Rupture of renal angiomyolipoma: conservative surgery.
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
M Hirsch
Publications and source records attributed to M Hirsch.
Subdural empyema of sinus origin in children.
Two children with subdural empyema of paranasal sinus origin presented as neurological emergencies. Both had severe acute pansinusitis with complicating subdural empyema. The need for a high index of suspicion in the proper clinical setting is mandatory even in the absence of confirmatory contrast studies. Surgical proof should be immediately followed by adequate treatment. The high mortality rate even in the antibiotic area calls for this approach.
Adolescent↗
Intrauterine balloon catheter in the CT evaluation of pelvic masses.
A simple method of pelvic computed tomography after the inflation of a Foley balloon catheter in the uterine cavity is described. This method allows precise localization of the uterine corpus and determination of the relationships between normal and abnormal pelvic structures.
Adult↗
Klinefelter's and Takayasu's syndromes in one patient--a pure coincidence?
The patient is a classical case of Klinefelter's syndrome and has, in addition, pulseless disease. In angiography, the involvement of the subclavian arteries and its main branches, consistent with Takayasu's arteritis type 1, was demonstrated. It is a pure coincidence that the patient with a 47 XXY karyotype also has an illness that affects mostly women?
Aortic Arch Syndromes↗
Quick-freezing technique using a 'slamming' device for the study of corneal stromal morphology.
Explore the source record for details and available documents.
Animals↗
Virus-specific IgG and IgM antibodies in normal and immunocompromised subjects infected with cytomegalovirus.
Levels of IgG and IgM antibodies t human cytomegalovirus (CMV) were measured using a solid-phase radioimmunoassay. Individuals positive by complement-fixation test consistently had detectable IgG titers by radioimmunoassay, but no quantitative relationship was apparent. An elevated IgM titer was considered specific for CMV infection because sera from individuals with other herpesvirus infections did not cross-react. In patients with mononucleosis, elevated titers of IgM antibody to CMV correlated (P less than 0.001) with active infection and were highest during viremia. Titers of IgG antibody to CMV during and after symptomatic infection were similar to those of asymptomatic positive individuals. Increases in CMV-specific IGM were observed in both primary and reactivated infections in cardiac transplant recipients. In a small group of cardiac transplant recipients with recurrent symptomatic disease, IgM titers were low at the time of viruria and did not increase with CMV tissue involvement, a result which suggests that quantitative deficiencies in IgM may be related to the severity of CMV infections.
Antibodies, Viral↗
BK papovavirus infections in renal transplant recipients: contribution of donor kidneys.
Infections due to BK papovavirus frequently occur in renal transplant recipients [2] and may be involved in a variety of syndromes, including ureteral obstruction, deterioration of graft function, and pancreatic disease. The source of the BK papovavirus in these cases is not clear. Because the renal allograft has been implicated as a source of primary cytomegalovirus infections in renal transplant recipients [3], we investigated the possibility that donor kidneys may also contribute to the transmission of BK papovavirus. A fourfold or greater increase in titers of HAI antibodies to BK papovavirus was observed in 55 (24%) of 230 renal transplant recipients. Seronegative recipients who received kidneys from seropositive donors were 3.5 times more likely to develop an infection due to BK papovavirus than were seronegative recipients of kidneys from seronegative donors. The antibody status of the donor did not affect the likelihood of an increase in titers of antibody to BK papovavirus in seropositive recipients. These results suggest that BK papovavirus may be transmitted with transplanted kidneys and that transplant recipients who are at risk for primary infection by this route are more than twice as likely to have increased titers of antibody to BK papovavirus as those who are at risk for the reactivation of an infection. Further studies should be performed to define the relative role of cadaver vs. living, related kidney donors in the transmission of BK papovavirus and the clinical syndromes that are related to primary and reactivated infections.
Humans↗
Angiographic diagnosis and treatment of hemobilia.
Hemobilia (bleeding from the biliary tract) may be secondary to trauma, inflammatory disorders, gallstones, or tumor. Although it used to be rare, it is becoming more frequent due to trauma, including iatrogenic causes. The etiology is established by selective angiography, which also facilitates embolic occlusion of the arterial branches supplying the lesion. Nonsurgical control is preferable to surgical management. Two cases are reported, emphasizing the etiologic and therapeutic aspects of interventional studies of the liver.
Adult↗
Gastric cytoprotection by antacids and papaverine in rats.
Prostaglandin E2 (PGE2) prevented hemorrhagic ulceration of rat stomach mucosa induced by various procedures when given orally at a non-antisecretory dose. This effect of PGE2 is called gastric cytoprotection. We used absolute ethanol, 0.6 N hydrochloric acid and 0.2 N sodium hydroxide as damaging agents. Ranitidine at an antisecretory dose did not exhibit any cytoprotective effect. However, the poorly absorbable antacids, magnesium hydroxide plus aluminium hydroxide and aluminium phosphate inhibited the development of hemorrhagic lesions significantly. A similar protective effect was seen after intragastric administration of papaverine, which is known to stimulate endogenous prostaglandin synthesis. However, the question as to whether or not stimulation of endogenous prostaglandin synthesis is the mode of action of the cytoprotective effect of papaverine and poorly absorbable antacids, cannot yet be answered.
Aluminum Compounds↗
Enterocolitis complicating chrysotherapy. Case report and review of the literature.
We report a case of a 71-yr old man with seronegative rheumatoid arthritis, who developed severe enterocolitis during gold therapy. Radiological studies, endoscopy and biopsies showed diffuse involvement of the stomach, duodenum and small and large intestines. The clinical course was prolonged and complicated by multiple infections. Of the 10 cases with chrysotherapy-induced enterocolitis reported in the literature, 3 were from Israel. There may be a relationship between the development of enterocolitis following gold therapy, ethnic group and HLA-B8 and DRw3 antigens.
