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Biomedical subjects

M Horie

Publications and source records attributed to M Horie.

At least 199 records · Page 11Linked to original sources
PubMed1986

[A case of male duplicated urethra in recurrent urinary tract infection].

A dorsal incomplete duplicated urethra was found in a 13-year-old male, who had noticed occasional urinary incontinence and recurrent urinary tract infection. The accessory urethra lay dorsal from the glans to bladder neck in parallel with the normal ventral urethra. The external orifice of the accessory urethra was also dorsal to the normal urethral orifice in the glans. Voiding cystourethrogram demonstrated double stream but the patient did not notice it because of pseudophimosis. Retrograde urethrogram showed the accessory urethra which arised from the dorsal surface of the prostatic urethra with a parallel normal urethra. The pendular portion of the accessory urethra was surgically removed, the glans portion of the urethra and posterior urethra were cautilized with electrocoagulation for the purpose of preservation of urinary continence. The patient was postoperatively free from urinary tract infection and urinary incontinence.

Adolescent↗
PubMed1985

Role of coronary spasm in different anginal syndromes.

Angina pectoris is a clinical syndrome caused by transient myocardial ischaemia due to an imbalance between myocardial oxygen demand and supply. It is now evident that coronary artery spasm plays an important role in the pathogenesis of various forms of angina pectoris. Angina pectoris that is mainly caused by coronary artery spasm (coronary spastic angina) has one or more of the following characteristics: 1) the attack occurs at rest, 2) the attack is associated with ST-segment elevation in the ECG, 3) the attack has a variable exercise threshold, and 4) the attack is suppressed by Ca-antagonists but not by beta-adrenergic blocking agents. On the other hand, angina pectoris that is caused by increased myocardial oxygen demand in the presence of severe and extensive organic stenosis (organic angina) has the following characteristics: 1) the attack is induced by constant amount of exertion irrespective of hour and day and is relieved by rest, 2) the attack is associated with ST-segment depression in the ECG, and 3) the attack is suppressed by beta-adrenergic blocking agents, which decrease myocardial oxygen demand.

Angina Pectoris↗
PubMed1984

Revised method for the quantitative determination of 5-hydroxytryptamine in human plasma by gas chromatography--mass spectrometry--selected ion monitoring.

To estimate the 5-hydroxytryptamine level in human plasma by gas chromatography--mass spectrometry--selected ion monitoring (GC--MS--SIM), a recovery method from plasma and derivatization conditions with pentafluoropropionic anhydride were investigated. By heating 5-hydroxytryptamine at 140 degrees C for 4 h in the presence of pentafluoropropionic anhydride the peak intensity of derivatized 5-hydroxytryptamine increased more than three times in comparison with the reported method. There was a marked difference in the plasma levels of 5-hydroxytryptamine obtained using the GC--MS--SIM method compared to those obtained using fluorometric assay.

Carbon Radioisotopes↗
PubMed1984

Variant angina induced by alcohol ingestion.

We gave alcohol to 15 patients with variant angina to induce the attacks at the hospital. Anginal attacks were repeatedly induced in seven of them. Although the time lag between alcohol ingestion and the attacks varied widely among patients, from 1.5 to 12 hours, it was fairly constant in each patient. We carefully examined the histories of 101 patients with variant angina to become familiar with the relationship between alcohol ingestion and the attacks of angina. Seventy-one patients took alcohol in their daily lives. Nineteen of the 71 patients (26.8%) who took alcohol had a definite relationship between alcohol ingestion and the attacks. We conclude that alcohol induces anginal attacks or coronary artery spasm in not a small number of patients with variant angina.

Aged↗
PubMed1984

The effects of reperfusion of infarct-related coronary artery on serum creatine phosphokinase and left ventricular function.

