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Biomedical subjects

M Hrubisko

Publications and source records attributed to M Hrubisko.

At least 19 recordsLinked to original sources
PubMed1992

Suitability of cisplatin solutions for 14-day continuous infusion by ambulatory pump.

The stability of cisplatin (DDP) solutions (1 and 1.6 mg/ml in saline-mannitol) in plastic infusion bags was studied for up to 14 days at 25 degrees C, 37 degrees C and 60 degrees C. Small changes in the solution were observed, but no evidence of any decomposition product was seen. Some precipitation of DDP was seen in the 1.6-mg/ml solution at the lower temperatures. Fluid loss from the bags was significant at the higher temperatures.

Chromatography, High Pressure Liquid↗
PubMed1992

[Results of detection of hepatitis C virus antibodies (anti-HCV) in blood donors and selected patients].

The authors examined 509 donors for potential carriership of the virus of hepatitis C (HCV), using kits for the detection of anti-HCV. Concurrently they examined also 110 hameatological patients who had a major transfusion of blood, plasma and its derivatives. They found that in the so-called healthy population anti-HCV is present in 0.39%. In haematological patients, i.e. patients with frequent haemotherapy they detected 29 positive cases, i.e. 26.36%. The largest number of anti-HCV positive patients was in the group of haemocoagulopathies. The investigation confirmed the close association between haemotherapy and the transmission of HCV. The authors draw attention to the need to introduce anti-HCV examinations in the transfusion service as an important preventive provision.

Blood Donors↗
PubMed1978

[The recessive Hm phenotypes].

The survival of "Bombay" erythrocytes as well as that of "para Bombay" red cells (first and third class according to Race and Sanger classification) has been studied among non compatible and "para Bombay" individuals. This shows not only the heterogeneity of these phenotypes (as already described by Salmon and co workers) but also the presence of highly differenciated ABH formed antigens. H deficient recessive phenotypes are not explained by the presence of an amorphe h gene. They arise from the activity (or better from the non activity) of the regulation genes of which the recessive alleles x and z in double dose do not enable a normal functioning of the H gene. The appelation Hxx for "Bombay" phenotypes (1st classe) and the appelation Hzz for Hm recessive (3d. class) phenotypes are proposed. Genetics as well as the synthesis of Ah, Bh (AHm, BHm) phenotypes have not yet been clarified. Interaction of zz and sese genes, or accomplementation in the "trans" position have to be looked at.

ABO Blood-Group System↗