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Biomedical subjects

M I Faktor

Publications and source records attributed to M I Faktor.

32 records · Page 2Linked to original sources
PubMed1979

[Stimulating effect of schizophrenic patients' plasma on the cellular incorportation of tryptophan in vitro].

A study of 21 schizophrenic patients and 21 normal donors in one experiment, conducted on a pool or erythrocytes in 18 chickens with the use of a double blind method, confirmed the previously obtained data of the stimulant action of plasma in schizophrenic patients on the uptake of tryptophan by chicken erythrocytes. It was demonstrated, that the plasma at the same time evokes an increase of cytoplasmatic enzymes (lactate dehydrogenase and myokynase). The authors studied the correlations between the influence of plasma on the tryptophan uptake and the release of hemoglobin from the erythrocytes and its concentration in the incubation medium. The data also demonstrate the parameters of functions describing the first correlation and that it has a nonmonotonous character. The problem of the connection between the plasma action on the tryptophane uptake and its hemolytic activing is discussed.

Adenylate Kinase↗
PubMed1978

[Role of serum factors in decreasing the reaction of peripheral blood lymphocytes in schizophrenia to PHA stimulation].

The blood serum of schizophrenic patients and three of its studied fractions (gamma-globulins and remaining after elimination of gamma-globulins and ultrafiltrate protein fractions) inhibit the lymphocyte response of normals to PHA stimulation (an increase of the DNA content in cells). An insignificant inhibitor effect in the blood serum of normals was seen only in the protein fraction. The PHA precipitating activity of the blood serum in schizophrenic patients which is mainly connected with its protein fraction is increased by 30%. However, there are no correlations between this blood serum activity and its capability to inhibit the response of lymphocytes to PHA stimulation.

Cells, Cultured↗
PubMed1977

[Role of genetic factors in increasing the serum lactate dehydrogenase activity of schizophrenic patients].

To elucidate the role of genetic factors in the increase of the blood serum LDH activity in schizophrenics', there have been studied 103 patients, 97 first degree nonpsychotic relatives, 58 healthy people and 32 pairs of likesex MZ and DZ twins (schizophrenics and normals). A correlation between the enzyme activity in the probands and their relatives is marked. With the aid of a quantitative estimation of the degree of genetic determination of the studied characteristic and special and twin methods the authors obtained the results fitting the hypothesis of additive polygenic inheritance with threshold manifestation.

Diseases in Twins↗
PubMed1976

[Structural changes in nucleoprotein systems under the influence of serum from ill and healthy subjects].

A thermomechanical method was applied to the study of the interaction of the model desoxyribonucleoprotein systems (DNP-systems) of chromatin with the blood sera of healthy and sick persons. It was demonstrated that the blood sera of healthy persons caused decondensation of the DNP-systems. The intensity of this action varied when the sera with the composition altered as a result of pathology were used: the sera of the patients suffering from systemic lupus erythematosus increased the condensation; in comparison with the sera of healthy persons, the sera of schizophrenic patients intensified the DNP-system decondensation. The sera action was not connected with the activity of the serum enzymes. The role played by the serum components in regulation of the structural-functional chromatin properties is discussed.

Chromatin↗
PubMed1976

[Neurotropic activity of the gamma-globulin fraction in the serum of schizophrenic patients].

The report is concerned with the influence of the blood sera of schizophrenic patients on the electric activity of neurons in snails and its 3 fractions containing respectively nonprotein compounds, gamma-globulins and the remaining proteins. It was established that the amount of neurotropic activity only of gamma-globulin fractions do not differ significantly from the respective figures of the blood sera of schizophrenic patients. In this connection the authors come to the conclusion of a possible immune nature of the neurotropic factor in the blood sera of schizophrenic patients.

Action Potentials↗
PubMed1975

[Several aspects of the study of human embryo brains].

Using the Coons direct and indirect fluorescent antibody method, cryostatic sections and cultured neuroblasts of embryonic human brain were examined for the presence of intracellular antigens. The embryonic brain tissue was obtained from mentally healthy and schizophrenic women undergoing medically indicated, induced abortion during the first four months of pregnancy. As early as four weeks after the onset of embryonal development, positive cytoplasmatic and nuclear fluorescence were seen, with one exception, after incubation with gamma -- chain specific, anti-human IgG, and antirabbit immune globulin serum. More rarely, positive fluorescence was seen following incubation with alpha-chain specific anti-human IgA. Tests with anti-human IgM were persistently negative. The serum of two acutely ill, schizophrenic women contained a factor which --a) could easily be related to the cytoplasm of embryonic brain cells; b) could be absorbed out with whole thymocytes obtained post mortem from human newborn and c) produced positive cellular fluorescence when incubated with chain-specific antihuman IgG and IgA.

Antigens↗
PubMedDate not supplied

[Decrease in the platelet level of 43 kDa immunoreactive fraction of serotonin transporting protein correlates with depressive symptoms in patients with somatoform disorders].

To elucidate the role of serotonin transporter (SERT) protein as a candidate target for somatoform disorders (SD), we have performed an association study of the SERT immunoreactive (IR-SERT) protein level by using site-specific antibodies directed at C-terminus epitope poorly conserved among other cotransporters. 22 patients who met DSM-IY criteria for SD and 32 healthy volunteers matched in sex and age participated in the study. In platelets from all healthy donors, IR-SERT proteins migrates as a diffuse band between 75 and 102 kDa and a major sharper band at 43 kDa. We revealed almost complete disappearance of platelet 43 kDa IR-SERT protein in all patients with SD. All patients were rated with Hamilton Depressive Rating Scale (HDRS). There were found a significant negative correlation between residual IR-SERT 43 kDa protein level and HDRS Scores [r = -0.83; P < 0.000001]. These findings suggest that a biosynthetic or processing abnormality may exist in SERTs in the affected population and may reflect the dysfunction of serotonin neurotransmission in CNS.

Adult↗