Search PubMed⌕ Search

Biomedical subjects

M Inagaki

Publications and source records attributed to M Inagaki.

At least 451 records · Page 25Linked to original sources
PubMedDate not supplied

Enzyme properties of monoamine oxidase in the frontal cortex and liver of the gerbil (Meriones unguiculatus).

1. Enzyme properties of monoamine oxidase (MAO) in the frontal cortex and liver of the gerbil were investigated using 5-hydroxytryptamine (5-HT), benzylamine (Bz) and tyramine (Tyr) as substrates. 2. The Km values of MAO towards the three substrates were almost similar to the values in other species. The Vmax value of MAO towards Bz was much lower than the value towards 5-HT. 3. In the inhibition studies with selective MAO-A and MAO-B inhibitors, clorgyline and deprenyl, deamination of 5-HT, Bz and Tyr in both tissues was induced by MAO-A alone, MAO-B alone and both forms of the enzyme, respectively, indicating the same substrate specificity as that in rats. 4. The apparent proportion of MAO-A to MAO-B activities in the gerbil liver was approximately 6:4, whereas MAO-A in the frontal cortex of the gerbil was exclusively predominant, consistent with the previous data in the golden hamster which belongs to the same family as the gerbil.

Animals↗
PubMedDate not supplied

Early onset muscular dystrophy with autosomal dominant heredity. Report of a family and CT findings of skeletal muscle.

The clinical features and muscle pathology in a female infant and her mother with early onset and slowly progressive muscular dystrophy (MD), possibly transmitted through autosomal dominant inheritance, are described. The mother exhibited multiple joint contractures at birth. The daughter had mild proximal muscle weakness at 2 3/12 years old. The muscle biopsy specimens from both patients showed myopathic changes with evidence of fiber necrosis and regeneration. Computed tomographic (CT) findings of their skeletal muscles suggested that proximal muscles were involved at an early stage, with later gradual involvement of generalized muscles, without a characteristic selectivity pattern in thigh muscles. This may possibly be a clinically benign and distinct variant of MD with a slowly degenerating pattern of skeletal muscles on CT.

Adult↗
PubMedDate not supplied

Relief of chronic burning pain in Fabry disease with neurotropin.

Neurotropin, an extract from the inflamed skin of vaccinia virus-inoculated rabbits, was effective in the relief of sharp or burning pain induced by pyrexia, hot weather, bathing, or exercise in 2 siblings with Fabry disease. Neither neurotropin nor carbamazepine mono-therapy relieved the episodic colicky pain in 1 patient; however, therapy with both drugs eliminated the pain completely. This result suggests that the mechanisms underlying the analgesic actions of both drugs may be complementary in ameliorating the pain of Fabry disease, even though the mechanism underlying the pain has not been clearly elucidated.

Adolescent↗
PubMedDate not supplied

Prognosis and MRI after ischemic stroke of the basal ganglia.

The clinical courses and long-term prognoses in 16 young patients with infarctions of the basal ganglia were evaluated and the recent magnetic resonance imaging findings in 9 of them were examined. Only 5 of 14 patients (35%) had motor sequelae, 4 had hemiparesis, and 1 had gait disturbance. Secondary dystonia occurred in 1 patient. Magnetic resonance imaging disclosed a circumscribed lesion in the basal ganglia, as reflected by T2 high- and T1 low-intensity signals, in all patients. The abnormal region on T2-weighted images usually was more extensive than that observed on T1-weighted ones. The hemiplegic patients each had an area of abnormal intensity in the internal capsule or corona radiata with relatively high signals on the T2- and proton-density-weighted images. Mild to moderate asymmetric atrophy of the midbrain on the side ipsilateral to the stroke lesion was observed in 8 of 9 patients. The mechanism involved may be remote transsynaptic neuronal death of the substantia nigra, as well as Wallerian degeneration of the pyramidal tract.

Adolescent↗