Biomedical subjects
Publications and source records attributed to M Izawa.
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New antitumor antibiotics, macbecins I and II, were isolated from the culture broth of Nocardia sp. No. C-14919. Macbecins I and II belong to the ansamycin group and have a benzoquinone and hydroquinone nucleus, respectively. Both showed antitumor activity against murine leukemia P 388 in vivo.
A case of aortitis syndrome (pulseless disease) associated with basilar aneurysm is reported. This patient was 52-year-old woman suffering from pulseless disease for past fifteen years. She was admitted to our hospital with severe headache, nausea and vomiting. Four vessel angiograms revealed an aneurysm of the basilar artery and occlusion of the right vertebral artery. The internal carotid artery in the left side and the subclavian artery in the right side were not demonstrated even by the serial aortography. As regard to the pathogenesis of cerebral aneurysms associated with aortitis syndrome, questions are in discuss whether the aneurysm is of congenital nature or the result of acquired arteriosclerosis due to aortitis syndrome. In addition, the rupture mechanism of basilar aneurysm associated with aortitis syndrome is discussed.
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Recent reports on the binding of glucocorticoid-receptor complexes to rat liver nuclei suggested the presence of components which inhibited the binding. The inhibitory component(s) of the receptor translocation was observed not only in the cytosol of the liver but also in cytosols of the kidney, the spleen and the thymus. The cytoplasmic levels of the inhibitor in these tissues were not modified by the administration of Dexamthasone (DEX). The liver inhibitor was macromolecular and clearly separated from the DEX-receptor complex on DEAE-cellulose chromatography. The mechanism of the inhibition seemed to be an interaction between the inhibitor and the steroid-receptor complex. In addition, the inhibition seemed to be less specific for the bindings of different steroid-receptor complexes to nuclei. The bindings of hepatic 3H-DEX-receptor complex by nuclei derived from livers of adrenalectomized and DEX-treated rats, in the presence or absence of the translocation inhibitor, were similar.
The pharmacological effects of fosfomycin sodium, a new antibiotic agent, were studied on central nervous system, neuromuscular junction, isolated smooth muscles, blood coagulation, red blood cell resistance, body temperature, permeability of skin vessels and IgG and IgE antibody formation in laboratory animals. Fosfomycin sodium inhibited activities on the isolated smooth muscles, elevated body temperature, and increased permeability of skin vessels. Any of these actions, however, was noticeable only when it was administered in higher doses. Except for these above effects, fosfomycin sodium did not show any actions. Consequently, it can be concluded that fosfomycin sodium has no specific pharmacological actions.
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Cytoplasmic 3H-5alpha-dihydrotestosterone-receptor complex of the rat ventral prostate was efficiently taken up by nuclei isolated from the liver, the ventral prostate and the spleen. The amount of the complex bound to liver nuclei was approximately 3 times that to prostate nuclei, and a relatively small amount of the complex was taken up by spleen nuclei under the incubation conditions: 0.16 nM complex (2.0 mg as protein) was used. Binding of the complex to liver nuclei was low-affinity and non-saturable, while in nuclei from the ventral prostate and the spleen, high-affinity and saturable binding was observed. Kd of nuclear binding in the latter two tissues was roughly of the order of 10(-10) M. Castration caused a reduction in the binding of the complex to prostate nuclei and replacement therapy with testosterone propionate completely blocked the effect of castration on the nuclear binding. The affinity of high-affinity binding was not changed significantly after castration. No significant effects of castration and testosterone treatment were observed in the binding of nuclei from the other two tissues examined. The physiological significance of the nuclear binding of hormone-receptor complexes in the action of steroid hormones is discussed.
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A case of skull tumor simulating sinus pericranii is presented. The tumor was situated in the occiput near the midline and it was thought to satisfy the diagnostic criteria of sinus pericranii. At operation the tumor proved to be eosinophilic granuloma with intratumorous hemorrhage associated with epidural hematoma.
Many cases of dural arteriovenous malformation have been reported recently. However, the surgical treatment for these diseases has not been established yet. We propose a new method of treatment on this peculiar vascular diseases, that is one of the artificial embolizations; A catheter is inserted into feeding artery, from which liquid silicon rubber, Phycon, is injected. The rubber is hardened in the vascular net-work. It can not pass into drainer because of its viscosity. Therefore the malformation never develope again. We tried this new method on 46-year-old woman, who suffered from subarachnoidal bleeding, tinnitus and headache. The left common carotid and vertebral angiography revealed dural arteriovenous malformation in posterior fossa (Fig. 1); the feeding arteries of which were middle meningeal arteries, occipital artery, and tentorial artery, etc; the drainers were transverse and sigmoid sinuses. We treated for this case with above-mentioned method; The liquid plastic of 1 - 2 ml injected into each of the main feeding arteries, namely two middle meningeal arteries and occipital artery. Postoperative angiograms revealed this technic was convenient and sufficient for the treatment of dural arteriovenous malformations (Fig. 7).
The successful treatment of a dural arteriovenous malformation in the region of the transverse-sigmoid sinus by artificial embolization with liquid silicone is reported. The clinical and radioanatomical characteristics of the lesion are described. The technical feasibility of embolization is discussed and compared with other surgical treatments.
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Analysis of proteins in nucleoli and chromatin of mouse ascites tumor cells labeled with [32P]orthophosphate by SDS-polyacrylamide gel electrophoresis showed that a highly radioactive protein was localized in the nucleoli. This protein was purified and the final preparation appeared as a single component on hydroxylapatite column chromatography with or without SDS. This protein was found to be a nucleolus-specific phosphoprotein with a molecular weight of 120 000. The phosphate moiety in this protein turned over very rapidly whereas the protein itself was stable. When the nucleoli were disrupted by EDTA treatment, this unique protein was found as a major protein constituent of the ultracentrifugal supernatant.
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