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Biomedical subjects

M Holtz

Publications and source records attributed to M Holtz.

At least 55 records · Page 3Linked to original sources
PubMed1982

Utilization of a silastic sheet in tendon repair of the foot.

Specific reparative processes often dictate the function of a tendon upon completion of healing. At times the surgeon must improvise when the results of a previous traumatic or iatrogenic insult to a tendon produced a less than desirable result. The following is a case in which the authors utilized Silastic sheeting as a pseudosheath in the repair of an iatrogenic laceration of the extensor hallucis longus tendon in a previous surgery.

Adult↗
PubMed1980

[Developmental tendencies of hemadsorption in uremia treatment].

After at first having dealt with the present stage of haemoperfusion in the therapy of chronic renal insufficiency, the developmental tendencies for the haemoadsorbers to be expected are mentioned which in future allow to think of a diminution of the artificial kidney. Own results concerning the behaviour of blood compatibility and the effectivity of different active charcoals show that it is to be reckoned with the further development of unstratified adsorbents or such ones with ultra-thin layer. Comparative examinations of 4 patients from the chronic haemodialytic programme, who were treated for 4 months with the CDAK 1.8 and then for 4 months with the sorbent dialyser 1.3, could not show any essential differences in the behaviour of the low-molecular substances urea, creatinine and uric acid and of the clinical condition of the patients.

Creatinine↗
PubMed1980

[Technics and indications for hemofiltration treatment].

Technique, possibilities of application, advantages and disadvantages of haemofiltration are described. A convective mass transport underlies the method. By this means the elimination of molecules of different size takes place with the same speed and the removal of so-called middle molecules is performed more effectively than in the usual method of dialysis.

Acute Kidney Injury↗
PubMed1980

[Technic and indication for controlled ultrafiltration].

The isolated ultrafiltration with commercial dialysators gives a possibility of the massive dehydration in a short time without disturbing the well-being of the patient. If in patients undergoing a dialysis a following haemodialysis (sequential ultrafiltration haemodialysis) is necessary, particularly in patients with acute complications hypotonic circulatory conditions may develop. An infusion of a fourfold concentrated human dry plasma during the ultrafiltration may prevent these hypotensions, since reduction of osmolality and losses of circulation-effective substances are prevented during haemodialysis. With the help of this kind of treatment conditions of hyperhydration of different genesis may be removed also in patients with inclination to hypotension.

Acute Kidney Injury↗
PubMed1980

[Experimental studies of the treatment of hypotensive blood circulation disorders during sequential ultrafiltration hemodialysis].

Particularly in risk patients who in the condition of hyperhydration underwent sequential ultrafiltrations-haemodialysis treatment the decrease of blood pressure which appears in individual cases under the treatment is negatively decisive for the success in therapy. In 33 hyperhydrated patients who underwent dialysis, therefore, with the help of the fourfold concentrated human dry plasma DAB 7 the influence of a combined osmo- and substitution therapy on this circulatory complication was investigated. Under the sequential ultrafiltration by means of application of human dry plasma also at an initial decrease of blood pressure not only a stabilisation, but also an increase of blood pressure is achieved. This favourable circulatory behaviour continues also during the following haemodialysis, Apparently by the application of the human dry plasma physiological compensation mechanisms are evoked by various factors such as pharmacological effects on the excitable structures by sodium, potassium and catecholamines and physical effects on the plasma volume by increase of the osmolality and increase of the oncotic pressure. The use of human dry plasma allows the performance of an ultrafiltration treatment as well as of a haemodialysis in hyperhydrated risk patients who are in a circulatory collapse and thus considerably enlarges the area of indication of the sequential ultrafiltration dialysis treatment.

Adult↗
PubMed1980

[Hemodialysis with Bi-Flo cannulas].

It is reported on the use of the double-lumen Bi-Flo-puncture canule in chronic haemodialysis patients. In a sufficient flow through the atrioventricular fistula no significant decrease of the effect of dialysis was the result. It is recommended to render the proof of a perhaps existing shunt volume between the two lumina of the Bi-Flo-canule before the permanent use of it, in case of the existence of an only moderately functioning atrioventricular fistula.

Arteriovenous Shunt, Surgical↗
PubMed1979

[Possibilities of using hemoperfusion in the treatment of chronic kidney insufficiency].

