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M I Davydov

Publications and source records attributed to M I Davydov.

At least 19 recordsLinked to original sources
PubMed2002

[Cancer of the proximal section of the stomach: the standards of surgical treatment based on 30 years of experience].

Cancer of the GE-junction is a highly malignant tumor with early lymphatic metastasis to the lymph nodes both in the abdomen and mediastenum. At surgery, lymph nodal metastasis is revealed in nearly 80% of cases. At present, surgical treatment with extended lymph node dissection is the "golden standard". Over 30-year experience in surgically treating GE-junction tumors in 1209 patients at the Thoracoabdominal Department, Russian Cancer Research Center, Russian Academy of Medical Sciences, support the view that extended procedures are superior to standard procedures. Radical procedures were made in 956 of the 1209 patients. These included subtotal proximal gastrectomies in 54.2% of cases, transpleural gastrectomies with esophageal resection in 42.4%, and Ivor-Lewis type procedures in 3.4%. In cases with extended lymph nodal dissection, five-year survival was superior to the results of standard procedures: 32.8 +/- 6.0 and 22.6 +/- 2.8%, respectively (t = 1.8). These figures obviously testify that extended and combined procedures with extended lymph nodal dissection make it possible to stage of a primary tumor and to improve long-term survival.

Digestive System Surgical Procedures↗
PubMed2002

[The experience in the use of DNA flow cytometry to predict the natural history of malignant neoplasms].

The aim is to study the pattern of a cell population (ploidy) and to evaluate the latter's significance in the prognosis of different carcinomas. A total of 467 patients with primary carcinomas of the breast (n = 177), lung (n = 88), head and neck (n = 140), and colon and rectum (n = 62) were examined. All the patients underwent surgery alone or in combination with radiotherapy (X-ray)/chemotherapy. A follow-up lasted 6 to 120 months. DNA was measured in the operative tumor tissue specimens by using an ICP-22 flow cytometer. Diploid and aneuploid cancers occurred in 20.4-53.6 and 43.6-79.6% of cases, respectively. The frequency of recurrences was mainly associated with aneuploidy and it was more than thrice higher than that with diploidy (21.0-43.2 versus 4.5-14.4%). Five-year survival was twice worse in patients with aneuploid tumors than in those with diploid ones. The survival rates after one operation, preoperative, and postoperative radiation therapy was greater in patients with diploid tumors than in patients with aneuploid ones. Thus, DNA-ploidy of the study neoplasms is of high informative value in predicting the course of a tumorous process and in choosing treatment policy on an individual basis.

Disease Progression↗
PubMed2002

[Formalized method of deciding on treatment options in clinical oncology].

A method of constructing a "tree of problem solving" is suggested to work out viable and economical strategies of clinical therapy of tumors. The algorithm is illustrated by solving a hypothetical problem. A clinico-economic index is used to compare different modalities of tumor therapy, its lowest value representing the best regimen.

Algorithms↗
PubMed2001

Simultaneous operations in thoraco-abdominal clinical oncology.

OBJECTIVE: To increase radical operability of cases with synchronous multiple primary malignant tumours (SMPTM) of the thorax and abdomen, and of cancer patients with concomitant severe heart disease simultaneous operations are implemented in the clinical practice. METHODS: Twenty-seven simultaneous operations for SMPMT (17) and for cancers of different sites and concomitant cardiac disease (10) were performed at the Surgical Department of Thoraco-Abdominal Oncology, N.N. Blokhin Memorial Cancer Research Centre. All SMPMT cases had lung cancer. The second tumours were gastric cancer (6), oesophageal cancer (7), laryngeal cancer (3) and opposite lung cancer (1). Coronary artery bypass grafting for ischaemic heart disease was made in nine cases simultaneously with lung resection (4), tracheal resection (1), resection of the stomach or gastrectomy (4). Mitral valve commissurotomy and left pneumonectomy for lung cancer was made in one case. RESULTS: Two patients died from therapeutic complications early postoperatively. Median survival after simultaneous operations for SMPMT was 26 months. One patient undergoing simultaneous operation for cardiac disease and lung cancer died from cancer progression at 1 year following surgery. The remaining patients were followed up for 2 years free from evidence of cancer or heart disease. CONCLUSION: Simultaneous operations increase resectability, radicality and functional operability and therefore promise improvement of follow-up results in the most serious category of cancer patients in question.

Abdominal Neoplasms↗
PubMed2001

Renal angiomyolipoma extending into the right atrium.

Renal angiomyolipomas (AMLs) are benign renal tumors that may possess the features of a malignant neoplasm, such as local and vascular invasion. We describe the diagnosis and management of a rare case of AML associated with tumor thrombus extending into the right atrium.

Angiomyolipoma↗
PubMed2001

[Modern strategies on oncologic surgery].

The main modality of treatment of solid tumors, surgery is a basic component of treatment of most solid tumors. Despite the wide introduction of new drugs into oncological care and improvement of highly effective drug treatments, surgery still remains the "golden standard" in treating the vast majority of solid tumors. Oncosurgery as an area of surgical science greatly differs from general surgery as it defines a procedure not as local resection of a primary tumor, but as ablastic mobilization of the tumor with the regional lymphatics en block. In addition to improvement of intervention radicalism, expansion of a scope of dissection of lymphatic return tract makes it possible to make an adequate staging of the true spread of a tumor and to make its prognosis.