Aged↗
Combined percutaneous diagnostic puncture and management of renal cysts.
Significant reduction in size was obtained in 12 of 14 renal cysts treated by the instillation of iophendylate. The advent of noninvasive methods has increased the number of renal cysts detected radiologically and has limited the indication for diagnostic puncturing to problematic cases only. However, if it is decided to perform diagnostic puncture of a renal cyst, the combined instillation of iophendylate into the cyst seems to be therapeutically rewarding.
Aged↗
A case of interstitial pneumonitis during amiodarone therapy.
Explore the source record for details and available documents.
Alveolitis, Extrinsic Allergic↗
Monoclonal antibody against cell surface glycoprotein of neurons.
A monoclonal antibody, named BSP-2, has been produced against glycoproteins extracted from neonatal mouse brain. Its reactivity with live cells established the surface location of the antigen. In primary cultures of dissociated cerebellar cells, the antibody bound to neuronal cell types, but not to astrocytes nor to fibroblasts. Immunoprecipitates prepared with the BSP-2 antibody contained a triplet of high-molecular weight glycoproteins with apparent molecular weights of 180,000, 140,000 and 120,000.
Animals↗
Regeneration of the human corneal endothelium.
The ability of the human corneal endothelium to regenerate is studied with the scanning electron microscope through examples of corneal diseases and penetrating keratoplasties. This study does not lead to final conclusions on the possibilities of regeneration of the human corneal endothelium but allows us to say that: --regeneration occurs through size increasing and deformation of the remaining cells. --the increase in number and size of surface microvilli may simply indicate a state of cell activation. --the presence of two nuclei in one cell is probably obtained by amitotic division but no complete mitosis has been seen. --Displacement of endothelial cells is a real progression and the cell is able to overcome obstacles. --the fibroblastic transformation of the endothelial cells is present in man but this may simply represent the migrating form of the cells.
Cornea↗
Application of information theory to clinical diagnostic testing. The electrocardiographic stress test.
The inherent imperfection of clinical diagnostic tests introduces uncertainty into their interpretation. The magnitude of diagnostic uncertainty after any test may be quantified by information theory. THe information content of the electrocardiographic ST-segment response to exercise, relative to the diagnosis of angiographic coronary artery disease, was determined using literature-based pooled estimates of the true- and false-positive rates for various magnitudes of ST depression from less than 0.5 mm to greater than or equal to 2.5 mm. This analysis allows three conclusions of clinical relevance. First, the diagnostic information content of exercise-induced ST-segment depression, interpreted by the standard 1.0-mm criterion, averages only 15% of that of coronary angiography. Second, there is a 41% increase in information content when the specific magnitude of ST-segment depression is analyzed, as opposed to the single, categorical 1-mm criterion. Third, the information obtained from ECG stress testing is markedly influenced by the prevalence of disease in the population tested, being low in the asymptomatic and typical angina groups and substantially greater in groups with nonanginal chest pain and atypical angina. The quantitation of information has broad relevance to selection and use of diagnostic tests, because one can analyze objectively the value of different interpretation criteria, compare one test with another and evaluate the cost-effectiveness of both a single test and potential testing combination.
Electrocardiography↗
Diabetic glomerulopathy may be preventable.
Variation in blood glucose levels throughout the day was assessed in six diabetic maintenance hemodialysis patients and six diabetic renal transplant recipients. None of the twelve studied patients had good control. Glucose levels greater than 300 mg/dl were noted in four of six dialysis patients and five of six transplant recipients. A regimen of self blood glucose measurement and multiple insulin doses was instituted for four transplant and three dialysis patients. Each patient achieved the desired glucose range of 60 to 120 mg/dl most of the time, with a resultant fall in mean hemoglobin A1c concentration from 10.3% to 7.9%. It is suggested that a long term trial of self glucose monitoring might prove beneficial to treated uremic diabetics.
Adult↗
Identification and characterisation of two surface glycoproteins on cultured cerebellar cells.
Two high molecular weight surface glycoproteins of cerebellar cells which are selectively labeled by lactoperoxidase-catalyzed iodination of monolayer cultures from the developing mouse cerebellum, have been identified and partially characterised. Both molecules, called peak 2 and peak 3 proteins, were the major glycoprotein species detected in cerebellar cell cultures after labelling with various radioactive sugars. The freshly iodinated molecules were firmly bound to the cells, but they were released into the medium upon prolonged incubation on the cultures. The soluble peak 2 and peak 3 proteins recovered from the medium comigrated on SDS-polyacrylamide gels with their cell-bound counterparts. Thus, their release results from mechanisms other than extensive degradation. The soluble proteins eluted from gel columns corresponding to molecular weights of over 500,000 and around 300,000, for peaks 2 and 3, respectively. They bound to and were specifically eluted from concanavalin A-Sepharose columns. Peak 3 protein could be easily identified as the most prominent iodinatable polypeptide in cerebellar cell cultures. Its surface expression depended on the presence of neuronal cells. After degeneration of neuron-like cells, a component of greater molecular weight than peak 3 or 2 was predominantly labeled by surface iodination. Peak 2 protein was quantitatively precipitated from labeled culture medium by two heterologous antiseRA. Anti-peak 2 activity was removed from the antiserum by absorption with adult mouse brain, but not by liver, spleen, thymus, kidney, heart and lung. Thus, peak 2 protein may be considered as a brain-specific glycoprotein.
Animals↗