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Biomedical subjects

M Izuo

Publications and source records attributed to M Izuo.

At least 55 records · Page 3Linked to original sources
PubMed1989

Mass screening for breast cancer: comparison of the clinical stages and prognosis of breast cancer detected by mass screening and in out-patient clinics.

To establish the criteria for assessing the life-prolonging effect of mass screening for breast cancer, clinical stage and prognosis of breast cancer detected by mass screening in 11 regions of Japan were compared with those for matched patients in out-patient clinics. A total of 728 patients detected by mass screening and 1,450 found in the out-patient clinics were reviewed. The stage of the disease was Tis or I in 40.9% of the patients detected by mass screening, and 28.7% of those found in the out-patient clinics. In contrast, stage III was found in 9.3% and 14.6%, respectively, indicating that early stages were significantly more common in the patients detected by mass screening. The overall survival curve for the patients detected by mass screening was compared with that for those found in the out-patient clinics. The 5-year survival rate was significantly higher in the patients detected by mass screening (91.7% vs. 85.6%; P less than 0.01), while the 10-year survival rate was slightly higher in the same group of patients, but the difference from the other group was not significant (80.5% vs. 78.1%). Women who had conducted breast self-examination (BSE) showed a higher survival rate than those who had not conducted BSE.

Breast Neoplasms↗
PubMed1989

Effects of trilostane on 7,12-dimethylbenz[a]anthracene-induced rat mammary cancers and body weight of rats in relation to estrogen receptors.

Effects of trilostane (TLS) on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary cancers and body weight of rats were examined in relation to estrogen receptors (ER) in 103 female Sprague-Dawley rats with DMBA-induced cancers. The inhibitory effects of the treated groups on the growth of DMBA-induced rat mammary cancers were significantly stronger than those of the control group at many points during the treatment, demonstrating a more remarkable inhibitory effect in the high-dose groups of 300 and 500 mg/kg. In the high-dose groups, the inhibitory effects of TLS tended to be slightly stronger in the ER-negative groups than in the ER-positive groups. These results suggest that the mechanisms of action of TLS are not influenced by the presence or absence of ER, but are due to complicated hormonal changes induced by the inhibition of steroid biosynthesis.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1989

[Colony stimulating factor producing carcinoma of the pancreas--a case report].

Reported is the case of a 71-year-old male patient with a pancreatic carcinoma that showed marked leucocytosis of up to 71300/mm3. Tests revealed that the patient's granulocyte-colony stimulating factor (G-CSF) in serum was 0.65 ng/ml and 0.74 ng/ml in pleural effusion, these values almost triple the values of a normal control (0.20 in serum, 0.25 ng/ml in pleural effusion). These findings have indicated that the tumor itself was responsible for producing the inflated values of the granulocyte-colony stimulating factor. This case of a G-CSF-producing pancreatic carcinoma is discussed, along with a review of the pertinent literature.

Adenocarcinoma↗
PubMed1989

Sequential hormone therapy with medroxyprogesterone acetate for 7, 12-dimethylbenz [alpha] anthracene-induced rat mammary tumors.

Two types of sequential hormone therapy with medroxyprogesterone acetate (MPA) were examined in female 93 Sprague--Dawley (SD) rats with 7,12-dimethylbenz [alpha] anthracene (DMBA)-induced mammary tumors. Estradiol (E2) priming induced progesterone receptors (PgR) in most cases and, after induction of PgR, MPA often showed an augmented antitumor effect. For this reason, E2 priming + MPA had a more marked antitumor effect on DMBA tumors than MPA alone. Tamoxifen (TAM) (0.1 mg/kg) priming induced PgR more frequently than TAM (0.4 mg/kg) priming. Furthermore, treatment with TAM priming (0.1 mg/kg) + MPA showed a more marked antitumor effect than with TAM priming (0.4 mg/kg) + MPA or MPA alone. In the above two priming therapies with MPA, the latter is more practical for the clinical treatment of breast cancer than the former because the mechanism of action of E2 is usually thought to show tumorigenic activity on breast cancer, while the mechanism of action of TAM is thought to show an antitumor effect. It is suggested that the sequence of administration of MPA after TAM priming may be favorable for the treatment of breast cancer.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1989

[A case of duodenal carcinoid associated with early gastric carcinoma].

