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Biomedical subjects

M Hobsley

Publications and source records attributed to M Hobsley.

At least 127 records · Page 7Linked to original sources
PubMed1970

Positioning of subject and of nasogastric tube during a gastric secretion study.

The histamine-infusion test was conducted in 50 subjects with a modification that allowed the completeness of recovery of the maximal gastric secretion to be assessed. The effects of the exact position of the tube and the position of the subject on the completeness of recovery were investigated. A simple water-recovery test was found to be as reliable as fluoroscopy for showing that the tip of the tube was within the stomach. Provided that the tip was within the stomach, the exact position of the tube did not affect recovery. Furthermore, recovery in 19 subjects was not appreciably affected by changing the person from the left lateral to the supine semirecumbent position.

Adult↗
PubMed1969

Use of an inert marker (phenol red) to improve accuracy in gastric secretion studies.

Gastric secretion from 24 subjects was collected by continuous nasogastric aspiration during the plateau of secretion evoked by intravenous histamine diphosphate, 0.01 mg/kg/hr. Simultaneously, phenol red was instilled at a constant rate into the proximal part of the stomach. Concentrations of phenol red in 15-minute aspirates were measured, and used to deduce pyloric losses and the reasons for random variation in the volumes aspirated. The average coefficient of variation in the volume was 26%, irrespective of the nature of the nasogastric tube. Correction by phenol red reduced this value to 21%. The coefficient of variation of volume diminished as secretion rate increased. Pyloric losses amounted to 7 ml/15 min, and were independent of the secretion rate. The quantitative effect of these errors upon the assessment of gastric secretion was minimal at high secretion rates but important at low rates.

Adult↗