Effects of oral administration of nortriptyline, imipramine and citalopram on morphine hot-plate and tail-immersion analgesia in rats.
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Analgesia↗
Biomedical subjects
M Ibba
Publications and source records attributed to M Ibba.
Relationship between plasma and brain concentrations of Denzimol and its anticonvulsant and neurotoxic effects in the rat.
The relationship between plasma, brain and cerebellum concentrations of Denzimol a new anticonvulsant agent, and its anticonvulsant and neurotoxic effects were studied in the rat. Sixty minutes after oral administration, a high brain/plasma concentration ratio of 10:1 was found. Mean plasma, brain and cerebellum half-lives of the drug were 8.4, 7.1 and 9.2 hr, respectively. The anticonvulsant activity of the drug was examined by maximal electroshok seizures (MES). Neurotoxicity was determined both by the rotarod performance test and by behavioural observation. Denzimol was effective against MES, in the ranges of 0.8-5 micrograms/ml and 10-50 micrograms/ml for plasma and brain concentrations, respectively, without causing clear signs of neurological toxicity. It is concluded that the anticonvulsant and neurotoxic effects of denzimol are correlated to its plasma and brain concentrations.
Animals↗
Differential antagonism of denzimol to various components of metrazol-induced seizures in rats and mice.
The antagonism of various components of maximal metrazol-seizures and the induction of ataxia have been studied in mice and rats by comparing Denzimol to 10 standard antiepileptic drugs. The data were analyzed by Cluster and Principal Components Analysis. Denzimol, phenytoin, carbamazepine and AD-810 showed an antagonistic effect on tonic but not on clonic seizures regardless of the animal species. Barbiturates, benzodiazepines and valproic acid, on the other hand, antagonized the whole pattern of metrazol-seizures. The selective activity of Denzimol and phenytoin against tonic seizures was also confirmed from literature data, which reported the activity of these compounds against bicuculline, thiosemicarbazide or picrotoxin induced convulsions.
Administration, Oral↗
Enhancement of diazepam activities induced by denzimol in mice.
Denzimol, a new anticonvulsant drug, enhances the depressant and antimetrazol activities of diazepam in mice, in a dose and time-dependent fashion. The depressant and anticonvulsant activities of phenobarbital were not affected by Denzimol. It is suggested that Denzimol induces an increase in the number of the benzodiazepine receptors, and that such increase might be responsible for the enhancement of the diazepam's activities.
Animals↗
Effects of drugs used in the therapy of detrusor hyperactivity on the volume-induced contractions of the rat urinary bladder.
In this study we examined the effects of the drugs most commonly utilized in the therapy of overactive detrusor, on the volume-induced contractions of rat urinary bladder. Anticholinergics such as propantheline bromide and emepronium bromide, as well as oxybutynin decreased the amplitude of the voiding contractions after intravenous (i.v.) administration in a dose-dependent way. These anticholinergics, on the other hand, generally increased the frequency of the contractions. Nifedipine dose-dependently reduced the amplitude of the contractions. Flavoxate induced a dose-related decrease in the frequency without effects on the amplitude of the peaks. Its main metabolite 3-methylflavone-8-carboxylic acid (MFCA) was inactive after i.v. administration. Terodiline was active on the amplitude and apparently on the frequency of the voiding contractions. The alpha-adrenoceptor antagonist prazosin, as well as indomethacin, inhibited only the frequency of the voiding contractions. All the drugs active in reducing the frequency of the voiding contractions after i.v. administration, proved effective also after intracerebroventricular (i.c.v.) injection. The model of the volume-induced contractions of rat urinary bladder, seems to be a useful tool to evaluate in vivo the effects of a compound on the bladder, allowing the possibility of distinguishing among antimuscarinics and calcium antagonists, which peripherally decrease bladder contractility, and other drugs inducing a decrease in the frequency of the voiding reflex acting on the micturition centre(s) in the central nervous system (CNS).
Animals↗
Primary spindle cell tumor of lymph node with "amianthoid" fibers: a histological, immunohistochemical and ultrastructural study.
A primary mesenchymal spindle cell tumor with amianthoid fibers was observed in an inguinal lymph node of a 70-year-old woman. With immunohistochemical stains the cells were positive for muscle actin and negative for desmin. Transmission electron microscopy (TEM) showed intracytoplasmic bundles of microfilaments with focal densities, profiles of rough endoplasmic reticulum, and basementlike material indicative of myofibroblastic and/or smooth-muscle cell differentiation. At scanning electron microscopy (SEM) the tumor was organized into slitlike spaces containing red blood cells. Amianthoid fibers showed a strong positivity for actin at their edge with a central negative core; by TEM they appeared to be formed of 200 nm thick crystallized collagen fibers surrounded by actin microfilaments arranged in a palisading fashion. The immunohistochemical and ultrastructural findings of the proliferating myoid cells suggest a possible derivation from smooth-muscle vascular cells. Collagen fiber aggregation and actin filament dismission might be secondary to anoxia due to vascular obliteration or disruption.
Actins↗