This case involves a 51-year-old female. In 1983, a gastroscopic examination disclosed a submucosal tumor in the duodenum. In 1986, during follow-up observation, on her visit to hospital an early gastric carcinoma at the antrum was found. Thus, a distal gastrectomy, which entailed the complete removal of the Group 2 lymph nodes and the hepatoduodenal, intra-mesenteric lymph nodes, and Billroth I reconstructive surgery were both performed. A histopathological examination revealed that the antral lesion was a carcinoma, sig. m. ly0. v0. n(-), and that a lesion at the duodenal bulb was carcinoid, with cell that were positive to Grimelius staining and to somatostatin serotonin by an immunological staining. A metastases to the lymph nodes but only along the upper trunk of the common hepatic artery, also was found.

Adenocarcinoma↗
PubMed1989

[A case of quartet cancer--a carcinoma of the breast followed by three synchronous cancers (kidney, thyroid and colon)].

A case of a surgically treated primary quartet cancer is reported, along with a review of the Japanese literature. A 68-year-old woman, curatively operated for a right breast cancer 6 years previously, was then diagnosed as having a left renal cell carcinoma, a thyroid cancer, and a sigmoid colon cancer as a result of a subsequent screening examination within one year. These synchronous, triple cancers were resected in a curative operation for each. Histopathologically, each neoplasm was proven to be a primary cancer lesion, and two different types (papillary and trabecular) were found in the thyroid gland.

Adenocarcinoma↗
PubMed1989

[Recent trends in breast cancer surgery in Japan].

In the past ten years, extended or conventional radical mastectomies have decreased, being replaced by modified radical mastectomies (muscle-preserving mastectomies) such as Auchinoloss' operation and Patey's operation. Furthermore, limited surgeries for early cases such as partial mastectomy, lumpectomy etc. also have increased in the recent three years. The indications for these operations, the surgical techniques, postoperative functional and cosmetic problems were presented. And future problems as to partial mastectomy were also discussed. In contrast, aggressive surgery such as extensive resection of the chest wall for locally advanced breast cancer is useful as one of the therapeutic measures in the recent multidisciplinary treatments for breast cancer, in order to prolong the patient's survival and improve the quality of life. The techniques including the reconstruction using musculocutaneous flaps were also presented.

Breast↗
PubMed1989

[A case of primary gastric choriocarcinoma].

A 66-year-old man with a primary gastric choriocarcinoma is presented. The pre-operative diagnosis of the gastric barium examination and an endoscopy was an unusual gastric carcinoma in the antrum. At laparotomy, an abscess in the lesser sac that had developed by a tumoral penetrance was found. Thus a total gastrectomy and a lymphadenectomy with a reconstruction was performed. The resected specimen was found to be a Borrmann 1 type tumor, and a histological examination showed it to be a choriocarcinoma with a syncytiotrophoblast, that was immunostained by human chorionic gonadotropin (HCG). The physical findings however, disclosed no tumor in the testis. The serum HCG was found to be 1,380 IU/l on the 7th postoperative day, then a pulmonary metastases appeared and progressed, and the patient died on the 22nd postoperative day.

Aged↗
PubMed1989

Evaluation of dot-immunobinding assay for carcinoembryonic antigen determination in nipple discharge as an adjunct in the diagnosis of early breast cancer. Research Group for Carcinoembryonic Antigen in Nipple Discharge.

