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Biomedical subjects

M J Chehval

Publications and source records attributed to M J Chehval.

At least 19 recordsLinked to original sources
PubMed2000

Effect of vasovasostomy on contralateral testicular damage associated with unilateral vasectomy in mature and immature Lewis rats.

OBJECTIVE: We sought to determine if laser-assisted vasovasostomy could reverse the contralateral histologic testicular changes associated with unilateral vasectomy. DESIGN: A prospective, randomized, blinded, controlled study. SETTING: Animal microsurgical laboratory, St. John's Mercy Medical Center, St. Louis, Missouri. PATIENT(S): Twenty mature and 20 immature male Lewis rats. INTERVENTION(S): Ten mature and 10 immature male Lewis rats underwent unilateral vasectomy. At 5 months, testicular biopsy and laser-assisted vasovasostomies were performed followed 2 months later by evaluation of vas patency and repeat testicular biopsy. Control animals consisted of 10 rats in each group, 5 that underwent sham operations and 5 that had halothane anesthesia alone. RESULT(S): In the immature and mature groups unilateral vasectomy resulted in marked contralateral testicular damage in 30% (3 of 10) and 50% (5 of 10), respectively. Vas patency determined 2 months after vasovasostomy was 80% (8 of 10) in the mature group and 89% (8 of 9) in the immature group. No animal that had contralateral testicular changes after vasectomy and a patent vas after vasovasostomy showed improvement in testicular histology. CONCLUSION(S): It appears that contralateral testicular damage associated with unilateral vasectomy is not improved 2 months after successful vasovasostomy in mature or immature Lewis rats.

Animals↗
PubMed1995

The effect of unilateral injury to the vas deferens on the contralateral testis in immature and adult rats.

The relationship between alterations in testicular histology and antisperm antibodies in immature and mature Lewis rats subjected to unilateral vasectomy was studied. Forty percent of immature rats and 90% of mature rats (p < 0.01) demonstrated significant alterations in both the obstructed (vasectomy) testis and the contralateral testis. There were significant changes in antisperm antibodies (ELISA) in the animals which demonstrated histologic changes.

Age Factors↗
PubMed1992

Removal of a multicystic half of a horseshoe kidney: significance of preoperative evaluation in identifying abnormal surgical anatomy.

A rare case of multicystic dysplasia in half of a horseshoe kidney is presented. Proper evaluation led to a modified surgical approach necessary for adequate exposure, division of the isthmus, and removal of the diseased component. Considerations applicable to the treatment of multicystic dysplasia and renal fusion are discussed. The surgical anatomy of horseshoe kidney is reviewed.

Female↗
PubMed1992

Deterioration of semen parameters over time in men with untreated varicocele: evidence of progressive testicular damage.

OBJECTIVE: To report observations of semen parameters in men with untreated varicocele over time. DESIGN: Semen parameters in 13 men with varicoceles were obtained at initial presentation, and re-evaluated at a 9 to 96-month interval because of persistent infertility. SETTING: Outpatient male fertility clinic. PATIENTS, PARTICIPANTS: Thirteen men who presented for fertility evaluation and who were found to have varicocele(s) and normal semen parameters. Re-evaluation was performed because of continued fertility problems. INTERVENTIONS: None. MAIN OUTCOME MEASURE: Semen parameters, especially sperm density, sperm mobility, and total sperm. RESULTS: Statistically significant deterioration was noted from normal to abnormal. CONCLUSION: In males with varicocele(s), normal semen parameters should not routinely be expected to remain normal over time.

Adult↗
PubMed1989

Colposcopy of condylomatous men.

The male partners of women diagnosed with human papilloma virus (HPV) or dysplasia were examined colposcopically. Anogenital infection was found in 82% of the men, and dysplasia in two of the partners of dysplastic women. Men may not be merely asymptomatic carriers of HPV.

Adult↗
PubMed1982

Human chorionic gonadotropin in the treatment of the infertile man.

We have treated 128 men with proved infertility with human chorionic gonadotropin. Excellent results were obtained in the patients who underwent varicocelectomy but who did not respond to the operation. Good results were obtained in the idiopathic oligospermic men, that is with sperm density less than 20 million. Indeterminate results were obtained in patients with sperm values more than 20 million. However, therapy was deemed inappropriate in those patients who either had elevation of follicle-stimulating hormone, an untreated varicocele or biopsy findings of hyalinization, or atrophy, which would preclude success of therapy.

Adult↗
PubMed1979

Chorionic gonadotropins in the treatment of the subfertile male.

Sixty-four men with idiopathic subfertility were given human chorionic gonadotropin, 50,000 units in 10 divided doses. Sixty-nine per cent of the men demonstrated significant improvement in semen quality in response to the medication, and thirty-six per cent achieved a pregnancy. Eight patients have achieved a second pregnancy without additional therapy.

Adult↗
PubMed1977

Adenocarcinoma of rete testis.

Adenocarcinoma of the rete testis is a very rare malignant neoplasm originating in the epithelium of the rete testis. Histologically, it appears as a papillary adenocarcinoma. The first case was reported in the literature in 1853 and since that time only 16 additional cases have been reported. This report represents the eighteenth case.

Adenocarcinoma↗
PubMed1977

A clinical evaluation of a new Silastic seminal fluid collection device.

A new Silastic seminal fluid collection device has been tested clinically and comparison studies have been made with both the polyethylene sheath and commercial latex condoms. In a series of 100 patients, the Silastic seminal fluid device has been found to be superior to the polyethylene sheath with regard to patient comfort and also has had greater reliability. In comparison with the latex device, the Silastic seminal fluid collection device is nearly as comfortable and has been found to be far more reliable.

Humans↗
PubMed1977

Meiotic indices in the oligospermic male.

Thirty-four oligospermic males were evaluated by determining the meiotic index in testicular biopsy specimens. Only 1 patient of 10 with a meiotic index of less than 15 achieved pregnancy, whereas 16 of 24 patients with a meiotic index of more than 15 had a successful outcome. Corresponding increases in the semenogram were also noted to be related to the meiotic index.

Biopsy↗