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Biomedical subjects

M Ishigooka

Publications and source records attributed to M Ishigooka.

At least 109 records · Page 6Linked to original sources
PubMed1994

Penile block via subpubic space for children who underwent superficial operation of the penis.

Penile nerve block via the subpubic space was performed to relief the postoperative pain of children who underwent superficial surgery of the penis. Thirty-one male children were subdivided into two groups. After dorsal split procedure had been carried out under general anesthesia, 16 patients underwent subpubic penile nerve block (group 1), while 15 patients had no additional anesthetic procedure (group 2). Time to the first postoperative pain in group 1 was statistically longer than that in group 2 (p < 0.05). Most patients in group 1 did not require postoperative analgesics during the first 24 h after surgery. This technique appeared to be effective in relieving the postoperative pain of children who underwent superficial operation of the penis.

Anesthesia, General↗
PubMed1994

Modulation of the urethral pressure by high-frequency block stimulus in dogs.

Nerve conduction block by high-frequency stimulus has been used as a method to modulate the contractile force of skeletal muscles. This paper describes the effect of block stimulus on the modulation of urethral closure pressure in dogs. Tetanic stimulus was applied through a pair of electrodes wrapped about the bilateral pudendal nerves and high-frequency stimulus was superimposed through another pair of electrodes wrapped about 1 cm distalward along the nerves. Urethral closure pressure was measured through a transurethral UPP catheter. High-frequency stimulus over 300 Hz reduced elevated urethral closure pressure, which was induced by tetanic stimulus, up to 30-45%.

Animals↗
PubMed1994

Electrical pelvic floor stimulation by percutaneous implantable electrode.

OBJECTIVE: To describe a clinical experience of chronic pelvic floor stimulation using a percutaneous implantable electrode for the treatment of urinary incontinence. PATIENTS AND METHODS: Pelvic floor stimulation using a percutaneous procedure was performed in 10 patients who were suffering from urinary incontinence due to overactive detrusor function. After implantation of the electrode chronic stimulation was instituted with a portable external electrical stimulator. RESULTS: Four to 16 weeks of maximal electrical stimulation improved urinary incontinence in eight of 10 patients. In two of these eight patients incontinence disappeared as measured subjectively. Urodynamic investigations demonstrated a significantly increased volume at the first unstable contraction (P < 0.01) in all patients. One of 30 electrodes migrated during the follow-up period. CONCLUSION: Inhibition of detrusor overactivity was obtained using this procedure. Response appeared to be constant during chronic stimulation. This procedure appears to provide stable and reliable stimulation for chronic treatment of urinary incontinence and may be an alternative to electrical pelvic floor stimulation.

Adult↗
PubMed1993

Chiral recognition at cytochrome P450 1A2 active site: effects of mutations at the putative distal site on the bindings of asymmetrical axial ligands.

Effects of mutations at the putative distal site of cytochrome P450 1A2 on chiral discrimination for binding (R)-(+)- and (S)-(-)-1-(1-naphthyl)ethylamine (ligand I), (R)-(-)- and (S)-(+)-1-cyclohexylethylamine (ligand II), and (R)-(+)- and (S)-(-)-1-(4-pyridyl)ethanol (ligand III) were studied by optical absorption spectra. The wild-type P450 1A2 exhibited different dissociation constants (Kd) for the R- and S-enantiomers of these ligands. The R/S ratios of the Kd values for ligands I and II were 5.2 and 2.9, respectively, and the S/R ratio for ligand III was 6.0. Mutations at the putative distal site, such as Glu318Asp and Glu318Ala, remarkably enhanced the discrimination: the R/S ratio of the Kd values for ligand I increased from 5.2 to 20-60, while the R/S ratio for ligand II decreased from 2.9 to 0.8-0.9. These remarkable changes in the R/S ratios were not observed with Glu318Asp mutation for ligand III binding, whereas affinities for both enantiomers of ligand III were markedly decreased by the Glu318Ala mutation. Mutation Thr319Ala increased the R/S ratio of the Kd values for ligand I slightly but markedly decreased the R/S ratio of ligand II (from 2.9 to 0.8) and the S/R ratio of ligand III (from 6.0 to 1.0). Similar enhancements of the chiral discriminations were observed with the mutation Lys250Leu at another putative substrate-recognition site. Differences between the R- and S-enantiomers of the standard enthalpy and entropy of ligand III binding were changed most remarkably by the Thr319Ser mutation.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acid Sequence↗
PubMed1993

Therapeutic experience of hyperbaric oxygenation in radiation colitis. Report of a case.

PURPOSE: The usefulness of the hyperbaric oxygenation in a patient with radiation colitis was evaluated. METHODS: The patient had severe bleeding from the large bowel which resulted from a pelvic radiation therapy for prostatic carcinoma and was histologically diagnosed as radiation colitis. Hyperbaric oxygenation therapy consisting of 100 percent oxygen inhalation at two absolute atmospheric pressures 90 minutes daily for 30 days was performed. RESULTS: The treatment succeeded in stopping gross hemorrhage and reversed endoscopic bowel findings. CONCLUSION: The effect of the hyperbaric oxygenation therapy of radiation colitis is elucidated.

Aged↗
PubMed1993

Analysis of regional norepinephrine content in the rabbit bladder after acute electrical pelvic floor stimulation.

