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Biomedical subjects

M Ia Lovkova

Publications and source records attributed to M Ia Lovkova.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Features of the elemental composition of medicinal plants, synthesizing phenolic compounds].

A total of 52 species of medicinal plants capable of synthesizing phenolic compounds were subjected to mass-scale screening for 24 chemical elements. The screening was performed by atomic absorption spectrometry in combination with spectrophotometric detection. The plant species tested were found to accumulate groups of two to ten chemical elements (Fe, Cr, Cu, Co, Mn, etc.), which are known cofactors and activators of many enzymes of phenol metabolism. Some of the plant species tested are overconcentrators of Cr, Co, Mn, I, and other chemical elements. The possibility of the use of these plants in the treatment and prophylaxis of disorders of the microelement metabolism is discussed.

Phenols↗
PubMedDate not supplied

[Chemistry of medicinal plants (review)].

Data on the chemical composition related to synthesis of physiologically active substances (alkaloids, terpenoids, glycosides, phenolic compounds, etc.), and accumulation of individual elements or groups of five to ten elements (e.g., Cr, Co, Mn, and Zn) in medicinal plants were reviewed. Chemical features of medicinal plants serve as an integral determinant of their species specificity and pharmacological properties and enabling their wide use in medical practice. The relationship between the synthesis of physiologically active substances and accumulation of elements is mediated by several levels of molecular regulation.

Plants, Medicinal↗
PubMedDate not supplied

[Relationship between celandine isoquinoline alkaloids with macro- and microelements].

Numerous linear and nonlinear correlations between the contents of alkaloids and mineral elements in the aerial parts and roots of greater celandine (Chelidonium majus L.) were revealed by means of correlation and regression analyses. These relationships became more significant with the transition from the sum of alkaloids to individual groups or fractions, which included compounds of similar compositions. The mathematical models describing the regulation of alkaloid metabolism by some mineral elements (Ba, Mg, Sr, Co, Cr, Zn, etc.) were developed in the analytical form. These models were tested in experiments with geochemical modeling using Zn.

Alkaloids↗
PubMedDate not supplied

[Evaluation of correlation between the content of alkaloids and chemical elements in Washington lupin (Lupinus polyphyllus Lindl.) besed on statistical analysis and mathematical simulation].

A considerable number of linear and nonlinear correlations between concentrations of quinolizidine alkaloids and concentrations of K, Ca, Mg, Ba, Zn, Cu, Ni, and V were found in lupin seeds and leaves by using methods of correlation and regression analysis. Mathematical models of regulation of alkaloid metabolism by these chemical elements were constructed. The models of regulation were considered separately for individual plant organs.

Alkaloids↗
PubMedDate not supplied

[Genetic aspects of the relationship between isoquinoline alkaloids and mineral elements in greater celandine (Chelidonium majus L.)].

Interrelations between the total content of isoquinoline alkaloids, concentrations of quaternary protoberberines and benzophenanthridines, and the amount of K, Cu, Co, Al, Ba, and Zn in aerial parts of individual celandine plants were revealed, within a single cenopopulation, using correlation analysis and regression analysis. Mathematical models describing the regulation of isoquinoline metabolism by some of the mineral elements were obtained in the analytical form. The results suggest that this process is genetically determined.

Alkaloids↗
PubMedDate not supplied

[Theoretical bases of optimization of the modes of postharvest treatment of alkaloid-synthesizing medicinal plants].

The method of disks in combination with thin-layer chromatography and spectrophotometry was used for a comparative evaluation of the efficiency of different methods of fixing and fermentation of medicinal plants (leaves). Medicinal plant species capable of synthesizing alkaloids of various structural types (isoquinoline derivatives including benzophenanthridines, bisbenzylisoquinoline, quaternary protoberberines, and aporphines, as well as steroid and diterpene alkaloids) were used. The methods of fixing and fermentation were shown to exert a substantial effect on both the qualitative and quantitative composition of alkaloids. This difference in the alkaloid composition was found to represent the superposition of three independent and, to a large extent, opposite processes: catabolism of alkaloids, interaction of alkaloids with each other, and resynthesis from primary precursors. The use of different methods of fixing and fermentation provides activation or inhibition of these processes, thereby making it possible to carry out target-oriented correction of the alkaloid composition of the medicinal plants studied.

Alkaloids↗
PubMedDate not supplied

[Role of elements and physiologically active compounds in the regulation of synthesis and accumulation of indole alkaloids in Catharanthus roseus L].

Effects of various elements (Co, Ni, Zn, W, Mn, Cr, B, Mo, Fe, and V), natural and synthetic auxins, cytokinins, and gibberellin on biosynthesis and accumulation of indole alkaloids was studied at increasing concentrations in the model system of Madagascar periwinkle seedlings (Catharanthus roseus L.). The main types of concentration dependences for the effect of physiologically active compounds under study were evaluated. A possible mechanism of the influence of Zn and auxin on this process was partly clarified. The compounds were shown to modulate various stages in the biosynthesis of monomeric indole alkaloids (catharanthine and vindoline).

Catharanthus↗
PubMedDate not supplied

[Regulatory role of elements in the formation and accumulation of alkaloids in Papaver somniferum L. seedlings].

The effects of 12 elements on the formation and accumulation of isoquinolines were studied in opium poppy seedlings (Papaver somniferum L.). Three types of concentration dependences of the effects of the elements under study were determined. The elements served as activators (Co, Mo, W, Cr, and Cu) or inhibitors of these processes (B, Fe, V, Mn, and Ca). The molecular mechanisms of action of these regulators are discussed. The optimum concentrations of Co and Mo were tested under combined treatment conditions with these elements.

Alkaloids↗