We have previously reported carcinoembryonic antigen (CEA) measurement in nipple discharge to be a useful adjunct in the diagnosis of non-palpable breast cancer. As an extension, a dot-immunobinding assay was developed to screen a large number of patients with nipple discharge for non-palpable breast cancer. The principle is as follows. CEA bound to a solid phase monoclonal anti-CEA antibody is detected by a second monoclonal anti-CEA antibody conjugated with horseradish peroxidase. The use of tetramethylbenzidine as a chromogen results in a stable color reaction that can be semiquantitively analyzed by the naked eye. The CEA levels determined by this dot assay correlated well with CEA levels determined using the former Elmotec assay. To determine whether or not the method could also be feasible in the detection of non-palpable breast cancer, a collaborative study from 12 Japanese institutes was organized. The CEA levels in nipple discharges from 155 patients were assayed. Thirteen of 30 patients with palpable breast cancer and 22 of 30 patients with non-palpable breast cancer exhibited CEA values higher than 400 ng/ml, a cut-off value determined using 89 benign controls. The specificity (91%) and sensitivity (73%) of this test were higher than those of mammography or cytology. The incidence of elevated CEA levels in nipple discharge correlated significantly with the incidence of intratumoral antigen expression. Thus, the system could prove useful in screening for early breast cancer.

Body Fluids↗
PubMed1989

[Surgical procedure and adjuvant therapy in breast cancer].

Modified radical mastectomy (Auchincloss or Patey) have been generally performed for early breast cancer. And this method has shown better prognosis compared with standard (Halsted) or extended radical mastectomy. Also minor conservative surgery (breast or nipple preserving procedure) with or without radiation has been recently tried in small groups of Japan. Postoperative adjuvant chemotherapy (FEMP) has been used in patients proved histologically vascular invasion of cancer cells in our department. Postoperative radiotherapy were undertaken in patients with 4 or more positive axillary nodes or positive parasternal and supraclavicular nodes. Extended radical mastectomy is considered as a favorable method to improve the disease-free survival of the patients with advanced breast cancer, including the combination of chemotherapy, endocrine therapy and radiotherapy. It is important that surgical procedures for breast cancer should be selected and conducted along with a multimodal treatment according to stage for a case by case under the concept of "systemic disease".

Breast Neoplasms↗
PubMed1988

[Characterization of thyroglobulin and thyroid peroxidase activity in patients with functioning thyroid benign tumors].

The content and chemical and immunological properties of thyroglobulin (Tg) and the activity of thyroid peroxidase (TPO) were studied in nodular and extranodular (periphery) thyroid tissue from patients with functioning thyroid tumors (hot nodules). From the present observations, the tumor extracts contained fairly large amounts of Tg, similar to that in the periphery tissue, while the content of Tg was markedly decreased in non-functioning thyroid tumors (cold nodules). The iodine content of Tg was significantly higher in nodular tissue compared with periphery tissue. These observations were in contrast to the results seen in the cold nodules in which hormone synthesis was defective. On the nature of carbohydrate moiety as compared with normal tissue, oligosaccharides of Tg from the periphery tissues changed in a manner similar to that of tumor oligosaccharides. That is, high-mannose type oligosaccharides were markedly decreased whereas multiantennary and unidentified oligosaccharides were increased. These observations were similar to those of non-functioning tumors. The content of sialic acid decreased markedly both in the tumor and periphery tissues. Immunologically, Tg preparations of the tumor and periphery tissue did not show the same affinity to the antibodies, depending on the content of iodine. Therefore, it seems that the contribution of the iodine content and iodo-amino acid has little or no significance in the heterogeneous nature of Tg-immunogenecity. Benign tumors and the periphery tissue were subjected to assay for thyroid peroxidase activity by the method employing guaiacol as the second substrate. The specific activities of the tumors were generally higher than those of periphery tissues, both in functioning and non-functioning benign tumors. In non-functioning carcinoma, on the other hand, TPO activities were lower in tumor portions than in periphery portions. This indicates that non-functioning thyroid carcinomas have a different characteristic.

