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Biomedical subjects

M Imamura

Publications and source records attributed to M Imamura.

At least 721 records · Page 40Linked to original sources
PubMed1984

Response of gastric acid and gut hormones in biliary tract reconstruction using an interposed jejunum or ileum in dogs.

Ten dogs were used to investigate the changes in gut hormones; gastrin, secretin, GIP, and gut-GLI, as well as gastric acid secretion after a test-meal loading following a cholecystoduodenostomy interposing a portion of the jejunum or the ileum. Although the changes in the response of plasma gut hormones to the test-meal were observed, the amount of acid output after the biliary tract reconstruction did not differ from that before the operations in either the jejunal interposition cholecystoduodenostomy or the ileal interposition cholecystoduodenostomy. Therefore, from the standpoint of gastric acid secretion, they are both recommendable procedures for biliary tract reconstruction. It was difficult, however, to interpret the change of gut hormone release in relation to gastric acid secretion. It is presumed that the release of gut hormones after the reconstructive procedure is mainly affected by the part of the small intestine which is used for the reconstruction.

Animals↗
PubMed1984

Lymphoid cell subpopulations infiltrating into autologous rat tumors undergoing rejection.

Lymphoid cell subpopulations infiltrating into autografts of methylcholanthrene-induced sarcomas in rats immunized with autologous tumor cells were identified in terms of immunohistochemical and cytofluorographic techniques using various monoclonal antibodies raised against different classes of rat lymphohemopoietic cells. These antibodies included in this study directed to rat T-cell antigens corresponding to mouse Lyt-1 (RLyt-1) and Lyt-2,3 antigens (RLyt-2) and to W3/25 antigen expressed on a particular subset of rat T-cells with helper function, as well as to rat granulocyte-macrophage-specific antigen (RGM-1). Histological studies demonstrated that the autografts of highly antigenic tumors introduced to the primary hosts were completely rejected following massive immigration of lymphoid cells into the tumor sites, which was not observed in progressively growing, minimally antigenic tumors. These lymphoid cells found within regressing highly antigenic tumor autografts were identified mostly to be T-cells bearing RLyt-1 (approximately 70%), and more than two-thirds of these T-cells expressed RLyt-2 antigen. In contrast to T-cells, macrophages and B-cells, each of which could be recognized by the presence of either RGM-1 antigen or immunoglobulin on their cell surfaces, appeared to have a minimal role in the rejection of autochthonous tumors, as reflected by their less frequent appearance within the tumor tissues during the rejection process.

Animals↗
PubMed1983

Association of dysgerminoma and gaucher's disease.

A 22-year-old woman presented with splenomegaly and pancytopenia of over two years' duration. A splenectomy was performed because of a suspicion of Gaucher's disease. At the time of operation a left ovarian tumor was found and was removed. A diagnosis of Gaucher's disease was made on the basis of massive infiltration of histiocytes with typical cytoplasmic striations in the spleen, liver, and bone marrow. The ovarian tumor was characterized by a monotonous, diffuse proliferation of large, rounded cells and was diagnosed as dysgerminoma. The association of Gaucher's disease and malignant tumors is rare, only several cases have been reported in the English literature. An additional feature of this case was the appearance of histiocytes showing the characteristic cytoplasmic striations of Gaucher's cells in the stroma of the tumor.

Adult↗
PubMed1983

Frequency and antigenicity of type C retrovirus-like particles in human placentas.

Seventeen placentas from normal Japanese women, obtained from 15 full term gestations and at 2 earlier gestational periods, were observed by electron microscopy for the presence of type C retrovirus-like particles. Immature free and budding particles were found in 16 placentas including those obtained pre-term. Free virus-like particles were seen in the intercellular spaces and within the lysosomes of syncytiotrophoblasts of the chorionic villi. Forms budding from syncytiotrophoblasts were found in 3 cases. Coincident data with the electron microscopic observations were obtained by immunohistological methods. Specific positive staining with antisera against heterogeneic whole murine leukaemia virus were seen within the cytoplasm of trophoblastic cells both in and along the basal lamina.