In 31 patients with transmural myocardial infarction in whom coronary arteriography was performed within 8 hours after the onset of symptoms, we examined (1) the effect of restoration of coronary blood flow on serum CPK time-activity curve and (2) the relationship between cumulative CPKr and the left ventricular function in the chronic phase. We divided 31 patients into 2 groups: Group A consists of 19 patients in whom coronary reperfusion was established. Group B consists of 12 patients whose coronary artery remained occluded. In group A, the time required to reach peak serum CPK activity was significantly shorter than in group B. When comparing CPKr with percent abnormally contracting segment (%ACS) in 2 groups, correlation between CPKr and %ACS was not good, but it revealed linear relation in both group A and B. CPKr divided by %ACS (CPKr/%ACS) was significantly higher in group A than in group B. We conclude that reperfusion of infarct-related coronary artery changes serum CPK time-activity curve resulting in earlier appearance of peak serum CPK and that infarct size cannot be estimated by serum CPK level alone.

Adult↗
PubMed1984

Disposition of suprofen in rats following intravenous injection.

Distribution and excretion of DL-2-(4-(2-thienylcarbonyl)phenyl)propionic acid (suprofen) were evaluated in male and female rats following intravenous (i.v.) injection of labeled suprofen. The radiometric findings following i.v. administration of 2 mg/kg of 3H-suprofen to male and female rats showed similar patterns of blood level and excretion of the radioactivity. Elimination of 3H-suprofen from the blood was rapid; most of the radioactivity was excreted in the urine and a portion in the feces within 24 h after injection. After rats with biliary fistulas were given an i.v. dose of 2 mg/kg of 3H-suprofen, approximately half of the dose was excreted in the bile during 48 h. The only tissues with concentrations higher than that in the plasma were those involved in metabolism and excretion (liver and kidney); other tissue levels were all very low and there was no evidence of accumulation of drug-related material in any tissue.

Animals↗
PubMed1984

Autoradiographic study on the distribution of suprofen in rats of both sexes.

The tissue distribution of 14C-labeled DL-2-(4-(2-thienylcarbonyl) phenyl) propionic acid (suprofen) after po administration was studied in male, female, and pregnant rats by whole-body autoradiography. 14C localized rapidly in such highly vascularized tissues as liver, kidney, and lung as well as heart in rats of both sexes, but no significant uptake was found in the central nervous system. About half of the 14C in the liver and kidney was found to be unchanged suprofen; smaller amounts of 2-(4-(2-thienylhydroxymethyl)phenyl)propionic acid and 2-(4-carboxyphenyl)propionic acid were also detected. In pregnant rats, a low level was found in the uterus and placenta; the drug penetrated the fetuses to only a limited degree. No appreciable radioactivity was found in rat tissues 24 h after dosing.

Administration, Oral↗
PubMed1984

[Chemotherapy of urothelial cancer with vincristine, mitomycin C, bleomycin, tegafur and OK-432].

A total of 24 patients with urothelial cancer were treated with a combination chemotherapy consisting of vincristine (1 mg, i.v., day 1), bleomycin (15 mg, or peplomycin, 10 mg, i.m. day 2), mitomycin-C (4 mg, i.v. day 3), tegafur (600-750 mg, p.o., every day) and OK-432 (2-4 KE, i.m., day 1, 3, 5). This one-week course was repeated for an average of 4.6 courses. Of these cases, 13 patients with early stage treated as adjuvant chemotherapy after radical operation showed strong suppressive effects against tumor recurrence or metastasis except 3 cases. However, in advanced cancer this regimen was less effective. Therefore, we modified this regimen: VCR 2mg and PEP, 10 mg on days 2, 4 and 6. This modified regimen was given to two patients and one showed partial response and I-A according to Karnofsky's criteria. Mild side effects such as slight leukopenia, fever up, gastrointestinal symptoms or alopecia were observed. These results suggest that this regimen could be used as an adjuvant chemotherapy after radical operation of urothelial malignancy for the purpose of protecting tumor recurrence or metastasis.

Aged↗
PubMed1984

[Treatment of complicated urinary tract infections caused by fungi].

