Fungemia in neonates: report of 80 cases from seven University hospitals.
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Biomedical subjects
Publications and source records attributed to M Huttová.
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To obtain a rather complex picture on fat metabolism in newborns, fundamental characteristics of this metabolism as well as the carnitine level in their blood was correlated with corresponding values from cord blood, maternal blood and milk. The concentrations of cholesterol (CHOL), triglycerides (TGL) and apolipoprotein B (Apo-B) in 4 days old infants were higher than in cord blood (P < 0.01 and P < 0.001, resp.), but were only 50% of those in blood of the respective mothers. No differences in HDL-CHOL were observed, whereas the level of apolipoprotein A (Apo-A) in cord blood exceeded that in newborn blood (P < 0.05). The level of carnitine in milk was about twice as high as in maternal blood (P < 0.001) which was the consequence of the high acylcarnitine content in milk. Our results represent a basis for comparison of normal and pathologically altered metabolic situation, e.g. in hypotrophic newborns and potentially in newborns in need of parenteral nutrition.
The effects of exchange transfusion on plasma T4 and TSH were studied in two groups of premature newborns to evaluate the effect of maturation on the reactivity of the pituitary-thyroid axis. In newborns with a birth weight between 1900-2500 g (gestational age 35.4 +/- 0.45 weeks) the responses of both hormones were essentially similar to those reported previously for mature newborns (a profound decrease during the procedure and an increase 24 h later). In a group of newborns with a birth weight below 1900 g (average 1673 +/- 55, gestational age 32.7 +/- 0.72 weeks), however, the secondary increase in plasma T4 at 24 h after the procedure was absent. At this time both T4 and TSH levels were significantly lower than in those in heavier newborns. It is concluded that the ability to respond to exchange transfusion by an increase in plasma thyroxine at 24 h after the procedure matures at the gestational age between 32 and 35 weeks.
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