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Biomedical subjects

M Ia Ratner

Publications and source records attributed to M Ia Ratner.

At least 37 records · Page 2Linked to original sources
PubMed1990

[The catamnestic assessment of the efficacy of combined pathogenetic therapy in patients with different clinico-morphological variants of chronic glomerulonephritis].

In 70 patients with functionally compensated chronic glomerulonephritis (CGN), the disease outcomes were elucidated after the use of the 4-component therapy (a cytostatic, an anticoagulant, an antiaggregation agent and prednisone). The therapy appeared much more effective in the nephrotic types of CGN than in the active nephritic types. Remission was only attained in a subgroup of patients with the active types: with an early stage of the maximally active type of mesangiocapillary CGN. In the nephrotic type CGN, the therapy was effective in short-phase disease and ineffective in long persistence of that syndrome. In the nephrotic types, mesangioproliferative CGN as well as the short-phase nephrotic syndrome irrespective of the morphological type turned out predictors of a favourable outcome following the treatment. No effect can be predicted in focal segmental hyalinosis/sclerosis accompanied by arterial hypertension and the protracted nephrotic syndrome.

Adolescent↗
PubMed1990

[Prognostic signs of accelerated progression of nephrotic types of chronic glomerulonephritis].

A prognostic value of some clinical and morphological signs was followed up in 43 patients with chronic glomerulonephritis concurrent with the nephrotic syndrome versus 85 with other clinical types of the disease. There was a statistically significant incidence of disease progression in combination with arterial hypertension, resistance of the nephrotic syndrome over 12 months and detection of sclerosing renal glomeruli and interstitium within 2 years after onset of the disease. The protracted course of the nephrotic syndrome is a precursor of occurrence of chronic renal failure. With less prolonged phases of the syndrome there is evidence for a long-term period of functional compensation. Occurrence of arterial hypertension early in the disease, as early renal parenchymal sclerosis, fails to predict the rates of chronic renal failure development. In the absence of these factors, the possibility of prompt disease progression may be rejected in all likelihood.

Chronic Disease↗
PubMed1989

[Clinical and morphologic predictors of the progress of chronic glomerulonephritis].

Observation over 183 patients with a morphologically verified diagnosis of chronic glomerulonephritis (CGN) made it possible to establish on a mathematic basis a highly significant relationship between the disease progress and the clinical and morphological disease patterns. In the active nephritic patterns and in the nephrotic-hypertonic pattern, chronic renal failure (CRF) occurred in the majority of the patients within the first 5 years. Meanwhile in the inactive nephritic pattern and in the nephrotic pattern, a corticoid-sensitive one, characterized by the phasic course, CRF could not almost be seen over up to 20 years after the disease onset. As far as the morphological patterns are concerned, focal-segmental glomerular hyalinosis/sclerosis turned out most unfavourable. In patients with this pattern, CRF was diagnosed during 5 years in almost half of the patients. The mesangio proliferative and membranous patterns appeared most favourable. The incidence of CRF during 5 years after the disease onset, common to the definite clinical patterns, did not depend on the concomitant morphological pattern. Provided there were sclerotic lesions throughout 2 years after the disease onset, CRF occurred in 65% of the cases for 10 years, whereas with their lack in 9% of the cases. The most important predictors of CRF were as follows: the clinical pattern of CGN and the presence of sclerotic lesions in the renal biopsy specimen. Of definite significance might be the morphological pattern of CGN.

Adult↗
PubMed1988

[Disordered permeability of the glomerular filter for middle- and high-molecular serum proteins in various morphologic types and stages of chronic glomerulonephritis].

Investigation of glomerular filter permeability for serum immunoglobulins and albumins in 83 patients with chronic glomerulonephritis (CGN) with nephrotic proteinuria has shown that in mesangioproliferative glomerulonephritis permeability for IgM is rare, for IgA and IgG moderately raised; in a marked but not maximum degree of permeability for albumins, it is characterized by considerable variability. In maximum permeability for albumins there is a tendency to the reduction of the ratio of IgA and IgM clearances to albumin clearance, and variability of these indices. In membranous CGN the structure of nephron permeability for serum proteins is identical but it remains unchanged with a sharp rise of albumin fractional clearance. In mesangiocapillary CGN permeability for IgM is more frequent and enhanced for IgG. in focal-segmental glomerular hyalinosis/sclerosis and diffuse-fibroplastic GN permeability for IgG is considerably raised unrelated to a degree of permeability for albumins. Sclerotic changes are accompanied by elevated permeability for IgG.

Adolescent↗
PubMed1987

[Several homeostatic renal functions in hypertensive and nephrotic syndromes of chronic functionally compensated glomerulonephritis].

Homeostatic renal functions in nephrotic syndrome (NS) and arterial hypertension were studied the data on 240 patients with functionally compensated chronic glomerulonephritis (CGN). Benign arterial hypertension did not make a considerable effect on renal functions. In NS there was a selective decrease in the functions, particularly affected in the tubulointerstitial component (TIC) of CGN (concentration and ammonium secretory functions). These functions were affected to the maximum in proteinuria over 9.0 g/day. The NS adverse effect on renal transport processes was not dependent on the TIC presence. In CGN accompanied by moderate proteinuria, even a moderate decrease in renal concentration function or a considerable decrease in ammonium secretory function suggested the TIC presence. Against a background of the NS the presence of CGN TIC could be supposed only in the detection of maximum urine osmolarity not exceeding 600 mmol/l.

Adolescent↗
PubMed1985

[Further study of the indications for combination cytostatic-anticoagulant-antiaggregation-corticosteroid therapy of chronic glomerulonephritis].

One hundred and twenty-five patients with different morphoclinical variants of chronic glomerulonephritis (CGN) were examined for the efficacy of cytostatic-anticoagulant-antiaggregation (CAA) therapy. The treatment appeared successful in 47 (37%) of patients. The efficacy largely depended on the degree and intensity of the disease clinical manifestations as well as on a dramatic increase in the permeability of the glomerular filter for medium- and high-molecular serum proteins and on superimposition of sclerotic transformation of renal glomeruli. The use of CAA therapy was most successful in GN whatever superimposition of fibroplastic transformation. The treatment was abortive in prolonged (more than 12 months) persistence of pronounced proteinuria combined with hematuria and/or arterial hypertension, in the nephrotic-hypertonic pattern of GN irrespective of the disease stage, in disease patterns manifesting themselves chiefly by hematuria and negligible proteinuria.

Adolescent↗
PubMed1984

[Morpho-clinical variants of chronic glomerulonephritis and their significance for the evaluation of the severity of the disease].

The study of the morphological, clinical and functional manifestations of compensated chronic glomerulonephritis (CGN) in 317 patients revealed the advantage of the morphoclinical variants as compared to the morphological types for the evaluation of the gravity and prognosis of the disease. The morphoclinical variant means the combination of the morphological and clinical types. It was found that the morphoclinical variants of CGN determine the probability of the tubulointerstitial component, which deteriorates the prognosis of the disease more precisely than its morphological types. Renal dysfunction is more closely connected with the morphoclinal variant of CGN than with the morphological type. The data obtained are in favour of developing a morphoclinical classification of CGN on the basis of the morphoclinical variants of the disease.

Adolescent↗