A survey of the administration possibilities of the activated charcoal haemoperfusion in the treatment of the chronic renal insufficiency is given. Various coating methods for activated charcoal as well as important adsorption abilities of the activated charcoal for uraemia-specific metabolites are described in detail. Then comes a classification of the haemoperfusion in the treatment of ureamia. The result is that at present the use of haemoperfusion with activated charcoal in the therapy of uraemia may be regarded only as a supplementary therapy of the haemodialysis and the haemofiltration, respectively.

Adsorption↗
PubMed1979

[Serum complement and protein metabolism in chronic dialysis patients].

1. When a so-called free diet is granted there is the danger of a protein deficit, which can be proved in a significant decrease of the serum transferrin and of the complement factor E3c, in patients in the chronic haemodialysis programme. 2. Within the group undergoing dialysis a correlation analysis did not result in a statistically ascertained connection between the complement factor C3c and the total haemolytic activity and the transferrin, respectively. 3. On the basis of a diet analysis a connection between the protein supply and the serum transferrin level could be established, which was not to be proved for the complement factor C3c and the total haemolytic activity, respectively. 4. Low transferrin values in the serum seem to be followed by a deterioration of the anaemia situation of the patient undergoing haemodialysis. 5. Compared with the total haemolytic activity and the complement factor C3c the determination of the serum transferrin allows an essentially exacter information about the protein metabolism of the patient undergoing a chronic haemodialysis.

Blood Proteins↗
PubMed1979

Serum complement and protein metabolism in chronic dialysis patients.

1. Patients receiving regular hemodialysis treatment who are permitted to select their own diets are in danger of a protein deficiency manifested by a significant reduction in serum transferrin and in complement C3c. 2. Correlation analysis within the dialysis group revealed no secure connexion between the complement C3c and total hemolytic activity respectively, and transferrin levels. 3. Analysis of diets showed that protein intake and the serum transferrin level correlate. No such correlation was found for the complement C3c or total hemolytic activity. 4. Low transferrin levels in the serum appear to result in more severe anemia among dialysis patients. 5. Knowledge of the serum transferrin level permits much more exact assessment of the protein metabolism in regular hemodialysis patients than knowledge of the total hemolytic activity or the level of the complement C3c.

Blood Proteins↗
PubMed1978

[Hemodialysis and metabolic disorders].

On the basis of investigations of the water and electrolyte balance, of the protein balance, the lipid metabolism and the hormone metabolism at the instance of aldosterone a concept of specific dialysis-conditioned pathophysiological disturbances is developed in patients undergoing a chronic programma of dialysis. The changes of metabolism induced by apparative therapy have a decisive influence on the pathophysiological mechanisms in the uraemic organism and condition a specific pathophysiology of the patient undergoing dialysis.

Aldosterone↗
PubMed1978

[Osmotherapy of acute kidney failure with special reference to plasma renin activity and mineral balance].

13 dogs were used to generate an acute toxic renal failure by sublimate. The alterations both of plasma renin activity (PRA) and of the acid-base and mineral balance were observed in uremia and after "osmotherapy" with mannitol (13 dogs). In the course of toxic renal failure the PRA increases on the average. A decompensated metabolic acidosis with general transmineralization is observed. Since in the stage of anuria the Na+ in urine fails to reach the macula densa cell canicularly, the theory is advanced that only the intracellular sodium in the macula densa cell is responsible for the regulation of the position of the vas deferens. Following "osmotherapy" the PRA is significantly lowered. The acidosis is still worsened under conditions of anuria. For the regulation of renin it has to be assumed that the enzyme in acute anuria after osmotherapy is being altered especially by volume receptors. Thus, osmotic therapy seems to be reasonable only with existing residual diuresis. This is valid especially for the administration of mannitol, because this substance remains strictly outside the cell.

Acute Kidney Injury↗
PubMed1975

[Application of a mathematical model to the penetration of amino acids through a dialysis membrane in chronic hemodialysis].

With the help of a one-pool-model from the clearance values measured for 4 different dialysator models the elimination rates for amino acids are calculated with special regard to the essential amino acids. In these cases the body-weight of the patient also belongs to the calculation of the elimination of the amino acids. The loss of the amino acids under the dialysis procedes corresponding to an e-function and is particularly high during the first period of dialysis.

Amino Acids↗