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Biomedical subjects

M Iturralde

Publications and source records attributed to M Iturralde.

At least 37 records · Page 2Linked to original sources
PubMed1985

Assessment of ventricular function by radionuclide angiography in patients receiving 4'-epidoxorubicin and mitoxantrone.

Serial assessment of ventricular function by means of radionuclide angiography was performed in 50 patients with malignant neoplasms who received either 4'-epidoxorubicin or mitoxantrone for longer than 3 months. In 9 of 30 patients given 4'-epidoxorubicin, a decrease of greater than or equal to 10% in the left ventricular ejection fraction (LVEF) was documented at doses of 143-1200 mg/m2. Two patients developed clinical signs of cardiotoxicity at a dose of greater than 1000 mg/m2. In 6 of 20 patients given mitoxantrone a decrease of greater than or equal to 10% in the LVEF occurred at doses of 26-98 mg/m2.

Adolescent↗
PubMed1984

High stability hybrids producing monoclonal antibodies against human C-reactive protein.

This report shows how high stability hybrids producing monoclonal antibodies against human C-reactive protein were raised and selected. Monoclonal antibodies can be produced in large enough quantities through this method, to allow for the design and use of quantitative C-reactive protein determination on a clinical scale. This novel strategy consisted of the following: growing the hybrids and freezing them before cloning in order to assure stability and selecting the hybrids from those producing high titres in mouse ascite induction. Two monoclonal antibodies of high stability and great potential for large scale production have been developed in this manner. Production on a large scale of these monoclonal antibodies against human C-reactive protein can be useful both in clinical quantification and in physiological studies concerning its still unknown in vivo function.

Animals↗
PubMed1983

Amsacrine cardiotoxicity: assessment of ventricular function by radionuclide angiography.

Serial assessment of ventricular function by means of a nuclear medicine technique was performed in six patients with malignant disease receiving chemotherapy with amsacrine. Two patients who received treatment long enough so that greater than 580 mg/m2 of the drug was administered showed a significant decrease in left ventricular ejection fraction. Four patients who received total doses of 325-510 mg/m2 of amsacrine did not experience significant change in their cardiac function.

Aged↗
PubMed1981

[Radionuclide exercise gated studies in female patients with positive exercise electrocardiogram].

Radionuclide left ventricular ejection fraction (LVEF) has been determined in a group of 14 female patients at rest and during graded supine bicycle exercise. One group consisted of 9 patients complaining of chest pain and demonstrating positive exercise electrocardiography (EECG), but with normal contrast angiographic results. The second group of 5 patients had a normal response to EECG and was used as a control group. LVEF increased markedly in both groups during exercise. This study confirms the known fact of high false-positive EECG in female patients and that exercise radionuclide LVEF response can be used as a final screening test for cardiac catheterization in female patients demonstrating positive EECG.

Adult↗
PubMed1981

Hysterosalpingo-radionuclide scintigraphy (HERS).

A radionuclide procedure, hysterosalpingo-radionuclide scintigraphy (HERS), was designed to evaluate the migration of a particulate radioactive tracer from the vagina to the peritoneal cavity and ovaries as well as to image and functionally outline the patency of the pathways between these two extremes of the female reproductive system. Technetium-99m human albumin microspheres (99mTc-HAM) were deposited in the posterior fornices of patients who were divided into two specific groups. Group I consisted of patients who were to undergo different elective gynecologic operations, in which besides obtaining sequential images, radioactivity levels were measured in the removed organs and tissues. Group II consisted of patients referred by the Infertility Clinic for evaluation of their reproductive system pathways patency. In this latter group, HERS was compared with contrast hysterosalpingography (HSG) and peritoneoscopy (PCP). The results obtained from measurements of radioactivity levels on the removed surgical specimens and comparison with other conventional gynecologic diagnostic procedures provide accurate evidence of the migration of 99mTc-HAM from the vagina, through the uterus and tubes, to the peritoneal cavity and ovaries, and show that HERS is a simple noninvasive method for functionally imaging and assessing the patency of the female reproductive system pathways.

Female↗
PubMed1979

Global and regional assessment of cardiac performance by ECG-gated radionuclide blood pool imaging.

