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Biomedical subjects

M Hirano

Publications and source records attributed to M Hirano.

At least 757 records · Page 42Linked to original sources
PubMed1977

Serum glycylproline p-nitroanilidase activity in blood cancers.

Glycylproline p-nitroanilidase activity in serum of patients with acute lymphatic leukemia, lymphosarcoma and Hodgkin's disease, and of normal neonates (umbilical blood) was significantly lower than that of normal adult controls. In contrast, the enzyme activity of patients with myelocytic leukemias did not differ significantly from that of normal controls.

Dipeptides↗
PubMed1976

Dynamic changes of serum LH and FSH during pregnancy and puerperium.

Changes of serum LH (HCG) and FSH, and their response to LH-RH during pregnancy and puerperium were studied by radioimmunoassay. There was little change in serum FSH level due to progression of pregnancy, and the serum FSH level of pregnant women was almost unchanged after injection of LH-RH. Serum LH (HCG) which decreased rapidly after delivery returned at about 15 days after parturition, and FSH which remained at a low level during pregnancy returned to the levels in the follicular phase of the normal women at about 20 days after delivery. The alteration in the response to LH-RH in puerperal period was as follows: First FSH began to respond about 10 days after delivery, and one month after parturition both LH and FSH showed remarkable response in comparison with that in the normal non-pregnant period. Beyond the second postpartal month, the response of FSH returned to approximately the same level as that in the normal non-pregnant period, but the response of LH was still marked when compared with that in the non-pregnant period. There were no differences in the response to LH-RH between the nursing and non-nursing women.

Breast Feeding↗
PubMed1976

LH- and FSH-releasing activities of synthetic tetrapeptide and synthetic LH-RH in rats.

Changes in serum LH and FSH were measured following injection of synthetic tetrapeptide (Glu-Tyr-Arg-Trp-NH2) or synthetic LH-RH into the femoral vein of oophorectomized rats. A considerable secretion of LH occurred after injection of synthetic tetrapeptide although its LH-releasing activity was less prominent than that observed after injection of LH-RH. No appreciable FSH-releasing activity was noted following injection of the tetrapeptide. A significant rise of LH and an observable, but extremely modest, rise of FSH with an indistinct peak were noted after single injection of synthetic LH-RH.

Animals↗
PubMed1976

Histopathological findings of the ovaries in anovulatory women.

Wedge resection of the ovary was carried out in 45 anovulatory women to study the correlation between the degree of disturbance of ovulation and the histopathological findings. Polycystic ovary was always found in patients with anovulatory cycles. The ovaries in grade 1 amenorrhea showing withdrawal bleeding in response to gestagen alone belonged to the nonspecific type, polycystic type and sclerotic type. These histological changes were relatively mild in many cases. The ovaries in grade 2 amenorrhea showing withdrawal bleeding in response to estrogen and gestagen but not to gestagen alone belonged to the non-specific type, polycystic type, sclerotic type, atrophic type and streak type. Even within the same histological entity, the histological findings of the ovaries were more pronounced in grade 2 amenorrhea than in grade 1 amenorrhea. The patients with primary amenorrhea had only hypoplastic and aplastic ovaries with marked histological abnormalities.

Adult↗
PubMed1976

[Clinical studies on gentamicin in complicated urinary tract infections (author's transl)].

Twenty cases with complicated urinary tract infections were treated with gentamicin. Good results were obtained in 7 of 14 cases with chronic pyelonephritis and 2 of 4 cases with chronic cystitis and in 1 of 2 cases with acute prostatitis. No side effect was observed throughout this treatment. But in laboratory examination, slight elevation of S-GOT and S-GPT was observed in 3 of 20 cases after gentamicin treatment.

Acute Disease↗