Biomedical subjects

M Ishigooka

Publications and source records attributed to M Ishigooka.

131 records · Page 8Linked to original sources

PubMedDate not supplied

Hormone profiles and contralateral testicular histology in Down's syndrome with unilateral testicular tumor.

Hormonal profiles and testicular histology were studied in two patients with Down's syndrome with unilateral testicular tumor. Plasma levels of LH and FSH were elevated above normal ranges in both cases. In case 1, plasma testosterone level was abnormally low, but prolactin level in plasma was within the normal range. Case 2 showed elevated concentration of plasma prolactin and normal level of plasma testosterone. The administration of LH-RH resulted in low response of plasma gonadotropins. The response of plasma testosterone to the administration of HCG was abnormally suppressed in both cases. Testicular histology showed reduction of Johnsen score count and tubular diameter, and an increase in wall thickness. These results indicated that male patients with Down's syndrome have an abnormality in hypothalamo-pituitary-gonadal axis.

Adolescent↗

PubMedDate not supplied

Gonadal function and testicular histology in Noonan's syndrome with bilateral cryptorchidism.

Testicular histology and gonadal function were studied in 2 patients with Noonan's syndrome accompanied by bilateral cryptorchidism. Plasma FSH level was elevated above the normal range, but plasma levels of LH, prolactin, and testosterone were within normal ranges in both cases. The administration of LH-RH resulted in abnormally high response of plasma gonadotropins in both cases. The response of plasma testosterone to the administration of LH-RH was poor in case 2, but case 1 showed normal response. Testicular histology showed reduction of tubular diameter, Leydig cells per seminiferous tubules, and spermatogonia per tubule in both cases. The results indicate that bilateral cryptorchid patients with Noonan's syndrome have an abnormality in the hypothalamo-pituitary-gonadal axis.

Child↗

PubMedDate not supplied

Hormone profiles and testicular histology in cryptorchid boys with marker chromosome.

Hormone profiles and testicular histology were studied in two cryptorchid boys with marker chromosome. Plasma testosterone levels were abnormally low in both cases. Plasma levels of gonadotropins and prolactin were within normal ranges in case 1, but case 2 showed decreased concentration of plasma gonadotropins and normal level of plasma prolactin. The administration of LH-RH induced low response of plasma gonadotropins in case 1 and exaggerated response in case 2. The response of plasma testosterone to the administration of hCG was poor in both cases. Testicular histology showed maturation arrest and reduction of tubular diameter and Leydig cells per seminiferous tubules in both cases. Although testicular histology in these cases were similar to those in prepubertal or pubertal boys with cryptorchidism, hormonal disturbances were more severe. It would appear that marker chromosome enhances hormonal alterations.

Adolescent↗

PubMedDate not supplied

Hormone profiles and testicular histology in azoospermic men with Y-autosome translocation and autosomal translocation.

Hormone profiles and testicular histology were studied in azoospermic men with Y-autosome translocation and autosomal translocation. Plasma levels of LH, FSH, prolactin, and testosterone were within normal ranges in these anomalies. The responses of plasma gonadotropins to LH-RH and plasma testosterone to hCG were similar in the two groups. Johnsen score count, diameter of the seminiferous tubules, wall thickness, and Leydig cells per seminiferous tubules were similar in the two groups. It would appear that hormone conditions an alterations are similar in azoospermic men with Y-autosome translocation and autosomal translocation.

Chorionic Gonadotropin↗

PubMedDate not supplied

Effect of experimental cryptorchidism on alpha 1-adrenergic receptors of rat testis.

Alpha 1-adrenergic receptors play an important role in the transport of spermatozoa through seminiferous tubules to the efferent ducts leading to the epididymis. The density of alpha 1-adrenergic receptors in adult Sprague-Dawley rat testis before and during 14 days of experimental cryptorchidism was determined by binding assays with [3H]prazosin in membrane preparations. The number of maximal binding sites (Bmax) per milligram protein began to increase at 7 days after surgery (p < .05). The testicular weight and diameter of seminiferous tubules began to decrease at 5 days after surgery (p < .01). However, Bmax per testis did not differ before and during cryptorchidism. This study demonstrates that the density of alpha 1-adrenergic receptors in rat testis is not affected by cryptorchidism.

Adrenergic alpha-Antagonists↗