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Biomedical subjects

M I Titova

Publications and source records attributed to M I Titova.

At least 19 recordsLinked to original sources
PubMed2002

[Disorders of protein C anticoagulant system in various clinical conditions].

A study was carried out on activity of protein C4 in 73 surgical patients (coagulation test, reagents of company PEHAM). The reduction in activity of protein C was observed in patients with focal liver lesion related to disturbance of protein formation function. This percent of disturbances in protein C system is more often found in patients with vascular pathology. This is explained by the mechanism of its action and implication of vascular endothelium into the process. Disturbances in patients with injury infection are stipulated with activity of C and S proteins and availability of mutant factor V--factor Leiden in patients with diabetes. In the first days after surgical intervention the activity of C protein was much reduced. The obtained results emphasize the importance of research in the system of protein C in surgical patients.

Blood Coagulation Disorders↗
PubMed2001

[Experience in the use of vessel due F (sulodexide) in patients with suppurative-necrotic forms of diabetic foot without critical ischemia].

AIM: To evaluate effectiveness of sulodexide in patients with pyonecrotic complications of diabetic foot. MATERIAL AND METHOD: Sulodexide was given to 15 patients which were examined for blood fibrinogen, foot tissues saturation with oxygen, microbic contamination of the wound tissue. In addition, ultrasound dopplerography of foot arteries, laser doppler flowmetry were performed. RESULTS: Fibrinogen in peripheral blood fell, arteriovenous shunting diminished, capillary blood flow and oxygen saturation of the tissues improved. CONCLUSION: Even early sulodexide treatment is effective at different stages of the pathological process in diabetic patients with severe pyonecrotic lesion of the lower limbs as it recovers microcirculatory blood flow.

Diabetic Foot↗
PubMed2000

[Current methods of morphological and hemostasiological analysis of reparative process in wounds making use of information programs].

Objective rapid morphological and hemostasiological methods for evaluating the reparative process in the wound making use of PC software have been developed for identification of stages of reparative process in the wound under conditions of modern surgical service. Cytran consultative software has been developed for evaluation of phases of reparative reaction in the wound. Coagulogram consultative software was used for identification of reparative reaction phases in the wound from hemostasiological changes in tissue factors of granulation tissue in the wound. Cytran and Coagulogram software were used under clinical conditions in 105 patients with open, suppurative, and burn wounds for characterization of the reparative reaction phases.

Blood Coagulation↗
PubMed2000

[Thermal trauma in a combination with respiratory tract burn].

The detection rate of microbial contamination of burn wounds after flame burn was studied in dynamics to 3 weeks in 56 patients forming 2 similar groups: basic--with thermo-inhalation lesions (TIL) and control--without TIL. General area of skin burns in all the patients was less than 50% of the body surface, on average it was 40%, the area of deep burns was 23%. Cytological and bacteriologic methods were used for study microphlora in the sputum and in bronchoalveolar lavage. There were 186 cases of wound microbial contamination (gram-negative microorganisms--64.4% cases, gram-positive--34%, pathogenic fungi--1.6%). In 80% cases the microphlora of the wounds was polymicrobial, in 47% cases the microphlora were detected on the second week. Microphlora was detected 2 times more often in the basic group than in the control, corresponded to skin burn area; the greatest exceeding of critical level of wound contamination was revealed on the first 2 weeks. In TIL besides wound contamination, polymicrobial microphlora revealed in tracheobronchial tree, presented on the first 2 weeks with association of gram-positive and gram-negative microorganisms, combining on week 3 with fungal phlora. Early leukocytosis, not reducing during first 3 weeks of the study, due to intoxication by burn products, occurred in TIL. Early lymphopenia in TIL was the sign of resistant immunodeficiency.

Adolescent↗
PubMed1996

[Hemostasis disorders after resection of liver and approaches to their prevention and correction].

Second- or third-degree dysfunction of hepatocytes was the most frequent (47.9%) disorder in the hemostasis system on the first-second days after extensive resection of the liver, whereas after economic resection this disorder was observed in only 5.5% patients. Intraoperative blood loss of more than 3 liters is fraught with hemorrhages and hepatorenal insufficiency in the postoperative period. Such blood loss is complicated by coagulopathic states presenting as 1) hepatocyte dysfunction of the second-third degree, 2) hypoxia and decreased production of blood clotting factors, and 3) variants of the DIC syndrome. Study of the genesis of postoperative coagulopathies after resection of the liver and development of pathogenetically-based methods of drug correction, together with introduction of novel instrumental methods affecting the intensity of local and total hemostatic reaction, helped reduce 2.5 to 3 times the total blood loss.

Adolescent↗
PubMed1995

[Clinical significance of the determination of protein C dependent disorders of hemostasis in surgical patients].

Diagnostic value of protein C measurements was investigated in 159 surgical patients with diseases of the liver, great vessels, and wound infection. Protein C antigen was detected by ELISA with specific antibodies to protein C. The changes of protein C antigenic activity correlated with severity of hepatic disorders. Inhibition of protein C synthetic activity went on in parallel with a fall in pseudocholine esterase concentrations. This suggests feasibility of protein C measurements for examination of protein production by the liver. Characteristics and location of the lesions in great vessels were also related to protein C antigen levels. The fall in this antigen quantity was observed in patients with purulent wound infection. The greater the fall, the more serious the patient's condition became.

Blood Coagulation Disorders↗
PubMed1993

Poly(2-hydroxyethyl methacrylate) particles for preoperative endovascular occlusion of extensive angiodysplasias.

The application of superselective endovascular occlusion in vascular radiology has broadened the scope of possible radical surgery of giant angiodysplasias by reducing considerably the risk of severe haemorrhage during the surgery. Occlusion was performed on 229 patients using spherical and cylindrical particles of porous poly(2-hydroxyethyl methacrylate). The treatment of a patient suffering from angiodysplasia of the pelvis is described as an example. The first day following endovascular occlusion a hypercoagulation reaction developed, with a decrease of both the level of fibrinolysis and of anticoagulant factors. This was mainly due to a decrease of the level of antithrombin III and activation of the factor XIII indicating a strong tendency of intravascular thrombosis. During the third day, the hypercoagulation reaction increased. However, on the fifteenth day, parameters of the haemostasis system were close to normal values. Only the activity of the factor XIII remained high suggesting the stabilization and the organization of fibrin clot in the embolized blood vessel territory.

Angiodysplasia↗
PubMed1991

[Characteristics of vascular changes and hemostatic reaction of the body in nonspecific aorto-arteritis].

Laboratory criteria to differentiate diagnostically nonspecific aorto-arteritis with other forms of obliterating arterial diseases have been established by hemostatic, morphological and cytological investigations. Factors of plasmic hemostasis and platelet functional activity are able to indicate etiological cause of aortal lesion in noninvasive clinical examination. Identification of platelet--forming reaction type shows that nonspecific aorto--arteritis is characterized by "red" platelet formation and fibrinization of the body. Atherosclerotic stenosing proceeds by "white" thrombus formation associated with enhanced activity of platelet adhesion and aggregation.

Adolescent↗
PubMed1989

[Effect of controlled bacteria-free medium on the course of the wound process in patients with chronic venous insufficiency of the legs complicated by trophic ulcer].

Treatment in a controlled abacterial medium was applied to 102 patients with venous ulcer of the lower limbs. The course of the wound process was studied on the basis of objective examination methods (microbiological, cytological, morphological, study of the activity of tissue hemostasis factors). The results showed that a controlled abacterial medium causes favourable changes in the course of the wound process and allows the trophic ulcer to be prepared for operation in a short period of time (9-12 days).

Bacterial Infections↗