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Biomedical subjects

M Hoffmann

Publications and source records attributed to M Hoffmann.

At least 217 records · Page 12Linked to original sources
PubMed1982

[Topical treatment of acne vulgaris with erythromycin and benzoylperoxide (author's transl)].

16 healthy persons were treated for 7 weeks with a 1% erythromycin containing ointment. Another 25 persons (among them 10 acne patients) were treated during the same period of time with a combination therapy consisting of erythromycin (1% in an unspecific ointment base) and benzoylperoxide (5% in a gel base). The combined therapy reduces the micrococcaceae in the pilosebaceous ducts significantly. On the other side the therapy consisting only of erythromycin causes only initially a decrease and then an increase in the number of micrococcaceae. Induction of resistance to erythromycin is in both cases considerable. In both cases a reduction of propionibacteria which are most important for the pathogenesis of acne must be assumed. Because of the probable pathogenetic role of staphylococci in acne vulgaris an additional improvement of the therapeutical results can be expected in the case of combination therapy. In vitro experiments demonstrate further that an erythromycin treatment leads to considerable resistance induction in S. aureus, regardless of whether it is applied alone or in combination with benzoyl peroxide.

Acne Vulgaris↗
PubMed1982

Assessment of psychological reactions in disaster victims.

Through the joint efforts of the area community mental health center and an emergency relief organization, psychological reactions of flood victims were measured. A random sample of 124 adults and 54 children were interviewed, using scales reflecting measures of depression and stress. Results showed that adults perceived themselves to be significantly more depressed and stressed in areas such as adaptation and physical complaints. Children's results were mixed, depending on age, although problems existed with regressive and aggressive behaviors, fears, and in miscellaneous areas such as sleep difficulty. Recommendations are made for further community mental health involvement, as well as emphasizing the need for further empirical work in the assessment of postdisaster emotional sequelae.

Adolescent↗
PubMed1982

The effect of aortic valve replacement on survival.

We retrospectively studied 252 operated and 47 unoperated patients with isolated aortic valve disease. Aortic valve replacement (AVR) was recommended to all patients based on clinical and hemodynamic data. Preoperative hemodynamic and angiographic data were similar in operated and unoperated cohorts. Seventy-one percent of patients received a Björk-Shiley prosthesis. Operative mortality was 7% for the entire surgical series. For patients with predominant aortic stenosis (AS), survival at 3 years was 87% in operated and 21% in unoperated patients (p less than 0.001). For patients with predominant aortic insufficiency (AI), the 5-year survival rate was 86% in operated and 87% in unoperated patients (NS). AVR improved long-term survival in patients with AS who had normal or impaired left ventricular (LV) function. In patients with AI and normal LV function, survival was not improved after AVR, but those with LV dysfunction who were operated on tended to survive longer (NS). Long-term survival of unoperated patients with AI was better than that in unoperated patients with AS. We conclude that AVR improves long-term survival in patients with AS who were normal or abnormal LV function, and that AVR does not change long-term survival in patients with AI, although those with LV dysfunction tended to survive longer.

Adult↗
PubMed1981

[Effects of animal age and feeding regime on the quantitative and qualitative characteristics of intensively fattened lambs. 2. Rumen volume and structure of rumen mucosa].

Lambs of the species Merino mutton sheep kept on a perforated floor received, from their 38th day of life, either fattening feed for lambs ad libitum or fattening feed for lambs ad libitum plus chopped dried green fodder ad libitum (quota 17% of the intake of dry matter). At intervals of three weeks 4 lambs of each group were slaughtered from their 40th to their 166th day of life. The determination of the physical rumen volume of one half of the animals did not show significant differences between the two feeding regimes. The rumen volume showed an approximately linear increase (B = 0,84) with the increasing age of the animals. Hyper- and parakeratotic changes of the epithelialis of the rumen were caused by both feeding regimes. They were distinctly stronger and earlier developed in animals which only received fattening feed for lambs. The measuring of the rumen villi showed significantly smaller villi in all age groups of those animals which had taken in dried lucerne green fodder as a supplement.

Age Factors↗
PubMed1981

[Activity of disaccharidases in growing sheep. 3. Fattening lambs 5 to 18 weeks of age].

Lambs at an age between 4 and 18 weeks were kept on perforated floor and received pelleted fattening feed for lambs as sole feed ad libitum. After the maltase activity in the duodenal mucosa resp. the contents of the duodenum at an age of 5 weeks was low, it amounted to 6.98 resp. 5.31 units per 0.1 g fresh weight at the end of the eighth week and in the duodenal mucosa it remained on this level to the age of 18 weeks. In the contents of the duodenum it decreased to 3.25 units in this period. The lactase activity in the duodenal mucosa resp. the contents of the duodenum decreased continuously from 30.5 resp. 25.7 to 13.6 resp. 14.8 units in the period investigated. The maltase activity in the pancreas remained constant in the period investigated (4 units per 0.1 g fresh weight). Saccharase activity could not be detected in both duodenal mucosa and contents of the duodenum.

