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Biomedical subjects

M Izembart

Publications and source records attributed to M Izembart.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Improvement of the prognosis of Basedow's disease by using high doses of carbimazole].

The influence of synthetic antithyroid drug dosage on the course of Graves' disease was evaluated by comparing two groups of matched patients treated with carbimazole. Thirty-seven patients received a rapidly degressive treatment (60 mg/day initially rapidly reduced without replacement thyroid hormone therapy), and 36 patients received a prolonged treatment in high doses (60 mg daily for 6 months with progressive reduction of dosage over 5 months and replacement therapy). There was a highly significant difference in the actuarial curves of patients without relapse during 36 months: 82 per cent in patients with high doses, as against 38 per cent in patients with rapidly degressive treatment (log rank: chi 2 = 7.67, P less than 0.01). The anti-TSH receptor antibody titers decreased more rapidly in patients under prolonged treatment with high doses than in those with the rapidly degressive treatment. It is concluded that carbimazole in high doses is more immunosuppressive than in rapidly degressive doses and that it improves the prognosis of Graves' disease.

Adult↗
PubMed1988

[Thyroid function and trisomy 21. TSH increase and rT3 deficiency].

An excess of thyrotropin (TSH) with normal levels of tetraiodothyronine (T4) and of 3,5,3'-triiodothyronine (T3) was confirmed in the serum of 78 trisomy 21 children. A severe deficiency of 3,3',5'-triiodo-thyronine (rT3 or reverse T3) was observed and the decrease of the rT3/TSH ratio was highly significant. These new facts suggest that the rT3 deficiency plays a peculiar role in trisomy 21 (maybe through the regulation of one or few steps of monocarbons' metabolism). A systematic control of thyroid function (including the patient's rT3 level) is mandatory for the follow-up of every trisomy 21 patient.

Adolescent↗
PubMed1988

Thyroglobulin secretion by cultured human thyroid cells from cold nodules.

An elevated serum thyroglobulin level has been demonstrated in patients with cold nodules, without determination of the exact cause. In this preliminary study, we examined thyroglobulin production in vitro by cells from cold nodules and compared it to that of normal cells taken from the contralateral lobe of the same patient. Cells were cultured in monolayer and in collagen gel. Differences were observed between normal and pathological cells depending upon the culture model. We have attempted to interpret these differences which could result from anomalies in the pathological cells at the level of the apical membrane.

Cells, Cultured↗
PubMed1987

[New method of estimating iodine overload in the urine from a simple urination].

Iodine research holds an increasing place in thyroid pathology, either to cover a radioisotopic investigation with paradoxal results or to find an iatrogenic cause to an unexplained hypo- or hyperthyroidism in new born children as well as in adults. To determine iodine overloads we may need a urinary iodine estimation, in addition to blood iodine determination (quickly eliminated products) or instead of it (difficult blood taking: new born children, etc.). Classically, the 24 hours urinary iodine estimation (total urinary iodine) covers this need but, in practice, as we generally deal with ambulatory patients, the risks linked to the obtention of a perfect 24 hours urine collecting make us abandon it. This article presents an original and simple way of getting round this difficulty: it demonstrates that an excellent iodine overload estimation can be obtained by measuring simultaneously from a simple miction: on one hand iodine concentration, on the other hand the urinary creatinine.

Adolescent↗
PubMed1987

[Thyroid biological evaluation: critical study].

Laboratory tests to assess thyroid gland function have changed considerably over the past few years, with the development of techniques allowing for the direct routine determination of unbound thyroid hormones (tri and tetra-iodothyronine), the "ultra-sensitive" assay of serum concentrations of TSH (thyroid-stimulating hormone) and finally, the radioimmunological assay of anti TSH-receptor antibodies. In our study, which excluded patients having an excess of iodine or who had serious disease of an organ other than the thyroid, we assessed the impact of these parameters respectively on various disease categories. An innovation has been made in that anti TSH-receptor antibody assay is now possible in everyday practice while up to the present this was only possible in the hospital setting and with a limited number of cases: this titer is important as a classification parameter in diagnosing Grave's disease and has prognostic importance to monitor treatment of patients suffering from this disorder. The "ultrasensitive" version of measuring thyrotropic hormone requires a new strategy: TSH assessment becomes the first-line diagnosis test to evaluate thyroid function because it differentiates from control subjects, as well as patients with hyper ou hypothyroidism who are not receiving therapy. In other cases, dosing of the free hormones T3 and T4 remains a vital supplementary test.

