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Biomedical subjects

M Hitchcock

Publications and source records attributed to M Hitchcock.

At least 37 records · Page 2Linked to original sources
PubMed1966

Comparative detoxication. The detoxication of aromatic acids by invertebrates: detection of agmatine conjugates in scorpions.

1. Benzoic acid and p-nitrobenzoic acid were converted in the scorpion Palamnaeus into N(1)-benzoylagmatine and N(1)-p-nitrobenzoylagmatine. 2. Some benzoyl- and p-nitrobenzoyl-arginine were also formed and these compounds were probable precursors of the agmatine derivatives. 3. p-Nitrobenzoyl- and p-aminobenzoyl-arginine were formed in millipedes dosed with the aromatic acids. 4. Woodlice excreted p-amino- and p-nitro-benzoic acid as their glycine conjugates and no conjugation could be found in the crab Gecarcinus and a freshwater crayfish Astacus.

Animals↗
PubMedDate not supplied

Bone tumor radiograph review by pathologists prior to pathologic diagnosis: a receiver operator curve analysis of diagnostic utility.

Radiologic-pathologic correlation has long been considered a prerequisite for the accurate diagnosis of bone lesions. We investigated using receiver-operating characteristic analysis the accuracy of histopathologic diagnoses with and without pathologist review of radiographs. While accuracy of diagnosis did improve when the radiographs were reviewed by the pathologist, this increase did not reach statistical significance (P=0.1311). Potential reasons for this finding including case selection and reviewer expertise are discussed. Based on our study, the review of radiographs did not result in a statistically significant difference in accuracy of the pathologic diagnosis of bone tumors. However, our data suggest that there may be a difference particularly in selected cases and among certain observers.

Bone Neoplasms↗
PubMedDate not supplied

Alteration of in vivo zoxazolamine metabolism by carbon monoxide in normal and polycyclic hydrocarbon-treated immature male rats.

The effect of carbon monoxide exposure on the in vivo metabolism of zoxazolamine in normal (corn oil-treated) and 3,4-benzpyrene- and 3-methylcholanthrene-treated, immature, male rats was examined. Pre-exposure of the animals for 90 min followed by determination of the duration of drug action while the animals were maintained in the experimental atmosphere resulted in a qualitative difference in response between normal and polycyclic hydrocarbon-treated animals over the concentration range of 150-450 ppm CO. Corn oil-treated animals demonstrated a decreased duration of drug action when exposed to CO, indicating an increase in the bioavailability of drug for metabolism which may be a result of an increase in liver perfusion rates. In contrast, polycyclic hydrocarbon-treated animals demonstrated an increased duration of drug action on exposure to CO. The qualitative difference in response to CO exposure in the two groups of animals may be due to differences in the sensitivity of cytochrome P-450 and cytochrome P-448 with respect to complexing with CO or to lowered intracellular PO2; or to differences in the dependency on blood flow of the rate of in vivo metabolism of zoxazolamine.

Animals↗
PubMedDate not supplied

Outcomes of the first Family Practice Chief Resident Leadership Conference.

In June 1989 the first Family Practice Chief Resident Leadership Conference was presented to 27 Texas second-year residents who had been selected to serve as chief residents during their third year. The objectives of the conference were to assist these emerging leaders to develop better stress management and leadership skills and to strengthen their ties with the Texas Academy of Family Physicians. The conference featured two major workshops on stress management and leadership skills, and included plenary speeches and large and small group discussions. This article reports the outcomes of the conference as measured by the evaluation instrument completed by participants. Analysis of the results indicated that the conference had a positive effect on the residents.

Curriculum↗
PubMedDate not supplied

Promotion criteria for family practice residents: perceptions of program directors.

This study utilized a modified Delphi technique to identify criteria considered important in the promotion of family practice residents. A designated expert panel consisting of the directors of the family practice residency programs in the State of Texas was used as the data source for the study. The Delphi results revealed a marked degree of consensus among the state program directors for 16 of 20 criteria evaluated. The criteria identified did not define comprehensive competency areas or goals. Further studies utilizing this information to develop comprehensive goals or to evaluate a program's current policies are proposed.

Delphi Technique↗
PubMedDate not supplied

Anaesthesia for day-case surgery.

With the current expansion of day surgery, many patients scheduled for elective surgery in British hospitals will receive their treatment on a day basis. Day-case anaesthesia exerts a profound effect on the success and feasibility of day-case surgery. Inpatient anaesthetic techniques are not always the most suitable in this area where even minor morbidity is important. This article examines the differences between inpatient and day-case anaesthesia, and makes a case for the increased recognition of the special requirements of the day-case patient.

Adolescent↗