Aging↗
PubMed1981

[Pancreatic lipase activity in growing sheep].

The development of the activity of pancreas lipase was observed at lambs reared with and without ewes from their birth to an age of four weeks and in a second series between five and 18 weeks. A statistically significant influence of the age on the level of activity of pancreas lipase could be observed. It was also influenced by the feeding regime, that is, the lambs reared without ewes which were fed restrictively with milk replacer showed a significantly higher activity of pancreas lipase on comparison with lambs reared with milk replacer ad libitum or those reared by ewes. 8-week-old lambs after a suckling period of four weeks and the subsequent sole feeding with pelleted mixed feed reached approximately the same activity of pancreas lipase as adult wethers.

Animal Feed↗
PubMed1981

[Glossitis rhombica mediana. A study of 4422 dermatologic patients].

Though known for a long time and by no means rare, median rhomboid glossitis (MRG) still gives rise to questions concerning its dignity and etiology. MRG was found in 54 out of 4,422 stomatologically investigated dermatological patients. The patient's ages ranged from 10 to 69 years, the sex ratio was 3:1 male to female. Candida albicans was found in 18 out of 22 MRG lesions examined mycologically. These findings, the constant location and the stationary course were interpreted as a secondary Candida albicans colonization on a dysembryogenetically determined locus minoris resistentiae. Dysembryogenetic, anatomic and microbial factors contribute to the etiology and pathogenesis of MRG.

Adolescent↗
PubMed1980

A new surface antigen (PC.2) expressed exclusively on plasma cells.

Somatic cell hybridization of NS.1 nonsecretor myeloma cells with spleen cells of (DBA/2 X C57BL/6)F1 mice immunized against the myeloma MOPC 70A of BALB/c mice led to the establishment of five hybridoma clones which continuously secrete anti-MOPC 70A cytotoxic antibodies. The respective antigen detected by each of the five monoclonal antibodies is expressed both on plasmacytomas and on antibody-secreting cells as the only normal cell type. The tissue distribution of this new antigen is different from that reported for the alloantigen PC.1, and we have therefore designated it as PC.2. On the basis of immune elimination of direct and indirect plaque-forming cells, all mouse strains tested express PC.2 determinants, identifying PC.2 essentially as an autoantigen. Conventional anti-PC.1 alloantiserum contains antibodies to the PC.2 determinant, and these antibodies are distinguishable from the anti-PC.1 antibodies proper by the fact that only the latter are absorbed by liver cells. Monoclonal anti-PC.2 antibodies are not directed against MuLV-(murine leukemia virus)--associated antigens as over 20 ecotropic, several MCF (mink colony forming recombinant, and xenotropic viruses failed to react in immunofluorescence assays.

Animals↗
PubMed1980

[Investigations of the activity of disaccharidases in growing sheep. 1. Suckling lambs from birth to an age of 4 weeks].

Investigations of the course disaccharidases take in duodenum and pancreas were made with 20 suckling lambs (straw litter, supplementary feed from 3rd week onwards) at an age between 1 and 30 days. In the first week of the Lambs' lives the activity of lactase in the duodenal mucosa was highest. In the following weeks there was a slightly falling tendency. During the first four weeks of the lambs' lives there were no statistically significant differences concerning the maltase activities in the duodenal mucosa. At the beginning of the first and at the end of the fourth week of the lambs' lives the activity of lactase in the content of the duodenum was significantly lower than at the end of the first and up to the third week. The maltase in the contents of the duodenum showed a significantly higher activity at the end of the fourth week of life. Enzyme activities in the contents of the duodenum were significantly lower then those in the mucosa. After maltase activity in the pancreas had shown high values in the first two days of life, it decreased distinctly toward the end of the first week and than increased again up to the fourth week of life. In the period investigated, saccharase activity in the duodenal mucosa and in the contents of the duodenum could not be detected in any lamb.

Animals↗
PubMed1980

[Studies of the activity of disaccharides in growing sheep. 2. The influence of the feeding regime on the activity of disaccharidases in lambs up to the age of 4 weeks under various rearing conditions].

