Biomedical subjects

M Hoff

Publications and source records attributed to M Hoff.

At least 73 records · Page 4Linked to original sources

PubMed1989

[Peripheral thyroid insufficiency. Criteria of equilibrium in treatment with L-thyroxine].

During treatment of primary hypothyroidism, the respective values of hormonal assays (total and free T4 and T3, ultrasensitive TSH assay, TRH test) and of the serum markers from peripheral tissue response to thyroid hormones used to detect overdosage are matter to debate. Thirty-four female patients with hypothyroidism, aged 38 +/- 7 years (mean +/- SD) were studied. the mean dose of L-thyroxine required to obtain clinical euthyroidism was 100 +/- 35 micrograms/day. Thyroid hormone and TSH concentrations were measured 20 to 24 hours after the last dose of L-thyroxine and after fasting overnight and were compared with the concentrations obtained in 45 euthyroid controls aged 32 +/- 10 years.

Adult↗

PubMed1989

Thyroid function tests in ageing and their relation to associated nonthyroidal disease.

Thyroid function tests of 179 euthyroid geriatric inpatients (83 +/- 6 yr) unaffected by acute diseases or malnutrition were investigated and compared with those of 76 ambulatory healthy younger subjects (42 +/- 13 yr). Elderly population was divided in three groups, respectively: group G I (n = 37, 65-78 yr), group G II (n = 64, 79-85 yr) and group G III (n = 78, over 85 yr). Severity-of-illness index of the patients was evaluated at entry in the study protocol. While total thyroxine (TT4), free triiodothyronine (FT3) and TSH levels remained unchanged, circulating total triiodothyronine (TT3) was significantly lower (113 +/- 32 vs 150 +/- 31 ng/dl, p less than 0.05) and free thyroxine (FT4) was significantly higher (12.4 +/- 2.7 vs 10.3 +/- 2.3 pg/ml, p less than 0.05) in aged people. Furthermore, TT3 decreased significantly from 130 +/- 36 in G I to 110 +/- 33 in G II and to 108 +/- 25 in G III (p less than 0.01), and FT4 increased progressively although not significantly in the same groups. A close correlation was found between TT3 and severity index in male observations only (r = -0.43, p less than 0.01), as well as between FT4 and severity index in both sexes (r = 0.51, p less than 0.001 for men, r = 0.21, p less than 0.01 for women). These data suggest that thyroid function tests have to be cautiously interpreted in a geriatric population, particularly in relation to the severity of the clinical state, and reference values should be determined for TT3 and FT4 in the ageing process.

Age Factors↗

PubMed1988