Antigens, Viral↗
PubMed1983

Selection of operation for concomitant gastric and duodenal ulcers.

In an attempt to determine the most appropriate procedure for surgical treatment of concomitant ulcers, gastric secretion and pathological findings were studied. Acid and pepsin secretion in concomitant gastric and duodenal ulcers was significantly higher than in case of gastric ulcer alone, and similar to the secretion seen with duodenal ulcer. Thus, vagotomy was considered an appropriate procedure. In terms of the depth, histologic activity and exposure of large blood vessels at the base of the ulcers, concomitant gastric ulcer involved serious lesions compared with concomitant duodenal ulcer, indicating that distal gastrectomy was required. Therefore, we recommend vagotomy and hemigastrectomy for concomitant ulcers, in order to preserve the physiological function of the stomach, as much as possible.

Adult↗
PubMed1983

Gastric acid secretion and gastrointestinal hormone release after biliary reconstruction procedures.

The changes in gastric acid secretion and gastrointestinal hormone release were studied after biliary tract reconstruction to investigate the mechanism of gastric acid hypersecretion after a biliary diversion procedure. At follow-up, gastric acid output in patients with Roux-Y choledochojejunostomy was significantly higher than before the operation. In contrast, in patients with jejunal interposition choledochoduodenostomy, which does not bring about biliary diversion, acid output increased slightly after the operation. Moreover, at follow-up, acid output in the Roux- Y group was slightly higher than it was in the interposition group. Although the fasting levels of plasma gastric inhibitory polypeptide were almost the same in both groups, the loading of a test meal elicited a lower response of plasma gastric inhibitory polypeptide in patients with the Roux- Y procedure than in those with the interposition procedure. Therefore, it is assumed that gastric inhibitory polypeptide, as an enterogastrone after a biliary reconstruction procedure, might have some influence on gastric acid secretion.

Adolescent↗
PubMed1983

Effect of intrasplenic injection of allogeneic bone marrow cells on the survival of lethally X-irradiated mice.

Radiation chimeras in mice were induced by intrasplenic injection of allogeneic bone marrow cells instead of intravenous injection. Interestingly, the survival time in X-irradiated BALB/c mice inoculated intrasplenically (i.s.) with bone marrow cells from C3H/He mice was markedly prolonged as compared with that in X-irradiated BALB/c mice inoculated i.v. with bone marrow cells from C3H/He mice. However, when C57BL/6 mice were used as donors, a significant difference between i.s. injection and i.v. injection has not been found in survival time at 60 days after X irradiation. On the contrary, when bone marrow cells from BALB/c or C57BL/6 mice were injected into X-irradiated C3H/He mice, i.s. injection gave longer survival days to recipients than did i.v. injection. Based on testing their chimerism, it was suggested that lymphoid cells of donor origin were predominantly identified in almost all BALB/c or C3H/He recipients which were inoculated i.s. with bone marrow cells from C57BL/6 mice. However, somewhat incomplete chimerism was observed when the C3H/He to BALB/c donor-recipient combination was used and vice versa.

Animals↗
PubMed1983

[Immunohistological studies on the identification of T cells and T cell subsets infiltrating in human stomach cancer tissues].

T cells and T cell subsets in human gastric cancer tissues were identified using the immunoperoxidase technique with anti-T cell monoclonal antibodies (Leu-1, Leu-2, Leu-3 and Leu-4), anti-HLA-DR(Ia) monocronal antibody, and anti-Ig sera. The majority of lymphocytes infiltrating into gastric cancer tissues were Leu-1 and Leu-4 positive T cells; they consisted of a Leu-2 positive T cell subset (Tc/s) and a Leu-3 positive T cell subset (Th/i). Leu-2 positive T cells infiltrated the gastric cancer tissues of 6 patients with a moderate or marked degree of lymphocyte infiltration; Leu-3 positive T cells infiltrated these tissues of 11 patients. These results show that the degree of T cell and T cell subset infiltration may effect the host-tumor relationship.

