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Biomedical subjects

M Hume

Publications and source records attributed to M Hume.

14 recordsLinked to original sources
PubMed1992

Embedded ring injuries.

Two patients, each with a history of mental illness, were assessed for embedded rings. Removal of the ring was accomplished without loss of digit or further loss of function in one patient. The other patient refused treatment. Altered mental status is a common finding in patients with embedded ring injuries.

Adult↗
PubMed1978

Venous thrombosis: mechanisms and treatment.

The role of Virchow's triad in the etiology and treatment of venous thrombosis, the natural history of postoperative thrombosis, and methods for monitoring venous embolism are described. In patients with hip joint replacements the effects of several drugs or drug combinations or placebos on wound hematoma and the effects of age, obesity, and activity and several drug combinations on venous embolism are reported.

Aging↗
PubMed1978

Hemostatic effects of uniform, low-dose subcutaneous heparin in surgical patients.

Two hours before surgery and every 12 hours thereafter 5,000 units of heparin sodium was administered subcutaneously to 100 general surgical patients. Hemostasis was evaluated by a template bleeding time and an activated partial thromboplastin time (PTT). The latter was sensitive to 0.05 units/ml of heparin and gave a straight-line response up to 0.2 units/ml. In the great majority of patients, only a modest elevation of the PTT occurred two and four hours after heparin therapy. However, in 10% to 15% the PTT was prolonged two times or more and in a similar number, PTT after surgery was shorter than baseline values despite heparin. No correlation between PTT prolongation and weight, ponderal index, age, or sex was found. Significant bleeding occurrred in three patients, two from the group of hyperresponders to heparin. Recent aspirin ingestion was implicated in one patient and our evidence indicates that low-dose heparin potentiates aspirin-induced prolongation of bleeding time in certain individuals. Local hematoma formation and discomfort from the injections was not a problem.

Adult↗
PubMed1977

Prevention of postoperative thrombosis by aspirin.

In a random double-blind trial monitored by 125I-fibrinogen leg scan, impedance plethysmography, and contrast phleobograms if impedance became abnormal, hydroxycholoroquine was shown to be no more effective than placebo for prevention of venous thrombosis after total hip replacement. Subsequently, the combination of hydroxychloroquine with aspirin was shown to be not significantly better than aspirin alone. Although the two parts of the trial were performed in an identical manner, comparison of the two sequential parts of this investigation, which provided a significant tread favoring aspirin, must be interpreted with caution. Further study including concurrent controls is needed.

Aspirin↗
PubMed1977

Treatment of pulmonary aspergillosis with di-iodohydroxyquinoline.

Thirteen patients with a clinical diagnosis of pulmonary aspergillosis were treated with the anti-amoebic drug di-iodohydroxyquinoline, 1500-1800 mg/day orally, for 20 days. All were precipitin positive before treatment and all but one became negative after treatment. Sputum became negative in all of the 10 patients in whom it had been positive before treatment. Clinical improvement was marked in four patients, moderate in three, and slight in three, no change occurring in the remaining three. These results suggest that di-iodohydroxyquinoline may be of value in the treatment of pulmonary aspergillosis.

Adult↗
PubMed1977

Treatment of chronic airways obstruction with indomethacin.

The effect of indomethacin is reported in five patients with chronic asthma. There was both subjective and objective improvment and, in three of the patients, a reduction in steroid dosage. The results suggest that the drug may be of value in the treatment of this condition.

Aged↗
PubMed1976

Venous thrombosis after total hip replacement. Combined monitoring as a guide for prophylaxis and treatment.

Monitoring of 140 patients after hip-replacement arthroplasty using both impedance plethysmography and 125I fibrinogen scanning of the lower extremities showed that half had no evidence of thrombosis, one-quarter had moderate or extensive thrombosis, and one-quarter had abnormal scans only. In the patients with only abnormal scans the process appeared to resolve spontaneously. The findings by impedance plethysmography therefore appeared to differentiate non-invasively between thromboses that would and would not resolve, and it is suggested that for some patients a monitoring regimen may be preferable to routine prophylaxis.

Arthroplasty↗
PubMed1975

Extent of leg vein thrombosis determined by impedance and 125-I fibrinogen.

Modification of impedance plethysmography to include a thigh cuff improves sensitivity. Twenty-seven of thirty-two subjects (85 per cent) were correctly classified by comparison with phlebograms. Combined surveillance of patients at risk with cuff impedance plethysmography and 125I fibrinogen, carried out fifty subjects after total hip replacement demonstrated that silent venous thrombosis can be detected. Moreover, an estimate of thrombus size can be made, at least to the extent that clinically significant thrombi can be distinguished from minute thrombi.

Evaluation Studies as Topic↗