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Biomedical subjects

M Itoh

Publications and source records attributed to M Itoh.

At least 1,117 records · Page 62Linked to original sources
PubMed1981

[Fundamental and clinical studies on cefotaxime in the field of obstetrics and gynecology (author's transl)].

Fundamental and clinical studies were made on cefotaxime (HR-756, CTX), a new cephalosporin antibiotic, with the following results. 1. Cefotaxime was given to 22 patients. Efficacy was excellent in 3 cases, good in 17 cases and poor in 2 cases. No side effects were observed in any cases. 2. Following a single intravenous injection of 1.0 or 2.0 g, the transfer of CTX to the internal genital organs was found to be good. The transfer of CTX to exudate of the dead space of pelvis was also good. 3. The above data demonstrated that CTX is a safe and effective drug.

Adult↗
PubMed1981

[Studies on acid glycosaminoglycans in rabbit uterine cervix and body (author's transl)].

We aimed to measure acid glycosaminoglycans (aGAG) and its composition in nonpregnant and immediately postpartum rabbits uterine cervix and body. aGAG was extracted from the uterine tissues by the modified method of K. Anno (1964) and determined by the carbazole method (Bitter, 1962). Component of aGAG were separated and identified by electrophoresis (0.3 M calcium acetate, veronal buffer, 0.1 M veronal -0.15 M ammonia water, 0.2 M ZnSO4) using acetate cellulose strips. aGAG from uterine cervix and body were separated in three bands which we considered to be hyaluronic acid, heparan sulfate and chondroitin sulfate. Hyaluronic acid was dominant in the cervix, on the other hand the components of aGAG without hyaluronic acid were dominant in the body. This compositional changes were also demonstrated by histochemical digestion test and metachromasia method. We considered these changes as a sign of cervical ripening at term pregnancy.

Animals↗
PubMed1980

Benign subdural effusion in infants.

Twenty cases of infants with computed tomographic low density areas over the frontal lobes that mimicked cortical atrophy are reported. Almost all cases presented with a slight increase in intracranial pressure associated with delayed developmental milestones. Peripheral hypodensity over the frontal lobes disappeared, and the infants' development was essentially normal, in many cases without surgery. The lesion might be called "infantile benign subdural effusion" and should be treated conservatively.

Atrophy↗
PubMed1980

Some devices for computed tomography radiotherapy treatment planning.

Some simple technical devices for radiotherapy planning using computed tomography are reported, including (a) a wide, flat-topped plywood couch, (b) a poultice patch to mark the treatment area, (c) a Plexiglas scan level marker, and (d) reference anteroposterior radiographs using a conventional X-ray TV system.

Humans↗
PubMed1980

Stimulation of insulin release in the absence of extracellular calcium by isobutylmethylxanthine and its inhibition by somatostatin.

It has been suggested that somatostatin may inhibit insulin release by interfering with pancreatic islet calcium uptake. To further investigate this hypothesis, the effect of somatostatin on insulin release was examined under conditions where islet uptake of calcium would be unlikely to occur. The phosphodiesterase inhibitor, isobutylmethylxanthine (0.75 mM), was found to stimulate biphasic insulin release from rat pancreases perfused in vitro in the absence of added extracellular calcium on a background of 0.3 mM EGTA And 8 mM glucose; these results support previous suggestions that methylxanthine phosphodiesterase inhibitors may stimulate insulin release by increasing islet cytosol free calcium through translocation of bound (stored) intraislet calcium. Somatostatin (1.0 muM) completely inhibited both phases of isobutylmethylxanthine-stimulated insulin release. Since uptake of extracellular calcium by islets was unlikely under the present experimental conditions, these results suggest that somatostatin inhibition of insulin release is probably due to interference with a cAMP-dependent translocation of intraislet calcium, or to interference with some other effects of cAMP or an effect of calcium itself rather than to interference with islet calcium uptake.

1-Methyl-3-isobutylxanthine↗
PubMed1980

Properties of the factor VIII after DDAVP (1-deamino-8-D-arginine vasopressin) infusion in normal subjects.

The factor VIII response to DDAVP (1-deamino-8-D-arginine vasopressin) was examined in 6 healthy volunteers. Following intravenous DDAVP infusion, each subject showed a marked increase in factor VIII procoagulant activity (VIII:C), factor VIII related antigen (VIIIR:AG) and von Willebrand factor activity (VIIIR:WF). But there were differences among augmentation index of each activity. Further investigations were performed whether there was a qualitative abnormality in the factor VIII after DDAVP infusion. Between factor VIII activities before and after DDAVP, there was no difference in a thermostability of VIII:C in vitro, gel chromatographic pattern on Sepharose 2B or 4B, a precipitation with concanavalin A (Con A) and a recovery in cryoprecipitate. The increase of VIIIR:AG, however, was mostly brought about by the augmentation of relatively slowly migrating portion as demonstrated by crossed immunoelectrophoresis (CIE). From these results it was assumed that there was no remarkable abnormalities in the factor VIII after DDAVP administration, and the elevated factor VIII could function efficiently in vivo. The findings in cryoprecipitation showed that DDAVP could be applied to blood donation for the preparation of cryoprecipitate.

Arginine Vasopressin↗
PubMed1980

A unique outbreak of Pasteurella multocida in a chronic disease hospital.

An outbreak of Pasteurella multocida infection, involving seven patients on two adjacent wards, has been observed. All seven patients were debilitated and had underlying chronic neuromuscular and/or pulmonary disease and had a tracheostomy tube in situ. The isolates of P. multocida were of the same biotype and serotype, and had an identical antibiogram. Epidemiological studies failed to determine the source of these infections.

Aged↗
PubMed1980

Antisomatostatin gamma globulin augments secretion of both insulin and glucagon in vitro: evidence for a physiologic role for endogenous somatostatin in the regulation of pancreatic A- and B-cell function.

To assess the effects of endogenous somatostatin on pancreatic islet A- and B-cell function, isolated rat islets were incubated in antisomatostatin gamma-globulin to bind endogenously released somatostatin, and the insulin and glucagon secretion of these islets was compared with that of islets incubated in gamma-globulin isolated from nonimmune serum. Islets incubated in antisomatostatin gamma-globulin released significantly more insulin at 4, 8, 16, and 32 mM glucose and significantly more glucagon at 8, 16, and 32 mM glucose, P < 0.05-0.005. For glucose-stimulated insulin release the threshold was decreased, the Vmax was increased, but the apparent Km was unaltered; for glucose-suppression of glucagon release the threshold was increased, maximal suppression was decreased, but the apparent Ki was unaltered. The augmentative effect of the antisomatostatin gamma-globulin was most prominent at 4 mM glucose for insulin release and at 8mM glucose for glucagon release, but was not limited to glucose since both insulin and glucagon release stimulated by arginine were also augmented by antisomatostatin gamma-globulin. These results provide evidence that endogenous somatostatin may act as a physiologic local regulator of both insulin and glucagon secretion and that its effect on insulin and glucagon secretion is dependent on the prevailing glucose concentration.

Animals↗
PubMed1980

Free omental transfer to the lower limbs.

Utilization of a free omental transfer with a skin graft in two lower limbs for soft tissue and skin cover in difficult situations is reported. In 1 patient, it was used to cover open and damaged joints around the ankle, and in the other, for the reconstruction of a circumferential defect in a lower limb. The results were quite satisfactory.

Burns↗