The predisposing factors of funguria and the clinical efficacy of treatment with ketoconazole, a new oral imidazole antifungal drug were studied in 10 patients with complicated urinary tract infection due to fungi. Preceding antibiotic therapy, presence of indwelling catheter and malignant tumor were regarded as the important factors that predisposed to the fungal urinary tract infections. Patients received 200 mg of ketoconazole once a day for 5 to 14 days. Of the 9 patients in whom clinical efficacy of ketoconazole was evaluated, excellent response was obtained in 4 patients, moderate in 2 and poor in 3 patients. Of the 9 strains of fungi isolated before treatment, 6 strains or 67% were eradicated after treatment. Neither subjective nor objective side effects were observed in any of 10 patients receiving ketoconazole, and laboratory tests showed elevated BUN and serum creatinine in 1 patient. From the results obtained in this study, ketoconazole was regarded as useful in the treatment of complicated urinary tract infection due to fungi.

Administration, Oral↗
PubMed1983

Coronary arteriographic findings during early hours of acute myocardial infarction: response to intracoronary injection of nitrates.

We performed coronary arteriography and gave intracoronary injection of nitrates within 8 hours after the onset of symptoms of acute myocardial infarction in eighteen patients. Improved distal filling or patency of the total occluded coronary artery after intracoronary injection of nitrates occurred in 4 of 18 patients. In one of four patients the first intracoronary nitrates injection failed to release the initial total occlusion, but after intracoronary Urokinase administration, the second nitrates injection succeeded to dilate the completely occluded coronary artery. Coronary arteriography was again performed in sixteen patients in the chronic stage (4-15 weeks after the onset of acute myocardial infarction) and ergonovine maleate was injected intravenously in seven patients. Focal spasm was induced by ergonovine injection in three patients in one of whom intracoronary nitrates failed to release the complete obstruction in the acute stage. We conclude that coronary spasm as well as intracoronary thrombosis plays an important role in the production of acute myocardial infarction.

Adult↗
PubMed1981

Studies on drug metabolism by use of isotopes XXVI: Determination of urinary metabolites of rutin in humans.

Determination of urinary metabolites of orally administered rutin and rutin-2',5',6'-d3 in humans was carried out by TLC and GLC-mass spectrometry. In human urine, 3-hydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic acid, 3,4-dihydroxytoluene, and beta-m-hydroxyphenylhydracrylic acid were identified as rutin metabolites. Unchanged rutin and quercetin were not present in urine.

Biotransformation↗
PubMed1981

Comparison of coronary arteriographic findings during angina pectoris associated with S-T elevation or depression.

Coronary arteriographic findings during an attack of angina pectoris associated with S-T segment elevation and angina associated with S-T depression were compared in 54 patients. Thirty-eight attacks with S-T segment elevation included 2 that were spontaneous, 6 induced by methacholine, 4 by epinephrine with or without propranolol, 9 by arm exercise, 5 by hyperventilation with or without Tris-buffer infusion and 12 by ergonovine maleate. Twenty-nine of the 38 attacks were associated with total occlusion, 8 with subtotal occlusion and 1 with diffuse narrowing of a major coronary artery caused by spasm. Twenty-six attacks with S-T segment depression included 3 induced by methacholine, 13 by arm exercise, 3 by hyperventilation with or without Tris-buffer infusion and 7 by ergonovine maleate. Eight of the 26 attacks were associated with subtotal occlusion and 9 with diffuse narrowing of a major coronary artery caused by spasm; 3 attacks were associated with total occlusion of a major coronary artery well supplied with collateral vessels and 2 with total occlusion of a small coronary branch caused by spasm. Four attacks were associated not with spasm but with fixed subtotal occlusion of a major coronary artery (3 attacks) or total occlusion of a major coronary artery receiving collateral vessels (1 attack). Only 2 of the 31 patients with S-T segment elevation had collateral vessels compared with 8 of the 16 patients with S-T segment depression (p less than 0.001). It is concluded that angina pectoris associated with S-T segment elevation usually indicates more severe myocardial ischemia than angina associated with S-T segment depression.

Adult↗