Graves Disease↗
PubMed1986

[Serum thyroglobulin is elevated in patients with heterogeneous goiter during radioiodide scintigraphy, but normal in those with homogeneous goiter].

Serum thyroglobulin (Tg) levels were determined in 98 biologically euthyroid patients with a diffuse or nodular goiter, and compared to values observed in 33 control subjects. Based on the results of clinical examination and thyroid scanning with radioiodine, patients were divided into 3 groups: group 1 with homogeneous diffuse goiters, group 2 with heterogeneous diffuse goiters without palpable nodules, and group 3 with solitary hypofunctioning nodules. The control group had a mean Tg of 37 +/- 15 micrograms/l. Group 1 (n = 32) had a mean Tg of 46 +/- 28 micrograms/l; six (19%) had an elevated Tg level (level greater than 74 micrograms/l). Group 2 (n = 30) had a mean Tg of 133 +/- 134 micrograms/l; fourteen (47%) had an elevated Tg level. Group 3 (n = 36) had a mean Tg of 188 +/- 191 micrograms/l; twenty (56%) had an elevated Tg level. The comparison of Tg between patient groups, and between patients groups and the control group, showed a significantly higher value in the groups of hypofunctioning nodules and heterogeneous diffuse goiters. It is concluded that the elevated serum Tg level in patients with a diffuse or nodular simple goiter is commonly associated with heterogeneity of the thyroid scan.

Adolescent↗
PubMed1986

[Prognostic value of anti-TSH receptor antibodies in Basedow's disease treated with carbimazole].

In order to precise their prognostic value, the anti-TSH receptor antibodies (TRAK) have been measured in 70 cases of Graves' disease treated with carbimazole. Results (expressed in percentage of inhibition of labeled TSH binding) were grouped into 7 mean values: before treatment, from 15 days to 3 months, from 3 to 12 months, 2nd, 3rd, 4th and 5th years. For all cases together, a progressive decrease was observed: 40, 37, 29, 19, 14, 10, 7 p. 100. In 16 cases with good outcome, the mean values are significantly lower than those of 29 cases with bad outcome, respectively: 33 vs 46, 29 vs 43, 17 vs 30, 12 vs 27, 11 vs 22, 3 vs 15, 1 vs 11 p. 100. The TRAK titers at whatever t time are correlated to the clinical state at t + 2 years: about 30 p. 100 relapses if the TRAK titer is less than 10 p. 100; about 80 p. 100 relapses if it is 80 p. 100. So, the anti-TSH receptor antibodies have their place among the prognostic parameters of Graves' disease treated with carbimazole.

Antibodies↗
PubMed1985

Serum thyroglobulin levels in hypofunctioning nodules before and after surgery.

Serum thyroglobulin (Tg) level was determined in 34 biologically euthyroid patients having benign hypofunctioning nodule, before and after surgery. Based on the results of thyroid scanning with radioiodine, 2 groups of patients were considered. Group 1 (n = 18) had solitary hypofunctioning nodule with an otherwise normal thyroid gland and group 2 (n = 16) had hypofunctioning nodule inside an enlarged and/or heterogeneous thyroid. Results were compared to a group of 30 control subjects. Mean Tg level was significantly elevated in both groups 1 and 2 before surgery. No significant difference was found between group 1 and group 2. After surgical removal of the hypofunctioning nodule (follicular adenoma), mean Tg level was normalized in group 1 and decreased but still remained elevated in group 2. It is concluded that the observed elevated serum Tg level is due to the presence of hypofunctioning nodule and/or heterogeneous thyroid tissue. Thus, Tg determination may be useful in the follow-up of operated hypofunctioning nodules in order to detect abnormality in the remaining thyroid tissue.

Adenoma↗
PubMed1984

[Limiting values of serum thyroglobulin observed in athyrosis].

Investigations in 6 cases of congenital or acquired athyreosis show that serum thyroglobulin determined in these cases by radioimmunology is not due to a determination artifact or to another protein, but that, with regard to immunoreactivity, molar mass and isoelectric point, it displays all the features of the standard thyroglobulin of thyroid origin and of the serum thyroglobulin of normal subjects. The authors conclude that small quantities of thyroglobulin are present in the serum of such patients, even where all the other criteria of athyrosis appear to be present.

Congenital Hypothyroidism↗