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M J Bezou

Publications and source records attributed to M J Bezou.

36 records · Page 2Linked to original sources
PubMed1982

[Nitroblue tetrazolium test. Neonatal infections and antibiotic therapy].

The authors report the results of a prospective test of NBT carried out by an original method already described, and now used for seventy newborn babies. Eleven of them (group I) were tested by simultaneously taken samples from the cord and the heel in the labour ward. The levels obtained according to the position from which the samples were taken showen no significant difference. In 59 other infants (group 2) three successive tests were carried out in the first two weeks of life. These results were classified according to whether the children were: infected, perhaps infected and non-infected. The results confirm correlations between raised levels and infections. Giving antibiotic therapy does not alter significantly the levels in non-infected babies, nor the high positive scores in infected babies that were revealed in the four days after the start of treatment. Following this delay, levels of infected babies' blood did drop significantly, which was a probable indication of the efficacy of the antibiotic therapy.

Anti-Bacterial Agents↗
PubMed1981

Fibrin-fibrinogen degradation products in cerebrospinal fluid as an indicator of neonatal brain damage.

The occurrence of brain damage in 57 full term neonates was investigated. The infants were submitted to a prospective protocol involving clinical (neurological and electroencephalographical) and biological examinations, including the determination of the fibrin-fibrinogen degradation products in the blood and cerebrospinal fluid on D1, D3, D8 and D15. Psychomotor events were followed up for a year. Traumatic lumbar taps did not disturb the results significantly. Blood samples were not found to contain noticeable amounts of FDP. Conversely, the existence of FDP in CSF was not infrequent near to delivery and was shown to be closely related to brain damage as evaluated by the psychomotor events.

Apgar Score↗
PubMed1981

Qualitative cytology of cerebrospinal fluid as an indicator of neonatal brain damage and psychomotor outcome.

The authors report a double blind study on 57 full-term neonates prospectively subjected to clinical, electroencephalographical, cerebrospinal fluid and developmental examinations. Usual neonatal pleiocytosis depends on histiomonocytic cells which probably are a reflection of constant small brain damage during delivery. Infants suffering neurological sequelae at age one are recognizable as early as the 60th to 84th hours of life in view of persisting high histiomonocytic counts greater than 10 M. elements/l) and granulocytic peaks (greater than 2 M. elements/l) in clear samples. This method is then of interest, despite its invasive nature and limits (traumatic punctures, time-limits).

Apgar Score↗
PubMed1981

[Burkitt's type acute lymphoblastic leukemia. Cellular phenotype and chromosome abnormally (author's transl)].

A 13 year-old boy presented with Burkitt's type acute lymphoblastic leukemia (B-ALL). Studies of immune markers on his lymphoblasts suggest they have reached a fairly advanced level of differentiation with in the B-cell lineage. Presence of 1q+ and 8q- chromosomes suggest an unusual (1;8) translocation and is in agreement with current concepts concerning the frequent chromosome 8 changes in B-ALL.

Adolescent↗
PubMed1981

[Signification of fibrinogen degradation (FDP) product in CSF during the neonatal period (author's transl)].

Results of a prospective study on neonatal brain damage are reported. 57 full term newborns were subjected to clinical examination with a one year follow-up. Blood and CSF were sampled for FDP determinations on days J1, J3, J8 and when necessary, J15. Traumatic punctures do not alter results. FDP measurement were negative in the whole blood samples and most CSF ones. High FDP values in early samples are linked to brain damage and values above 4 micrograms/ml are significantly correlated to neurological sequelae.

Brain Damage, Chronic↗
PubMed1981

[Rapid screening for neonatal infection by employing new techniques for the use of the nitroblue tetrazolium test (NBT) (author's transl)].

A new method for carrying out the nitroblue tetrazolium test (NBT) has been used on micro-specimens taken from 116 newborn infants for the purpose of carrying out a prospective enquiry into neonatal infection. 44 children aged from 1 to 6 days were selected at random from a population that was said to be normal in the maternity unit and were the control group. 72 children of less than 48 hours of age were made to object of a prospective study of neonatal infection, an enquiry that allowed them to be divided into 3 groups: non-infected, infected and suspect. The study showed a very strong correlation between raised scores (higher than 100) and the presence of an infection, whereas scores in the controls and the non-infected infants were low. This test, which is hardly invasive and easy to introduce as a routine when carried out early is a good screening test for infection and can be best used on the newborn population in a maternity unit.

Bacterial Infections↗
PubMed1980

[The prognostic value of factor XIII in Schönlein-Henoch purpura in childhood (author's transl)].

In a prospective study of 19 cases of Schönlein-Henoch purpura, the factor XIII level was compared with 32 normal controls. The study demonstrates that factor XIII levels are of value both in making the diagnosis of Schönlein-Henoch purpura and predicting the outcome. If the factor XIII level is greater than 80% the diagnosis of Schönlein-Henoch purpura is unlikely and if factor XIII level is less than 60% of normal, the risk of complications is high.

Child↗
PubMedDate not supplied

Cerebrospinal fluid cytomorphology in neonates.

A prospective cytologic study of cerebrospinal fluids from 57 full-term neonates confirmed the previously reported cellular polymorphism. The cells were classified as (1) exogenous cells, (2) blood and bone-marrow cells, (3) histiomonocytes, (4) cell aggregates and (5) "free" cells. Histiomonocytes were a constant feature in these fluids and were the cause of neonatal pleiocytosis. Various degrees of activation could be recognized. The so-called inactive forms were closely related to brain damage. Identification of erythrophages and siderophages had diagnostic significance. The presence of fat in macrophages (lipophages) suggested a serious developmental disorder. The free cells were incompletely identified, as were the cell aggregates, which probably originate in the meningeal lining. Both require further study.

Bone Marrow Cells↗