Endothelial-dependent vasodilation is impaired in patients with systemic sclerosis, as assessed by low dose iontophoresis.
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Acetylcholine↗
Biomedical subjects
M I Jayson
Publications and source records attributed to M I Jayson.
The medical treatment of rheumatoid arthritis.
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Adrenocorticotropic Hormone↗
Collagenolytic enzyme systems in human intervertebral disc: their control, mechanism, and their possible role in the initiation of biomechanical failure.
Changes in the macromolecular matrix of the intervertebral disc may predispose to biomechanical failure of the disc. Such changes would involve extracellular enzymes capable of altering the collagen and proteoglycan of the disc matrix. In this study, extracts from homogenates of both annuli fibrosi and nuclei pulposi of human lumbar discs were found to contain neutral collagenolytic, gelatinolytic, and elastinolytic enzymes in all samples assayed. The specific activity of the collagenase was higher in extracts from nuclear than from annular tissue, a difference not seen with gelatinase or elastase. The collagenase was present as both a latent and active enzyme, the other enzymes being fully active. Human intervertebral discs therefore contain enzymes capable of degrading their extracellular macromolecular matrix.
Age Factors↗
The micro-circulation in systemic sclerosis.
Damage to the micro-circulation forms a fundamental part of systemic sclerosis (SS) and may be responsible not only for the various vascular features of the disease but also for the connective tissue changes. Figure 1 suggests a possible mechanism integrating these various microvascular changes. Various parts of this scheme may be amenable to therapeutic intervention particularly if undertaken before irreversible vascular damage has occurred. Studies are in progress examining various ways of treating the microvascular disease, examining their effects on the vascular problems and on the progress of the disease.
Blood Vessels↗