In two groups of 16 animals each lambs were fed restrictively resp. ad libitum withour ewes with a milk replacer up to the age of four weeks. Maltase activity in the contents of the duodenum and the pancreas homogenate increased with the increasing age of the lambs. The maltase activity of the restrictively fed lambs was higher. The maltase activity in the duodenal mucosa was not influenced by the age. Lactase activity in the duodenal mucosa showed a decreasing tendency up to the end of the four week of life; an increase of lactase activity in the contents of the duodenum could be ascertained up to the fourth week. In comparison with the suckling lambs reared by ewes (cf. 1.) the maltase activity in the duodenal mucosa of the lambs reared without ewes was lower and that in the contents of the duodenum was higher. Concerning lactase activity, there were not significant differences between the rearing and feeding regimens up to the age of three weeks. At the end of their fourth week of life the lactase activity in the suckling lambs was significantly lower than that in the lambs reared without ewes. The total maltase activity (= sum of the activities in the duodenal mucosa, the contents of the duodenum and in the pancreas) showed the highest values for the lambs reared without ewes and fed restrictively in the first three weeks of life. Saccharase activities in the duodenal mucosa or the contents of the duodenum could not be detected in any case.

Animals↗
PubMed1979

[Possibilities of prediction the digestibility of crude nutrients by fullgrown and growing sheep from the crude nutrient content of the rations. 2. Rations with a higher content of crude fibers (mixtures of straw and concentrated feed as sole feed].

Eight variants of recipes for mixtures of straw and concentrated feed with 10 to 60 per cent straw more or less finely ground (86 to 314 g crude fibre per kg dry matter) and fattening feed for lambs (50 g crude fibre per kg dry matter) were checked concerning the digestibility of crude nutrients for fullgrown wethers and 60 to 80-, 80 to 100-and 100 to 120-day-old lambs which had been ablactated at an age of 60 days. The digestibility for wethers was significantly higher than for lambs, between the age groups of which there were no significant differences concerning the digestibility. In accordance with the results with rations on the basis of concentrated feed as checked and described in the first piece of information, the content of crude fibres in the rations had a negative influence on the digestibility of organic matter, NFE and energy whereas there was a positive relation with the digestibility of crude fibres. The regression functions established for mixtures of straw and concentrated feed concerning the dependence of the digestibility on the content of crude fibres showed a relatively good coincidence in the range of a low content of crude fibres with the corresponding regression functions which were described in the first piece of information for rations of concentrated feed. The equations for the digestibility of crude fibres were an exception. In contrast to this, the quantitative relations between crude fibres and the digestibility as established in the first piece of information for rations with a low content of crude fibres cannot be transferred to rations with a higher content of crude fibres.

Animal Feed↗
PubMed1979

[The nitrogen retention of early weaned lambs].

At 30-to-60-day-old lambs reared without mothers 23 different feed mixtures were tested in N-balance experiments. The following results were achieved: The concentration of digestible crude protein and energy as well as the relation between them (PEQ) have no significant influence on the lambs' nitrogen retention. The energy intake and the intake of digestible crude protein have an intensive, significant influence on nitrogen retention. Rising energy and N-intake within the limits on which the investigation is based increased nitrogen retention. Of the protein feedstuffs tested, a 6 ... 7% higher nitrogen retention was realised from soybean oil meal as the sole source of proteins with 35% retained nitrogen related to the nitrogen intake in comparison to the combinations soybean oil meal/dried skim milk resp. fish meal. Increasing dried yeast portions (greater than 5%--20%) in the feed mixture diminished nitrogen retention. On the basis of the existing results the following recommendations for the use of the tested protein feedstuffs in rearing feed for lambs can be formulated: Soybean oil meal can be used as the sole source of protein in rearing lambs. The use of up to 5% dried yeast in the rearing feed as protein source and for vitaminisation is possible; 20% however diminish nitrogen retention. Because of the positive effect on feed intake it appears suitable to use fishmeal in the rearing feed for lambs.

Animal Feed↗
PubMed1978

[Empirical examination of training programs for the treatment of speech anxiety].

This study is the result of an attempt to get effective methods in order to reduce the students' speaking anxiety in seminars. In a prepost-design, two training programs are compared: systematic desensitization and assertive training. Success is controlled with the help of a subjective anxiety scale, the "Freiburger Persönlichkeitsinventar" (FPI), and by scanning how often and how long somebody is speaking in a seminar. The main results are: both of the training programs reduce speaking anxiety signficantly (perhaps with a little more success of SD), SD also reduces "Gehemmtheit" (FPI-Scale 8). There is a lot of difficulties with regard to the observation of the behavior variables but it seems to be that Ass increases speaking frequency in relation to the groups' mean, while this effect could not be supposed according to SD. At the end of the article, the results are discussed and some questions are raised with regard to the further research of training programs.

Adult↗
PubMed1976

[Determination of urea in the ruminal fluid of sheep].

Low values for urea were found in samples of ruminal fluid of sheep fed concentrate rations if urea determination was carried out by the urease method. The present paper describes a both simple and sensitive colorimetric method of analysis using diacetyldioxime. The method is suitable for determining urea in coloured solutions such as ruminal fluid or silage extracts.

Animals↗