Adenoma↗
PubMed1988

Chest wall resection and reconstruction for locoregionally advanced or recurrent breast cancer.

Ten patients, including 7 with local recurrent breast cancer, 2 with primary advanced cancer and 1 with radionecrosis, underwent chest wall resection and immediate reconstruction, using large pedicled skin flaps or musculocutaneous flaps. A rectus abdominis musculocutaneous flap was used in 4 cases and a latissimus dorsi musculocutaneous flap was used in 1 case. The postoperative course of all the patients was uneventful and there was no incidence of flail chest or respiratory failure. The postoperative performance status and also the quality of life were improved in 9 of the 10 patients. Eight of the 10 patients are presently alive with or without disease, the longest survival time thus far being 8 years.

Adult↗
PubMed1988

Two cases of lipid-secreting carcinoma of the breast: case reports with an electron microscopic study.

Two very rare cases of lipid-secreting carcinoma of the breast are reported, together with a review of the literature. Both patients were Japanese women aged 70 and 81 years, respectively. In each, a mass had been found in the breast, and radical mastectomies were performed based on a diagnosis of breast cancer at an early clinical stage. Both resected tumors were found to be solid and localized. In them, both estrogen and progesterone receptors were negative. Microscopically, hematoxylin-eosin staining showed the tumor cells to have foamy and vacuolated eosinophilic cytoplasm. Lipid staining showed the vesicles in the cytoplasm of the tumor cells to be colored a flaming red and consequently recognized as lipid droplets. An electron-microscopic study showed that the tumor cells contained various sizes of lipid droplets in the cytoplasm with no degenerative changes, and suggested that these lipid droplets were produced and stored in the tumor cells. It would appear, from the literature that lipid-secreting carcinomas have aggressive clinical courses, but neither vascular invasion nor lymph node metastasis was seen in either of our two cases.

Aged↗
PubMed1988

[A clinicopathological study of multiple thyroid carcinomas].

Thyroid cancers associated with multiple cancerous lesions that were detected by clinical and/or histological examination, namely, multiple thyroid carcinomas have been studied clinicopathologically. Of 443 cases of primary thyroid cancers, 111 (25%) had multiple cancerous lesions. Histologically, most multiple cancers consisted of papillary carcinomas. In 66% of the cases, the size of the second cancer was 1.0 cm or less. Fifty-three percent of multiple cancers were located in both the right and left thyroid lobes. Therefore, it is important to examine the contralateral lobe at operation to be certain that there are no other nodular lesions. Since lymph node metastasis was positive in 83% of the cases, it is necessary to perform bilateral neck dissection in multiple cancer cases of not only the bilateral but also of the unilateral type.

Carcinoma, Papillary↗
PubMed1988

Evaluation of mass screening for thyroid cancer.

Mass screening for detecting both thyroid and breast cancer in adult women was carried out in Gunma Prefecture, Japan, between 1980 and 1986. The total number of subjects during the seven years was 152,651. The first screening was by inspection and palpation using experienced surgeons. Thyroid abnormalities were found in 5,902 subjects (3.9%) and 3,804 (2.5%) were required to attend a second examination. Thyroid carcinoma was detected in a total of 216 subjects, a detection rate of 0.14%. The detection rate for thyroid cancer was twice as high at the initial screening (0.19%) than that at subsequent periodic screenings (0.09%). Histological classifications of the detected thyroid cancers were: papillary carcinoma, 189 cases (87.5%); follicular carcinoma, 26 (12%); medullary carcinoma, 1 (0.5%). Eighty-seven percent of the thyroid cancers were asymptomatic at the time of screening. The tumor size were 2 cm or less in 126 patients (58.3%). Thyroid cancer detected by mass screening was revealed at an earlier stage and showed a significantly better survival rate compared to that of our usual outpatients. As differentiated carcinoma has been found at a higher incidence by mass screening, the program is useful for the early detection and treatment of thyroid cancer.

Adult↗