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Biomedical subjects

M Huntrakoon

Publications and source records attributed to M Huntrakoon.

43 records · Page 3Linked to original sources
PubMed1983

Computed tomography of renal oncocytoma.

Renal oncocytoma is a relatively rare tumor that has an excellent prognosis and usually may be treated adequately by local resection. Preoperative differentiation from renal cell carcinoma, which requires radical nephrectomy, is thus of importance. The computed tomographic (CT) and pathologic features of three incidentally-detected renal oncocytomas were compared with those of six renal cell carcinomas of comparable size. Renal cell carcinoma appears on CT as a solid mass that generally has an indistinct interface with normal renal parenchyma, a lobulated contour, and a nonhomogeneous pattern of contrast enhancement. These features correlate with the pathologic findings of an irregular tumor margin and the frequent presence of tumor hemorrhage and necrosis. Oncocytoma, on the other hand, generally has a distinct margin, a smooth contour, and a homogeneous appearance on contrast-enhanced CT scans. These findings correlate with a smooth tumor margin and absence of tumor hemorrhage and necrosis on pathologic examination. These features are not pathognomonic of oncocytoma, as angiographic evidence suggests that renal cell carcinoma may show both distinct margination and a homogeneous blush in 6% of cases. However, their demonstration by CT should alert radiologists and surgeons to the possibility that a renal mass may be an oncocytoma. Such a presumptive diagnosis then can lead to a surgical approach that allows for renal-conserving surgery.

Adenocarcinoma↗
PubMed1981

A scanning and transmission electron microscopic study on an unusual pelvic tumor a case report.

A portion of a pelvic mass removed from a 38-year-old female, read out on frozen section as a papillary carcinoma with psammoma bodies, was submitted to the EM lab for routine processing. Transmission electron microscopy reveals the tumor mass to be composed of cuboidal and columnar epithelial cells with short apical microvilli and numerous sites of cellular attachments. That portion of the tumor processed for scanning electron microscopy, showed cells similar to those described above but an additional cell line containing numerous cilia were found scattered randomly throughout the entire sample. This finding prompted additional study of the original light and transmission samples to determine the nature of this neoplasm. Gross, microscopic, transmission and scanning micrographs will be presented to illustrate the merits of using multiple microscopic capabilities in the differential diagnosis of unusual tumors.

Adult↗
PubMedDate not supplied

Unilateral renal cystic disease: CT findings.

Unilateral renal cystic disease (URCD) is characterized by replacement of most of one kidney by multiple cysts scattered diffusely throughout the parenchyma without the formation of a distinct, encapsulated renal mass. There are no cysts in the opposite kidney or liver. The condition is nonfamilial and does not cause renal functional impairment. We describe the clinical and radiologic findings in two patients with URCD and discuss how the disorder usually can be distinguished from other renal cystic diseases using CT. Absence of a family history of renal cystic disease and the normality of the other kidney help distinguish URCD from autosomal dominant polycystic kidney disease. The diffuse nature of the cysts in URCD and the absence of a distinct encapsulated renal mass help distinguish URCD from cystic renal neoplasms.

Adolescent↗
PubMedDate not supplied

Clear cell sarcoma of tendons and aponeuroses: histogenesis and mode of treatment.

Clear cell sarcoma of tendons and aponeuroses is a rare, slow-growing malignant tumor arising from the tendons and aponeuroses of the lower extremity, more often in the foot. Although it appears to be a benign tumor, the clear cell sarcoma can be a malignant sarcoma capable of local recurrences or distant metastases. Microscopically, there is a rather distinctive picture characterized by discrete nests and fascicles composed of spindle cells, and a small round-to-ovoid nucleus containing a central prominent basophilic nucleolus. Since there is some controversy over the best way to treat this disease, and since its histogenesis is still unknown, the authors elected to report the case of a 28-year-old white male for three reasons: first, to illustrate that the tumor is of neural crest derivation; second, to show that an ultrastructural evaluation of the tumor is imperative in some cases; and lastly, to suggest that amputation is the treatment of choice in localized disease.

Adult↗