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Biomedical subjects

M Holzbauer

Publications and source records attributed to M Holzbauer.

At least 55 records · Page 3Linked to original sources
PubMed1973

The oestrous cycle and monoamine oxidase activity.

1. During the oestrous cycle of the rat, monoamine oxidase (MAO) activity was studied in the uterus, the ovaries and the adrenal glands and also in 4 brain regions which are rich in monoamines. In all these structures the activity was lowest during the night between oestrus and metoestrus. High values were found in di-oestrus, with the exception of the uterus in which the MAO activity reached its peak during metoestrus.2. A stimulating effect of progesterone on uterine, ovarian and adrenal MAO activity was observed.3. An index for the cyclic variations in progesterone production was obtained by measuring the adrenal and ovarian progesterone content at the same stages of the cycle as MAO activity.4. The sum of the amounts of progesterone contained in the ovaries and adrenal glands was low in early oestrus but increased during late oestrus when MAO activity was at its minimum. Progesterone contents were high in met- and di-oestrus when MAO activity was also high.

Adrenal Glands↗
PubMed1971

In vivo production of steroids with central depressant actions by the ovary of the rat.

1. In addition to progesterone and 20-dihydroprogesterone, the following unconjugated steroids were isolated from ovarian tissue and ovarian venous blood of mature, non-pregnant rats: pregnenolone, 3betaOH-5alpha-pregnan-20-one, 3alphaOH-5alpha-pregnan-20-one, 20alphaOH-5alpha-pregnan-3-one and 5alpha-pregnane-3alpha, 20alpha-diol.2. Their concentration in the ovarian tissue and their secretion rates into the ovarian venous blood was of the same order of magnitude as that of progesterone.3. In the evening of the day of pro-oestrus significant increases in the ovarian contents of the following steroids were observed: progesterone, +140%; 3alphaOH-5alpha-pregnan-20-one, +320%; 20alphaOH-5alpha-pregnan-3-one, +195%; sum of pregnenolone and 3betaOH-5alpha-pregnan-20-one, +275%.4. At the same time the ovarian progeterone secretion rate was increased by 365%, that of 3alphaOH-5alpha-pregnan-20-one by 190%.5. A possible physiological role of the ovarian allopregnane derivatives as central depressant agents is discussed.

Animals↗
PubMed1971

The contribution of the adrenal gland to the total amount of progesterone produced in the female rat.

1. The amount of progesterone contained in both adrenal glands of a rat was similar to or larger than the amount of progesterone in the ovaries of the same rat. This was found in unstressed rats, in stressed rats and also in pregnant rats.2. After ether anaesthesia and exsanguination the adrenal progesterone content was increased by 75%; the ovarian progesterone content remained unchanged.3. In contrast, prolonged operative stress resulted in a rise in the ovarian content of progesterone and 20-dihydroprogesterone whereas the adrenal progesterone content of these rats was lower than that of unstressed rats.4. The rate at which progesterone was secreted by the adrenal glands of stressed rats was similar to the ovarian progesterone secretion rate. Rats which were kept under mild stress conditions before the experiment showed higher adrenal progesterone secretion rates.

Adrenal Glands↗