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Biomedical subjects

M Ia Ratner

Publications and source records attributed to M Ia Ratner.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[Histomorphological tubulointerstitial changes in progression of chronic glomerulonephritis].

The role of histological changes associated with primary types of glomerulonephritides in progression of chronic glomerulonephritis (CGN) is analysed. It is shown that CGN progression acceleration occurs much more frequently if chronic renal failure arises within 7 years since the disease onset, in the presence of concomitant tubulointerstitial changes (TIC)in unfavorable morphological types--mesangiocapillary glomerulonephritis and focal-segmental hyalinosis/ sclerosis. It was found that more frequent occurrence of CGN accelerated progression in unfavorable morphological types and TIC depends on the presence of unfavorable clinical types--active nephritic and nephrotic-hypertensive types (classification of M. Ya. Ratner et al.). In TIC there were primarily unfavorable clinical types which contribute to accelerated progression of CGN. This relationship is explained by involvement of factors belonging to the above clinical types in the mechanism of the morphological changes. In these clinical types CGN accelerated progression takes place irrespectively of the presence of TIC and unfavorable morphological types.

Adolescent↗
PubMedDate not supplied

[The role of tubular interstitial changes in the genesis of the rapid progression of chronic glomerulonephritis].

The observation over 146 cases of compensated chronic glomerulonephritis (CGN) led the authors to the conclusion that there is a relationship between rapidly progressive CGN, onset of chronic renal failure 5 years after CGN diagnosis, the existence of tubulointerstitial changes (TIC) and CGN clinical pattern. Rapidly progressive CGN seems to arise primarily against TIC, in active nephritic and nephrotic-hypertensive types. In these clinical types CGN occurred more often than in TIC, while the disease takes a more favourable course in the alternative clinical types than in TIC absence. Thus, a clinical type appeared more reliable predictor of rapidly progressive CGN than TIC. The relations between clinical types and TIC explain more frequent occurrence of rapidly progressive CGN in the presence of the above morphological changes.

Chronic Disease↗
PubMedDate not supplied

[A clinico-morphological analysis of the efficacy of therapy in chronic glomerulonephritis using prednisone, a cytostatic, an anticoagulant and an antiaggregant].

Four-component therapy (chlorbutin 0.2 mg, prednisone [correction of prednisolone] 60 mg, curantyl 400 mg/day per os, i.v. heparin 10,000 U twice a day) was given for 9-36 months to 76 patients with chronic glomerulonephritis (CGN). A statistically significant lowering of proteinuria was achieved irrespective of CGN clinicomorphological variant. As indicated by remission frequency and normalization of urinary osmotic concentration, efficacy of the above treatment is related to a clinical CGN type. Because clinical and morphological CGN types are correlated, the disease morphology and treatment effect are associated. The treatment proved effective in nephrotic mesangioproliferative, mesangiocapillary glomerulonephritis, focal-segmental glomerular sclerosis, active nephritic mesangiocapillary glomerulonephritis and inactive nephritic mesangioproliferative and mesangiocapillary glomerulonephritis. Nephrotic-hypertonic focal-segmental glomerulosclerosis and mesangiocapillary glomerulonephritis were resistant to therapy.

Anticoagulants↗