Experiments were carried out to evaluate the regional norepinephrine (NE) content of the rabbit bladder after acute electrical pelvic floor stimulation (EPFS). After 30 minutes of EPFS, the content of NE increased significantly in both the bladder base and body (p < 0.05). Furthermore, this increased NE content continued for 1 to 2 hours after cessation of stimulation. The content of NE in the bladder base and body in rabbits treated with alpha-methyl-paratyrosine (AMT) was lower than in the control group. Application of EPFS increased NE content in the bladder even in animals pretreated with AMT. Based on these findings, during EPFS the hypogastric nerve would be presumed to play a significant role in bladder inhibition. Increased synthesis of NE probably did not play an important role in elevation of NE content after EPFS.

Animals↗
PubMed1993

Polyps of the prostatic urethra. Report of four cases.

We described 4 cases of polyps of the prostatic urethra. Three of them had adenomatous polyp with prostatic epithelium and 1 showed polypoid urethritis. These lesions were worth noting as a cause of hematuria, dysuria or hematospermia. Polyps or papillary lesions of the prostatic urethra appear to be more common than have been suspected. Careful attention should be paid to the prostatic urethra in patients with persistent painless hematuria.

Adult↗
PubMed1993

Unilateral diffuse adrenal hyperplasia masquerading as aldosterone-producing adenoma in primary hyperaldosteronism.

We report a case of primary hyperaldosteronism due to unilateral diffuse hyperplasia. Unilateral adrenalectomy resulted in an improvement of hypertension and hyperaldosteronism. Six months after surgery, the plasma aldosterone level and plasma renin activity remained normal, but blood pressure returned to an abnormally high level. We have reviewed the literature and discuss the pathogenesis of this disorder.

Adenoma↗
PubMed1993

Technique of percutaneous electrode implantation for electrical pelvic floor stimulation.

A modified technique of electrical pelvic floor stimulation is described in detail. Six patients suffering from detrusor urinary incontinence underwent percutaneous electrode implantation for electrical pelvic floor stimulation. By this procedure adequate muscle contraction was obtained with a significant rise in urethral closure pressure. Detrusor reflex thresholds were increased in 5 of 6 patients at the initial stimulation. Percutaneous implantation appears to be an easy and noninvasive technique. This method provides stable and adequate effects on the pelvic floor structure and may be used in chronic electrical stimulation.

Adult↗
PubMed1993

Y-autosome translocation associated with azoospermia.

Y-autosome translocation is a rare condition. We report here a case of balanced Y-autosome translocation associated with azoospermia. Nineteen cases of a balanced Y-autosome translocation associated with azoospermia are reviewed, and hormone condition and testicular histology are discussed.

Adult↗
PubMed1993

An unusual profile of endocrine study in a patient with pre-Cushing's syndrome.

A unilateral adrenal tumour was incidentally detected in a 39-year-old woman with no characteristic features of Cushing's syndrome. Basal levels of glucocorticoids were within normal limits. However, abnormal pattern of plasma cortisol and ACTH was observed. The dexamethasone suppression test and the metyrapone test showed also abnormal response. Adrenocortical scintigram demonstrated high accumulation of the radiopharmaceutical in the tumour region alone. Final diagnosis was "pre-Cushing's syndrome" and a solitary adenoma was removed from the left adrenal gland.

17-Hydroxycorticosteroids↗
PubMed1993

Incidence of anal incontinence after long-term follow-up of patients treated by ureterosigmoidostomy.

Twenty-eight patients who had been treated with ureterosigmoidostomy after radical cystectomy were examined with special reference to anal incontinence. In the present series, 17 out of 28 patients (60.7%) had daytime and/or nighttime anal incontinence. In these patients preoperative function of the external and sphincter was considered to be sufficient. Anal incontinence occurred immediately after operation in only 3 patients. Incontinence emerged at an average duration of 2.6 years after ureterocolonic anastomosis. Incidence of anal incontinence after ureterosigmoidostomy appeared to be influenced by aging.

Aged↗
PubMed1993

Electrical pelvic floor stimulation in the management of urinary incontinence due to neuropathic overactive bladder.

Electrical pelvic floor stimulation employing a portable functional electrical stimulation system with percutaneously indwelling electrodes was carried out to improve detrusor urinary incontinence. Cyclic stimulation using negative going pulse trains of 20 Hz was applied 3 to 6 times daily to the bilateral pudendal nerves distributing to the pelvic floor muscles for the purpose of strengthening these muscles, including the urethral sphincter, and simultaneously, suppressing detrusor overactivity and increasing cystometric capacity. Electrical training for 4-8 weeks resulted in an improvement of urinary incontinence in five of six patients. In two of six cases incontinence had subjectively disappeared. Urodynamic investigations demonstrated an increase in detrusor reflex threshold and less tendency for abortive detrusor contraction. No apparent complications were encountered during these periods. This procedure appears to be efficient for the management of patients with detrusor incontinence who respond poorly to conservative therapies.

Adult↗
PubMed1993

Nerve conduction velocities and hair concentrations of trace elements in haemodialysis patients.

Nerve conduction velocities and hair concentrations of trace elements were studied in 19 male patients with chronic renal failure undergoing haemodialysis. Both motor and sensory nerve conduction velocities were significantly lower in haemodialysis patients as compared to controls (p < 0.001). Calcium and aluminium concentrations were significantly higher in patients (p < 0.01), however, vanadium and arsenic levels were significantly lower in patients (p < 0.01). In concentrations of copper and zinc there was no significant difference between patients and controls. There were no significant correlations between hair concentrations of trace elements and nerve conduction velocities except between calcium concentration and sensory nerve conduction velocity. These facts suggest that nerve conduction velocities are not influenced by changes of trace element concentrations in hair in patients with chronic renal failure undergoing haemodialysis.

Adult↗