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Biomedical subjects

M I Jayson

Publications and source records attributed to M I Jayson.

At least 199 records · Page 11Linked to original sources
PubMed1975

Acute knee joint rupture after yttrium 90 injection.

Two cases of acute rupture of the knee joint are reported after the intra-articular injection of radioactive yttrium 90. It is suggested that this may be a complication of intra-articular radioactive injections.

Arthritis, Rheumatoid↗
PubMed1975

Lack of correlation of synovial histology with joint damage in rheumatoid arthritis.

Twenty-two patients with rheumatoid arthritis (RA) involving the knee were studied. The systemic features of the disease were graded and the extent of knee involvement was quantified in terms of the clinical, radiological, and arthroscopic appearances. Adequate synovial biopsies were obtained from 21 patients. In these patients no correlation could be found between the severity of any of the features on histological examination nor between any of these features and the extent of local joint damage, inflammation, or the severity of the systemic disease.

Arthritis, Rheumatoid↗
PubMed1975

Serum copper and caeruloplasmin in ankylosing spondylitis, systemic sclerosis, and morphea.

Studies of serum copper and caeruloplasmin were performed in patients with ankylosing spondylitis, systemic sclerosis, and morphea. Mean levels of both were raised significantly in ankylosing spondylitis, with the greatest increases in the worst cases. In patients with systemic sclerosis there was a significant increase in the mean level of caeruloplasmin, but not of copper, although both were raised in the 2 patients with the most aggressive disease. No alterations were found in patients with morphea. The values in the patients overlapped considerably with the values in the control subjects. It is thought that the increase in serum copper is probably secondary to the increase in caeruloplasmin which occurs as a nonspecific response to inflammation.

Ceruloplasmin↗
PubMed1975

Organ culture of adult human articular cartilage. I. The effect of hyperoxia on synthesis of glycosaminoglycan.

Adult human articular cartilage was maintained in organ culture for eight days in 20 per cent and 95 per cent oxygen. The higher oxygen tension proved to be lethal to the cartilage, whereas the mean number of surviving chondrocytes in 20 per cent oxygen was 91 per cent of the total. Specimens were cultured with radioactive sulfate (Na235SO4) for two days and the uptake of sulfate (DPM) at 95 per cent oxygen was significantly lower than at 20 per cent oxygen. There was a positive correlation between DPM and uronic acid, and between DPM and DNA (p less than 0.001), but not between DPM and dry weight.

Animals↗
PubMed1975

Organ culture of adult human articular cartilage. II. The differential rate of glycosaminoglycan synthesis in layers of articular cartilage matrix.

Adult human articular cartilage was maintained in culture for three days and labelled with 35SO4 for the first 48 hours. The explants were sectioned horizontally on the cryostat, and the sections from the top, middle, and deep layers analyzed separately. Autoradiographs were prepared from every twentieth section. The DNA content in each of the three layers was of the same order, but the sulfate uptake and uronic acid content were considerably reduced at the surface. It is suggested that the chondrocytes synthesize matrix appropriate to the layer in which they lie.

Autoradiography↗
PubMed1974

Pain threshold analysis in patients with osteoarthrosis of hip.

The pain threshold was measured in patients with osteoarthrosis of the hip. The pain threshold was significantly lower in patients who required surgery than in controls. After successful surgery the threshold rose to normal levels. In patients with few or no symptoms from their osteoarthritic hips the pain threshold was high. Insensitivity to pain does not predispose towards osteoarthrosis of the hip. Indeed, the severity of symptoms can be directly related to an increased sensitivity to pain in osteoarthritic subjects.

Aged↗