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Biomedical subjects

M Iio

Publications and source records attributed to M Iio.

At least 397 records · Page 22Linked to original sources
PubMedDate not supplied

Enhanced killing effects of caffein post-treatment in ultraviolet-light irradiated mouse lymphoma cells: is cAMP a mediator of the effects?

Effects of post-treatment with caffein, cyclic adenosine 3':5'-monophosphate (cAMP) and N6, O2-dibutyryl cAMP (dbcAMP) were investigated in ultraviolet light (UV)-irradiated mouse lymphoma L5178Y cells. Under conditions where UV or each chemical alone caused only slight cytotoxic effects, caffein post-treatment showed clear synergistic effects in cell killing but not for cAMP or dbcAMP. Subsequently, a mutant clone resistant to cAMP was isolated. This mutant was supposed to be deficient in cAMP-mediated cellular functions. Using the mutant cells, it was found that these cells were also sensitive to caffein post-treatment as wild cells after UV-irradiation. The results imply that the enhanced killing effects by caffein post-treatment in UV irradiated cells is not mediated by cAMP.

Animals↗
PubMedDate not supplied

Magnetic resonance of liver tumors: a preliminary report.

Early experience in magnetic resonance (MR) images of the liver tumors is reported, based on 25 cases examined by a 0.35T superconducting machine (Magnetom, Siemens) using the spin echo technique. All main liver tumors were demonstrated as high intensity areas of varying degree in the spin echo image with a TR of 1,600 msec and a TE of 70 msec. All of them had prolonged T2 and T1. The smallest lesion detected on MR was 0.8 cm in diameter in the cases of multiple liver cysts and 1.5 cm in the cases of a solitary solid tumor. Normal vasculature of the liver was well-delineated, despite a far longer acquisition time compared with respiratory holding period. MR is a promising modality for liver imaging.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

Multilocular cystic hepatocellular carcinoma.

We report an unusual case of multilocular cystic hepatocellular carcinoma. The patient was a 42-year-old woman without liver cirrhosis but who had three multicystic mass lesions in the liver. Transcatheter arterial embolization was very effective and a survival time of more than 19 months was obtained.

Adult↗
PubMedDate not supplied

Intraarterial digital subtraction portography in patients with liver tumors.

Intraarterial digital subtraction portography (IADSP) via the superior mesenteric artery was performed in 50 patients with liver tumors. In most cases IADSPs provided images as good as conventional arterial portography through the superior mesenteric artery and they produced important information as to whether patients should be treated by transcatheter arterial embolization, surgical resection or chemotherapy. IADSP helps to reduce the examination time, the number of films and contrast material used, as well as the pain suffered by patients.

Humans↗
PubMedDate not supplied

Intraarterial digital subtraction angiography of peripheral arteries with isotonic contrast material.

Intraarterial digital subtraction angiography (IADSA) of peripheral arteries with isotonic contrast material, which was prepared by diluting meglumine amidotrizoate (65% Angiografin), was performed in ten patients. In six, both IADSA and conventional screen-film arteriography were performed for comparison. Painless peripheral arteriography was achieved by IADSA with isotonic contrast material. Five IADSAs were safely done on an outpatient basis. Visualization of arteries by IADSA was satisfactory, but the details of smaller arteries were better shown by screen-film arteriography. Visualization of faint stains was better in IADSA. The authors believe that IADSA with isotonic contrast material is a method of choice for the diagnosis of vascular diseases and tumorous conditions of extremities, as well as for the purpose of preoperative vascular mapping. It is safely performed with smaller dose of contrast material on outpatient basis, and with less discomfort and cost for the patient.

Angiography↗
PubMedDate not supplied

Brain tumors with ipsilateral cerebral hemiatrophy.

Brain tumors with secondary ipsilateral cerebral hemiatrophy are so rare that only seven cases have been reported in the literature. Three new cases are presented and the clinical findings in all 10 cases are reviewed. The diagnostic value of computed tomography (CT) is emphasized. The authors conclude that nodular high-density lesions located deep in the cerebrum and showing slight contrast enhancement on CT may be associated with ipsilateral cerebral hemiatrophy in young male patients with slowly progressive hemiparesis, dementia, and personality change. In such cases, early diagnosis of germinoma and subsequent radiotherapy may prevent unnecessary surgery.