Adenocarcinoma↗
PubMed1983

[Effect of various reconstructions of biliary tract upon secretion of gastric acid and gastrointestinal hormones in dogs].

Experimental studies were carried out to investigate the effect of various biliary tract reconstructions upon the secretion of gastric acid and gastrointestinal hormones. Jejunal interposition cholecystoduodenostomy with a short jejunal segment (Group-I), jejunal interposition cholecystoduodenostomy with a long jejunal segment (Group-II), and Roux-en-Y cholecystojejunostomy (Group-III) were constructed in seventeen Heidenhain pouch dogs. Peptic ulcer was only observed in 2 out of 7 dogs of Group-III. Although food-stimulated gastric acid output did not differ significantly in all the groups, the amount of gastric acid reached a peak much later and remained elevated in Group-III compared with that in other groups. The changes in plasma gastrin, gastric inhibitory polypeptide and total glucagon are regarded to be affected by the length of the jejunum excluded from the stream of chyme and the direct contact of the jejunum with bile. It is concluded that the pattern of acid secretion is more important than its volume for the mechanism of peptic ulceration in Roux-en-Y cholecystojejunostomy.

Animals↗
PubMed1983

[Relationship between T cell infiltration in breast cancer tissues and prognosis].

The relationship between the degree of T cell infiltration in cancer tissues and prognosis was studied in 26 patients with breast cancer. The degree of T cell infiltration was divided into 4 groups according to the number of infiltrating T cells. There was a good correlation between the degree of T cell infiltration and the survival period or disease-free period. It may be clinically useful to check the degree of T cell infiltration in cancer tissues for predicting the prognosis of patients with breast cancer.

Adult↗
PubMed1983

[Experimental study on acute gastric ulceration in rat--including influence of obstructive jaundice and vagotomy].

Prognostic indicator for acute gastric ulceration was experimentally investigated using water immersed and restrained rats, with special interest in influence of obstructive jaundice and effect of vagotomy. The results obtained are as follows: Intragastric pH and gastric mucosal potential difference (PD) faithfully reflected the ulcer index. This shows that continuous monitoring of these two parameters may be of clinical use as indicator for acute gastric ulceration in critically ill or postoperative patients. Water immersing and restraint stress ulcer may be caused by imbalance between gastric offensive and defensive factors as a result of progressively increasing gastric secretion and progressively deteriorating gastric mucosal barrier. Gastric ulceration was enhanced in rats with obstructive jaundice, probably because of compromised defensive factor. Prophylaxis of acute gastric ulceration with or without obstructive jaundice may not be attained by vagotomy alone; an adequate maintenance of defensive factor seems to be also necessary.

Acute Disease↗
PubMed1982

Evolution of infectious mononucleosis into Epstein-Barr virus carrying monoclonal malignant lymphoma.

A monoclonal malignant lymphoma was diagnosed in a 30-month-old Japanese boy, who, since the age of 12 months, had had chronic, recurrent infectious mononucleosis manifested by repeated episodes of severe cough and high fever accompanied by marked lymphadenopathy and hepatosplenomegaly and high serum Epstein-Barr virus (EBV) antibody titres. The diagnosis of Burkitt's lymphoma was made when a cervical lymph-node biopsy specimen revealed massive proliferation of immature B-cells with starry-sky histiocytes. These lymph-node cells were characterised by a translocation between chromosomes 10 and 17. There were approximately 9 EBV genome-equivalents per cell. Most cells were positive for nuclear antigen (EBNA); early antigen (EA) and viral capsid antigen (VCA) were also detected. The presence of EBV was supported by finding that the cell-free lymph-node extract transformed cord-blood lymphocytes into EBNA-positive blast cells. The proportion of EA-positive and VCA-positive cells increased rapidly in culture for 24 h, then the positive cells degenerated rapidly and completely. The cells also contained numerous herpes-type virus particles. The child improved considerably with cytostatic treatment and has been in remission for 2 years.

Antibodies, Viral↗