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Biomedical subjects

M I Sorokina

Publications and source records attributed to M I Sorokina.

At least 19 recordsLinked to original sources
PubMed1994

[Treatment of peritonitis complicated by multiple organ insufficiency].

Comparison evaluation of the methods of treatment was based on the analysis of the results of management of 347 patients with general purulent decompensated peritonitis with polyorganic insufficiency. The efficacy of closed drainage in 98 patients, continuous flow irrigation (dialysis) in 126, stage programmed irrigation and inspection of the abdominal cavity in 99, and open drainage in 24 patients was compared. The causes of peritonitis were: complications after acute surgical diseases (in 156 cases), in planned operations (59), and in obstetrical and gynecological diseases (132). Most of the patients were brought to the clinic from other hospitals because of unsuccessful treatment of peritonitis and absence of means for performing hemodialysis and management of polyorganic insufficiency. The incidence of the last-named reached 71.0 to 91.0% in the different groups of patients. In monotypic complex treatment, stage programmed irrigation was marked by a much lesser number of abscesses and other complications and a lower mortality (20.2%) as compared to flow irrigation (30.0%, closed drainage (27.5%), and open (laparostomy) treatment (37.5%). Despite the very serious contingent of patients, total mortality (27.0%) in the application of the indicated methods was quite low.

Anti-Bacterial Agents↗
PubMed1991

[Generalized suppurative peritonitis in patients with destructive forms of acute appendicitis].

The authors undertook comparative analysis of the results of treatment, the number and intensity of postoperative pyo-inflammatory complications, and the mortality rate in a group of 51 patients with generalized purulent peritonitis of appendicular origin in various methods of abdominal cavity cleansing: closed drainage of the abdominal cavity (group I, 10 patients); continuous peritoneal lavage (group II, 15 patients), cleansing of the abdominal cavity in stages (group III, 26 patients). Any type of cleansing did not exclude the development of purulent complications during treatment, the whose number grew with the increase in the period between the appendectomy and the onset of the disease. Complications developed in 23 patients (45%). Their frequency and intensity were, however, much less when the abdominal cavity was lavaged in stages, which enable the number of cases of adhesive obstruction and the formation of abscesses between the loops to be reduced markedly. A progressive septic process and poly-organic insufficiency were the main causes of death. The mortality rate was 30; 26.6 and 11.5%, respectively, in groups I, II, and III.

Acute Disease↗
PubMed1990

[Stage-by-stage lavage of the abdominal cavity in the treatment of diffuse suppurative peritonitis].

The article generalizes experience in the treatment of 65 patients with generalized purulent peritonitis at the toxic and terminal stage with the use of active cleansing of the abdominal cavity by step-by-step lavage (1 to 12 times). The authors studied changes of the flora, the indices of immunological and nonspecific reactivity and central hemodynamics, the parameters of water spaces and electrolytes, and the condition of hemostasis from the peak of peritonitis to recovery. The cleansing step-by-step lavages of the abdominal cavity in generalized purulent peritonitis reduce the frequency and intensity of surgical complications, make it possible to avoid generalization of the septic process or its further development, and are, on the whole, an effective method of treatment. They may be considered to be method of choice in patients with polyorganic insufficiency.

Adolescent↗
PubMed1989

[Antibacterial therapy in disseminated purulent peritonitis].

Analysis of 156 records relating to patients at the age of 15 to 85 years with extended purulent peritonitis of the surgical and gynecological genesis (the toxic phase, VI category ASA) showed that combination of programmed sanitation laparotomy and intensive antibacterial therapy performed as short-term courses before, during and after the operation with an account of the information on the nature of the microbial associations and antibioticograms was an efficient procedure in treatment of severe peritonitis. It was indicated in treatment of patients with polyorgan deficiency. When the surgical treatment was adequate early antibiotic therapy allowed to decrease the number and intensity of postoperative complications: the frequency of abscessing in the abdominal cavity and formation of intestinal fistulas lowered 2 and 1.5 times respectively. Such a decrease was also observed in asthenic patients with lowered protective reactions to development of new infectious foci in the abdominal cavity complicating the peritonitis process. It was also possible to prevent with that procedure the infection generalization and development of peritoneal sepsis. With application of the procedure to such patients (20 per cent) lethality lowered 2-fold.

Abscess↗
PubMed1982

[Ultrastructural bases of heart failure in the early period of the prolonged crush syndrome].

Histological, electron microscopic, and physiological studies on the myocardium of rats and dogs in severe forms of compression syndrome (6-9 hours of compression and 2-4-7 hours after decompression) revealed three groups of morphological changes underlying cardiac insufficiency: (1) predominantly microcirculatory disorders with mild changes in cardiomyocytes detectable in bradycardia. Under these conditions the development of cardiac weakness may be based on both calcium overloading and reflectory weakening of the heart activity; (2) combination of microcirculatory disorders with marked hypoxic damage of the cardiomyocytes structure detectable under conditions of tachycardia may be an independent cause of the cardiac muscle weakness; (3) changes in the structures of cardiomyocytes responsible for nervous impulses conduction: sarcolemma and its derivatives. Under this condition, the probable cause of cardiac disorders may be electrolyte imbalance accompanying postcompression toxemia.

Animals↗
PubMed1981

[Microbial flora sensitivity to antibacterial agents in chronic pyelonephritis patients who have had acute kidney failure].

The analysis of antibioticograms of patients with a history of chronic pyelonephritis and acute renal insufficiency is presented. It was found that the synergistic effect observed with the use of gentamicin in combination with carbenicillin or ampicillin with cephaloridin provides a decrease in the therapeutic doses of the drugs with a purpose of elimination of their side action.

Acute Kidney Injury↗