Adolescent↗
PubMedDate not supplied

Positron emission tomography in systemic lupus erythematosus: relation of cerebral vasculitis to PET findings.

A 12-year-old Japanese girl with systemic lupus erythematosus is described. Positron emission tomography (PET) showed low attenuation in the right frontotemporal area at relapse, which disappeared at remission. Findings on electroencephalography coincided with those on PET. On x-ray CT there were no specific findings. The PET findings were thought to be due to cerebral vasculitis.

Brain↗
PubMedDate not supplied

Sclerosing hepatic carcinoma: a report of a case treated with a transcatheter arterial embolization.

Sclerosing hepatic carcinoma (SHC) is one of the variant primary liver carcinomas and is characterized by intense fibrosis which surrounds slender cords of neoplastic cells. We report on a 53-year-old male patient with SHC describing the radiological findings and clinical course after a transcatheter arterial embolization. To our knowledge, this was only the second reported case of SHC in Japan.

Embolization, Therapeutic↗
PubMedDate not supplied

Bilateral synchronous renal cancer.

Six cases of concurrent bilateral renal cancer are reported. These cases represented 3.7% of 163 renal cancers in our institute during the period 1965-1983. Five of the six cases were examined by CT. One earlier case received only selective renal arteriography. Three patients who had extrarenal metastases at the initial presentation showed poor prognoses and died within a year. The other three showed better prognoses. One had bilateral multiple renal cell cancer which was not associated with von Hippel-Lindau disease. One survived 4.5 years after unilateral nephrectomy and chemotherapy. One received unilateral total embolization combined with partial embolization of the contralateral kidney and is still well 1.5 years after initial diagnosis, without evidence of remote metastases. The smaller tumors of bilateral renal cancer were early in stage and were detected by CT. CT is thought to be the best method for detecting small asymptomatic tumors amenable to conservative surgery. Angiography is thought to be essential for the planning of embolization and partial nephrectomy. Although it is an interesting question whether each tumor has a multicentric origin or whether one is a metastasis of another, no criteria seem to exist which are completely satisfactory for making this distinction.

Aged↗
PubMedDate not supplied

Internal jugular phlebectasia in children.

Two pediatric cases with internal jugular phlebectasia which showed specific clinical and radiographic features are described. CT and venography were useful in the diagnosis. Differential diagnosis of cervical masses which enlarge with Valsalva maneuver are also discussed with a review of the literature.

Child↗
PubMedDate not supplied

Intraarterial digital subtraction arteriography in the management of renal tumors.

Nine patients with renal tumors were studied by intraarterial digital subtraction arteriography (IADSA). Embolization was performed in six patients. IADSA was evaluated on the following practical points: vascular mapping, renal vein visualization, and embolization. Vascular mapping by IADSA was satisfactory in eight patients. The limitation of the field of view was the major restricting factor, and a second opacification was necessary in two cases. One case with multiple renal arteries was unacceptable as the lowest renal artery was missed. Renal vein visualization by IADSA with renal artery injection was not reliable due to misregistration artifacts caused by bowel gas. Embolization with IADSA was satisfactory. Significant reductions in contrast load and procedure time were achieved. IADSA was found to be an effective tool in vascular mapping and embolization of renal tumors. Selective renal arteriography to visualize renal veins was better performed with conventional techniques.

Angiography↗
PubMedDate not supplied

Mesenteric varices: an entity with specific clinical, angiographic features.

Eight Japanese patients with mesenteric varices were diagnosed by angiography. All patients suffered from portal hypertension and had a history of previous abdominal surgery or peritonitis. The mesenteric varices of these patients were thought to be related to adhesion. Of the eight patients, five showed hepatic encephalopathy. None of the patients had a history of massive lower-gastrointestinal bleeding. All mesenteric varices were opacified in the portal phase of superior mesenteric arteriograms. To study the superior mesenteric artery, 50-60 ml of 76% Urografin was injected after infusion of prostaglandin E1 or F2 alpha. Regarding patients treated in the early part of the study, a vasodilator was not used and the contrast dosage was modest. In all eight patients, the mesenteric varices communicated with the systemic venous circulation through the gonadal veins. In seven cases, the mesenteric varices on the right side of the mesenteries drained into the right gonadal veins which flowed into the inferior vena cava (IVC). In the remaining case, the mesenteric varix on the left side drained into the left gonadal vein which flowed into the left renal vein. In three patients with right-sided varices, venous blood sampled from the right gonadal vein and from the distal and proximal IVC showed a high concentration of ammonia in the right gonadal vein and step-ups between distal and proximal IVC.

