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M Hodara

Publications and source records attributed to M Hodara.

47 records · Page 3Linked to original sources
PubMedDate not supplied

Nifedipine and Raynaud's phenomenon associated with connective tissue diseases.

We have evaluated the therapeutic effect of the calcium-channel blocking agent nifedipine in Raynaud's phenomenon associated with connective tissue diseases and in idiopathic digital vasospasm. Thirty patients were included in this study: Raynaud's phenomenon was associated with progressive systemic sclerosis (PSS) in ten patients, systemic lupus erythematosus (SLE) in five and rheumatoid arthritis (RA) in three; it was idiopathic (I) in twelve patients. Each patient received, in a double-blind manner and random order, on two consecutive weeks, nifedipine (20 mg three times daily) and placebo. Nifedipine proved to be effective: the mean number of digital vasospastic attacks per week decreased from 20.30 to 5.83 (p less than 0.01). The results in the SLE and RA groups were similar and were pooled. The improvement (in percent decrease) was better in the idiopathic group (90.95) than in the SLE and RA group (78.63, p less than 0.02) and the PSS group (64.02, p less than 0.01).

Adult↗
PubMedDate not supplied

[What should be done in the case of an accidental injection of a sclerosant into an artery? Apropos of a case].

The authors report a case of severe ischaemia following an injection of sclerosant for varicose veins in the legs and discuss the pathophysiology of this accident. It seems that such an accident requires the immediate injection of a massive dose of cortisone; an intravenous infusion containing 400 mg of hydrocortisone hemisuccinate, 400 mg of heparin, 400 mg of Praxilene and 4 ampoules of injectable Tranxene 50; admission to a competent unit, i.e. with experience of this type of accident and the techniques of haemodilution combined with steroid therapy and the use of calcium inhibitors, for example Aldalate, as peripheral antispasmodics. Finally, the authors discuss the precautions which need to be taken in order to avoid such accidents, even in the hands of experts.

Arteries↗