Bacterial urease as a factor in human disease.
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Biomedical subjects
Publications and source records attributed to M Ip.
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A new minor surgical procedure for ascites has been devised wherein a specially designated one way pressure activated valve is implanted to create a permanent peritoneo-venous shunt. The normally closed valves opens only when the peritoneal pressure rises 3-5 cm higher than the intrathoracic venous pressure thus preventing backflow of blood and closing the valve should the venous pressure rise from the over-infusion of ascitic fluid. The procedure has been performed on 45 patients but nine were terminal at the time of surgery. Prolonged relief of ascites occurred in 28 of 37 cases.
A case of meningitis due to an unusual organism, Haemophilus aphrophilus in an adult is described. In spite of rapid clearance of the organism from the cerebrospinal fluid with intravenous cefotaxime, fever persisted over 8 days of therapy and infection was complicated by hydrocephalus. H. aphrophilus meningitis is uncommon and has not been previously reported in an adult male.
Streptococcus pneumoniae isolates from clinical specimens during the period 1993-1997 at the Prince of Wales Hospital, Hong Kong, were analysed by the antibiotic resistance profiles, the distribution of serotypes, specimen types, and patient demographics. 1,229 non-duplicate S. pneumoniae isolates were evaluated; 84% from the respiratory tract, 11% from blood and cerebrospinal fluid and the remainder from body fluids and pus swabs. The percentage of S. pneumoniae of reduced penicillin susceptibility was 38.6%, and the percentage resistance to erythromycin, chloramphenicol, co-trimoxazole and tetracycline were 40.4, 43.2, 54.9 and 77.8%, respectively. The organism was isolated from patients of all age groups, 14.6% from children aged below 10 years, half of whom were from children aged 2 years or below. 57.0% were from elderly patients aged above 60. The male to female ratio was 2.5:1. Isolates with reduced penicillin susceptibility were seen significantly more so in children under 10 than in those aged 11 or above (52 versus 36%, p < 0.0001). A diverse range of serotypes was obtained in the penicillin-susceptible isolates whilst those of reduced susceptibility were confined to serotypes 23F, 19F, 6B, 14 and 9V.
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