In routine testing, it is recommended that only sera that are negative for complement-fixing antibodies at 1:8 but positive in the immunodiffusion test with coccidioidin be selected for titration at the 1:2 and 1:4 levels.

Antibodies, Fungal↗

Specific immunodiffusion test for blastomycosis.

A specific immunodiffusion test for blastomycosis has been developed. The test permitted the detection of approximately 80% of 113 proven cases of blastomycosis. Two diagnostically important precipitins designated A and B were frequently recognized in patients with blastomycosis. Routine use of reference sera containing the A and B precipitins in immunodiffusion tests would permit the specific diagnosis of blastomycosis without the need for parallel tests with coccidioidin and histoplasmin.

Antigens, Fungal↗

Comparison of macrocomplement and microcomplement fixation techniques used in fungus serology.

A comparative evaluation was performed on the micro- and macrocomplement fixation (CF) tests that are used as standard procedures in the serodiagnosis of blastomycosis, coccidioidomycosis, and histoplasmosis. Tests with 937 sera from suspected and culturally proven cases of these diseases against yeast-form antigens of Blastomyces dermatitidis and Histoplasma capsulatum and against the soluble antigens, coccidioidin and histoplasmin, revealed that the microtiters were within +/- 1 dilution of the macrotiters in 83 to 93% of the sera. Tests on randomly coded quality control sera revealed the microform of the CF test to be highly reproducible. Our studies indicate that the results obtained by the two tests have similar diagnostic and prognostic interpretations. Because of the sensitivity, reproducibility, economy, and ease of performance, the microtest is highly recommended for use in fungus serology.

Blastomyces↗