Adult↗
PubMedDate not supplied

Bone scintigraphy in Maffucci syndrome.

Maffucci syndrome is a congenital, non-hereditary mesodermal dysplasia associated with multiple enchondromas and hemangiomas. The high risk of development of malignant tumors is well-known. A case of Maffucci syndrome in a 68-year-old man who suffered from multiple malignant degeneration and who was given a bone scintigraphic examination is reported with radiological and pathological findings. The scintigraphic findings are different for two histological different chondrosarcomatous lesions. It seems that uptake of Tc-99m MDP increases with the degree of calcification rather than whether the lesion is benign or malignant.

Aged↗
PubMedDate not supplied

Nuclear magnetic resonance computed tomography: the first clinical experience in Japan.

The first clinical experience of Nuclear Magnetic Resonance Computed Tomography (NMR-CT) in Japan is reported here. The first series of patients include 37 with lesions in the brain, 5 in the thorax and 28 in the abdomen. The main advantages of NMR-CT are as follows: No ionizing irradiation exists. Sagittal and frontal tomograms are easily produced. Chemical status of tissue is shown by relaxation times (T1, T2) and proton density. Vascular structures are easily recognized and the blood flow can be estimated. Less bone artifacts are produced compared with X-ray CT. (XCT)

Abdominal Neoplasms↗
PubMedDate not supplied

The value of the modified high temporal resolution phase analysis for the detection of myocardial infarction.

Recently, cardiac nuclear medicine, especially gated RI cardiac blood pool scan has been improved remarkably, and now phase analysis has been introduced. We have developed a new modified phase image, with the objective of improving the time resolution, by displaying a special range of phase angles (about pi/3 radian) with 16 color scales, which correspond to the ventricles. Compared with the conventional method, the high resolution phase image improved the sensitivity of diagnosis of the region of myocardial infarction. The sensitivity of the modified phase image was 91% (10 cases our of 11), whereas that of the conventional method was 27% (3 cases out of 11).

Adult↗
PubMedDate not supplied

Gelatin gel beads as an embolic agent.

Gelatin gel beads (GGB) is a compound of a long-chain polypeptide cross-linked with glutaraldehyde. It has been produced exclusively for embolic purposes. The object of the tests reported here was to determine the efficacy of GGB as an embolic agent in dogs as initial studies with rats had shown no acute toxic reaction. Eight dogs were used as subjects. Transcatheter embolization of one kidney in each animal was performed with a suspension of 500 mg of GGB and contrast material. The embolized kidneys were re-examined after one to five weeks. Embolized vessels remained occluded up to five weeks after the procedure. There was mild granulomatous reaction which started to organize at about the third week. The availability of GGB in various sizes when mixed in an isotonic solution makes it unique when compared with other forms of embolic agents. As this agent has now been shown to be a safe and reliable agent in dogs, it can now be used for testing in human subjects.

Animals↗
PubMedDate not supplied

ECG-gated NMR-CT for cardiovascular disease.

We have developed an ECG-gated NMR-CT, and used it with 16 patients. The saturation recovery images are not able to separate heart muscle from the blood pool, but in inversion recovery images, heart muscle can be differentiated from the ventricles. The region of myocardial infarction is revealed as wall thinning and/or wall motion abnormality. From the two-gated inversion recovery images (the end-diastole and end-systole images) we obtained, we evaluated a wall motion abnormality in the left ventricle, and calculated the ejection fraction of the left ventricle. This information was then compared with the findings of a nuclear medicine study carried out one week interval and which included 10 of the 16 patients tested with the ECG-gated NMR-CT. The wall motions in both methods are well correlated, with the exception of the inferior wall. The values of the ejection fraction in the NMR image were moderately low, but two modalities showed a satisfactory correlation (r = 0.85).

Adult↗