A non-invasive method for evaluation of regional and global ventricular function by ECG-gated radionuclide blood pool imaging was developed. Cinematic image display is a sensitive method for evaluating wall motion to detect regional ventricular abnormalities and chamber size. A value of r = 0,86 and 0,85 was found for both fixed and variable area radionuclide methods when these ejection fraction values were correlated with cardio-angiographic ejection fraction values in normal subjects and in patients with myocardial infarction. The fixed area method underestimated the ejection fraction in patients with mitra valve stenosis, but this problem can be overcome with the variable area method. The technique developed cannot be used in patients with severe arrhythmias (r = 0,49 and 0,44).

Blood Circulation↗
PubMed1979

Migration of a particulate radioactive tracer from the vagina to the peritoneal cavity and ovaries.

In this report we describe a radionuclide procedure designed to evaluate the migration of a particulate radioactive tracer from the vagina to the peritoneal cavity and ovaries, as well as the determination of the patency of the pathways between these two extremes of the female reproductive system. 99mTc-labelled human albumin microspheres (99mTc-HAM) were deposited in the posterior fornices of 24 patients a day before they were to undergo different gynaecological operations. During this period sequential images were obtained and after the operation radioactivity levels in the removed organs and tissues were counted with a scintillation detector. In 14 out of 21 cases, the ovaries and fallopian tubes were counted separately from the uterus. Nine were positive (radioactivity levels were sufficiently high in the tubes and ovaries) and 5 were negative (no substantial radioactivity levels could be detected in either the tubes or the ovaries). The 5 negative results all occurred in patients with proved tubal damage as a result of previous infection. All the results were either true positive or true negative, providing evidence of migration, or obstruction, of 99mTc-HAM from the vagina through the uterus and tubes to the peritoneal cavity and ovaries.

Adult↗
PubMed1979

A krypton-81m generator for organ ventilation and perfusion investigations.

A sterile pyrogen-free generator for ultra-short half-life 81mKr has been developed. During initial loading, the binding efficiency of 81Rb is 90--99%. The count rate during perfusion is 3 x 10(5) counts per minute for a 1,9 GBq (50 mCi) 81Rb generator. The generator has been used for routine and special investigations of lung perfusion and ventilation and for myocardial perfusion during catheterization.

Heart↗
PubMed1979

Is the d an allelic gene of D in the Rh blood group system? A quantitative study using 99mTechnetium-pyrophosphate-labelled antibody (TcLA) method.

This article reports on studies of Rh antigens, such as D, Du and d, using uranyl-labelled antibody (ULA) and TcLA (99mTc-pyrophosphate-labelled antibody) methods for the first time for this purpose. TcLA method proved to be simple in labelling and very sensitive (20--100 times more so than the indirect Coombs test) in the detection of Rh antigen-antibody binding. Results of this quantitative study demonstrate convincingly that the d is not an allelic gene of D but rather the weakest of the series D less than Du less than d. Although the evidence from this study demonstrates clearly that differences between D and d are only quantitative, the authors do not think that the Rh nomenclature should be changed but they do think that the present evidence should be used in regard to the understanding of the allelism in the Rh blood group system. The c is an allelic gene of C as the e is an allelic gene of E; specific test sera detecting every one of these antigens exist and the family studies verify these statements. However, the d is not a distinct antigen as c and e are, even if the pattern of inheritance from family studies, using the existent anti-D serum, would suggest the allelism as probability. That is why in the past the anti-Du and anti-d specific test sera never incidentally found or artificially produced.

Alleles↗
PubMed1978

[Ferrokinetic studies and the prognosis of aplastic anaemia].

The value of ferrokinetic studies for determining the prognosis of patients with aplastic anaemia was assessed 17 patients. Plasma 59Fe clearance, red cell 59Fe incorporation (at 10 days), sacral and hepatic 59Fe uptake (at 6,0 h, measured by surface counting), and 59Fe bone marrow scanning were compared with peripheral blood pancytopenia and marrow cellularity on aspiration and biopsy. In this limited study no statistically significant correlation could be found between ferrokinetic determinations and other criteria of bone marrow failure, although there was a tendency for plasma 59Fe clearance and sacral 59Fe uptake to show some correlation with marrow cellularity on biopsy and with degrees of reticulocytopenia, thrombocytopenia and neutropenia. Ferrokinetic measurements did not differentiate between patients with favourable and those with poor prognoses.

Adolescent↗
PubMed1977

Bone marrow imaging with 59Fe.

Commerically available collimators are not suitable for the visual demonstration of the kinetics of 59Fe, because of its physical properties. A locally designed collimator, that provides integral visual information of the whole body distribution of erythropoietic marrow, is discussed. Wholebody scans of 4 individuals are also included to demonstrate the capabilities of the collimator.

Adult↗