Biomedical subjects

M Hirsch

Publications and source records attributed to M Hirsch.

At least 199 records · Page 11Linked to original sources

PubMed1975

Familial non-cystic fibrosis mucus inspissation of respiratory tract.

Perlman, M., Williams, J., Hirsch, M., and Bar-Ziv, J. (1975). Archives of Disease in Childhood, 50, 727. Familial non-cystic fibrosis mucus inspissation of respiratory tract. Two sibs, whose parents are first cousins, have had chronic obstructive airways disease from birth with recurrent otitis media, sinusitis, and mastoiditis. The disease, associated with clinically abnormal mucus, differs from other familial obstructive airways diseases and probably constitutes a new entity.

Airway Obstruction↗

PubMed1975

Isolated anomalous right ventricular muscle bundle in the asymptomatic adult.

Muscular obstruction to right ventricular outflow is usually at the infundibular level, but, less commonly, it can occur within the body of the ventricle due to an anomalous muscle bundle. This lesion is almost always associated with a ventricular septal defect or other cardiac lesions, and is usually discovered in infancy or childhood. Two asymptomatic adults with severe obstruction due to right ventricular muscular band as an isolated lesion are presented. The lesion can be tentatively diagnosed on clinical grounds and confirmed by angiocardiography. The advisability of surgical correction in the asymptomatic adult with such an isolated lesion is uncertain.

Adult↗

PubMed1975

Pseudoaneurysm of the left ventricle after myocardial infarction: A curable form of myocardial rupture.

Rupture of the myocardium following an acute infarction is occasionally compatible with survival. In such cases, pre-existent pericardial adhesions confine the bleeding to a limited space within the pericardial sac and produce a chamber which communicates with the left ventricular cavity. The chamber gradually enlarges and forms a pseudoaneurysm. Two cases are described in which the diagnosis was made preoperatively and the pseudoaneurysm was surgically resected. Twenty-one previously reported cases are reviewed, as well. The condition's progressive nature leading to death from heart failure or rupture of the pseudoaneurysm, and its amenability to surgical cure make it imperative that the diagnostic features be well known. The diagnosis should be suspected in cases of progressive heart failure developing shortly after the acute phase of myocardial infarction, in which chest roentgenograms show an enlarging heart shadow characterized by a distinct posterior or lateral bulge. The diagnosis can be confirmed by left ventriculography, which should be performed immediately in all suspected cases.

Angiocardiography↗

PubMed1975

Quadruple valve commissurotomy.

A 12-year-old girl in congestive heart failure was diagnosed to be suffering from severe polyvalvular disease due to a combination of congenital and rheumatic lesions. Cardiac catheterization demonstrated stenotic lesions of all the heart valves. The child underwent quadruple valve commissurotomy and is symptom free and thriving 2 years later.

Child↗

PubMed1975

The aetiology of senile osteoporosis: secondary hyperparathyroidism due to renal failure.

The aetiology of senile osteoporosis was investigated in a series of elderly normal persons (mean age 76.8 years) who were compared to 18-19 year old normal controls. Osteoporosis was estimated by standard radiological morphometric and densitometric techniques, in the metacarpals and thoraco-lumbar vertebrae. Serum parathyroid hormone levels were significantly higher in the elderly group, and correlated well with morphometric and densometric measurements of osteoporosis. Creatinine clearance was reduced in seven out of nine of the elderly group, and correlated well with the degree of osteoporosis. Serum thyrocalcitonin levels were reduced in the elderly. Tubular reaborption of phosphate and TmP/GFR were in the hyperparathyroid range in the elderly group and correlated well with the degree of osteoporosis. The hypothesis is advanced that the osteoporosis of old age is a result of parathyroid overactivity, caused by asymptomatic chronic renal failure. The suggestion is made that a diet low in phosphorus might reduce the incidence of osteoporosis in old age by reducing the parathyroid overactivity.

Adolescent↗

PubMed1975

[Regeneration of corneal endothelium in the rabbit: microscopic study and relation with corneal thickness].

The corneal cells are destroyed within a 10 mm diameter circular belt by liquid nitrogen application in vivo. The endothelial regeneration is followed from day to day using endothelial flat preparation technic, and is compared to the corneal thickness measurement and to the estimation of transparency. From the 5th day, Descemet's membrane is entirely covered by the regenerated endothelium; from this time, both thickness and transparency of the stroma become normal. Therefore, in spite of the persitence of morphologic abnormalities, the regenerating endothelial cells preserve or obtain again very rapidly their specific function of a barrier against hydration of the stroma.

Animals↗

PubMed1974