Biomedical subjects

M Itaya

Publications and source records attributed to M Itaya.

74 records · Page 5Linked to original sources

PubMedDate not supplied

[Latentiation of therapeutic drugs. VI. Preparation of l-amino-4-naphtylazoic ambonates of schistosomicides].

With the purpose of obtaining latent forms, with prolonged action and less toxic, of four schistosomicidal 1-amino-4-naphthylazoderivatives synthesized early, embonates of these compounds were prepared by reacting disodium and tetrasodium embonates with hydrochlorides of the four naphthylazoderivatives. The eight embonates thus obtained were sent for biological assays.

1-Naphthylamine↗

PubMedDate not supplied

[Preparation and biological trials of antimalarial sulfa embonates].

With the purpose of obtaining salts of sulfonamides with low toxicity but prolonged action, embonates of seven known sulfonamides, with antimalarila activity, were prepared by double exchange reaction between embonic acid and the antimalarial agents. Six of the seven embonates prepared showed activity against Plasmodium berghei in experimentally infected mice, one of them being significantly more active than the original sulfonamide (sulfadimethoxine).

Antimalarials↗