Determination of nitrogen in living patients.
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Biomedical subjects
Publications and source records attributed to M J Chamberlain.
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Serial measurements were made of total body calcium and sodium, using whole body neutron activation analysis, in six patients being treated for osteomalacia. All showed a rise in total body calcium ranging from 3 to 30%; this continued for up to 24 months after the start of treatment, though complete healing had apparently occurred after 6 months on the basis of histological examination of biopsy specimens of bone. As the total body calcium rose there was a fall in the non-exchangeable sodium pool in bone.
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Glucose tolerance tests performed on 12 patients within 15 hours of myocardial infarction and repeated two to four weeks later showed failure of insulin secretion, hyperglycaemia, glucose intolerance, and high free fatty acid levels. More pronounced changes were found in patients with cardiogenic shock. These findings suggest that the therapeutic use of potassium, glucose, and insulin should be re-evaluated.
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