Humans↗
PubMed2001

[Statistics of lung, stomach and esophageal cancer: status of oncological care, morbidity and mortality].

Lung cancer is the most common pattern of malignant neoplasms in males, gastric cancer ranks next. In the female pattern of cancer morbidity, gastric cancer is third in the incidence of tumors, pulmonary cancer occupies the 9th place. Esophageal cancer accounts for 3%. In the mortality pattern, lung cancer holds the lead in males and ranks 4th in females, gastric cancer is second in both sexes, esophageal cancer occupies the 7th place in males. In 1999 the standardized incidence rates of cancer of the lung were 64.8 and 6.8 in males and females, respectively. Those of the stomach and esophagus were 33.6 and 7.2 in males and 6.8 and 1.2 in females, respectively. There were tendencies for decreases in the morbidity and mortality of cancer at these sites in 1990 to 1999. The morphological verification of diagnosis of lung cancer does not reached 50%, this is higher for cancer of the stomach (71.6%) and esophagus (67.7%). There has been an increase in the proportion of patients with Stage IV disease in all tumor forms in question. The basic treatment for cancer of the stomach and lung was surgical (82.2 and 38.6%, respectively) and that for esophageal cancer is radiation (47.6%). As little as 10% of patients with gastric and lung cancer survive over 5 years. In esophageal cancer, this figure is much less (5%).

Esophageal Neoplasms↗
PubMed2001

[DNA flow cytometry in the prognostication of certain malignant neoformations].

The study has been concerned with DNA ploidy and its significance for prognosis of different neoplasms. The investigation included 314 patients: primary cancer of the lung (96), head and neck (146) and large bowel (72). Patients received surgery alone or surgery plus either radiotherapy or chemotherapy; they were followed up for 6-20 months. DNA levels were assayed in resected material using an ICP-22 flow cytometer. Diploid and aneuploid cancers were detected in 20.4-53.6 and 43.6-79.6%, respectively. The recurrence rates in cases of aneuploid cancers were more than 3 times those of diploidy (21.0-43.2 and 4.5-14.5%, respectively). Overall 5-year survival in diploid patients was twice that in aneuploid ones. Similarly, survival after surgery alone, preoperative chemotherapy and postoperative radiotherapy among diploid patients was longer than in aneuploid ones. Hence, DNA ploidy examination of tumors is of great informative value in prognosing tumor process and working out individually-tailored approach to treatment.

Adenocarcinoma↗
PubMed2000

[Molecular biological and clinical-morphological studies of gastric tumors associated with Epstein-Barr virus].

The paper presents the results of the studies of gastric cancer (GC) associated with Epstein-Barr virus (EBV) among the patients residing in 4 geographical regions. In situ hybridization (ISH) techniques revealed that 49(11.4%) of the 430 examinees were EBV positive (EBV+), the virus-specific marker mRNA-1 of EBV, EBER-1) was found to be present in 80-100) of tumor cells. The proportion of EBV(+)-associated GC cases in different geographic regions ranged from 7.3 to 15%. These tumors were predominant in males (15%) as opposite to females (5.5%). Histological types most common among EBV+ tumors and their location in the stomach are also described. Serological findings indicated that the increased anti-EDV antibody response in 70% of GC cases coincided with the presence of the viral genetic information detected by ISH. In contrast to a humoral response to EBV, a humoral response to Helicobacter pylori was equal both in patients with EBV(+)- and EBV(-)-associated gastric tumors. Further molecular biological analysis of EBV isolates from virus positive and virus negative GC may answer the question whether there are really the so-called tumor and non-tumor variants of EBV.

Adenocarcinoma↗
PubMed1999

[Detection and characterization of gastric carcinoma associated with epstein-barr herpes virus].

The present investigation was carried out to estimate the incidence of Epstein-Barr virus (EBV)-associated cases among gastric carcinoma (GC) patients in Russia. Carcinoma specimens from 184 patients with GC treated at the Cancer Research Center were investigated by EBV encoded RNA-1 (EBER-1) in situ hybridization. Seventeen (9.24%) cases showed uniform EBER-1 expression restricted to the carcinoma cells. Hybridized signals were not detected in the non-neoplastic gastric epithelium. EBV involvement was significantly more frequent among males, especially in the tumors belonging to less differentiated types (moderately differentiated tubular adenocarcinomas and poorly differentiated solid adenocarcinomas) and located in the upper stomach (cardia and middle part). Most EBV-positive GCs were characterized by great lymphoid compartment involvement. The findings of the distribution of EBV-positive. GCs by sex, site, and histology are similar to those in Japan; however, the detection rate of EBV-positive cases in Russia is higher than that in Japan (6.7%) and lower than that in the USA (16%).

Adenocarcinoma↗
PubMed1998

[Main trends in the improvement of surgical treatment results in stomach cancer].

According to the data on the treatment of 964 patients with cardioesophageal cancer, the local recurrence incidence fell dramatically (from 19.7 to 4.8%) in patients who had gone extensive surgery. The results of treatment of 1,209 cases operated on for tumor in the proximal part of the stomach are discussed. Extensive excision of lymph nodes without postoperative complications was found to assure better end results. Excision of lymph nodes should be regarded as an indispensable component of extensive surgery given for stomach cancer.

Aged↗