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Biomedical subjects

M Hinton

Publications and source records attributed to M Hinton.

106 records · Page 6Linked to original sources
PubMed1973

Salmonella dublin abortion in cattle. I. Observations on the serum agglutination test.

The somatic and flagellar serum agglutinin titre were determined in paired samples obtained from seventy-seven cases of bovine abortion associated with Salmonella dublin infection. The cases could be divided into four serological groups with an active infection being demonstrated in most cases. The serum agglutination test was shown to be a relatively specific diagnostic test but was of more limited value in the retrospective identification of convalescent cases.

Abortion, Veterinary↗
PubMed1973

Salmonella dublin abortion in cattle. II. Observations on the whey agglutination test and the milk ring test.

The serum and whey agglutination test were compared on paired samples from thirty-five cases of bovine abortion associated with Salmonella dublin infection. The whey test proved nearly as useful as the serum test for confirming an active infection though it was only practicable to examine the whey for flagellar antibodies. S. dublin was isolated from nearly half of the milk samples obtained within the first week of abortion but none of those collected after the fourth week. The whey test proved of no value in retrospective identification of abortion cases. The trial using the milk ring test was disappointing.

Abortion, Veterinary↗
PubMedDate not supplied

The humoral and cell mediated immune response of young chicks to Salmonella typhimurium and S. Kedougou.

Day old chicks were inoculated with either Salmonella typhimurium or S. Kedougou as representative examples of an invasive and a non-invasive strain respectively. The titres of IgA, IgG and IgM antibodies were determined, using an enzyme-linked immunosorbent assay (ELISA) in the bile, serum and homogenates of intestinal mucosa each week up to 5 weeks of age. Statistically significant increases in antibodies were detected in the bile (IgA and IgG) and the intestinal mucosa and serum (IgG and IgM) 1 week after the birds were inoculated with S. typhimurium. In contrast, only a limited response was recorded for S. kedougou 4 weeks after challenge commenced. The birds appeared capable of eliminating systemic infection with S. typhimurium as they grew older although a cell mediated immune response was demonstrated in less than half the birds aged 4 or 5 weeks. The demonstration of only a limited serological response to S. kedougou indicates that serological testing may have a limited role in monitoring flocks for infection with non-invasive serotypes.

Animals↗
PubMedDate not supplied

Pathological findings in the intestinal tract and liver of chicks after exposure to Salmonella serotypes Typhimurium or Kedougou.

Day-old chicks were inoculated either via the feed or by direct oral inoculation with salmonellas which were either invasive or non-invasive (serotypes Typhimurium and Kedougou, respectively). Colonization of the alimentary tract and visceral organs, determined by microbiological examination, occurred more quickly in birds inoculated orally with S. serotype Typhimurium compared with feed-challenged birds. By contrast, S. serotype Kedougou remained confined to the alimentary tract. In birds inoculated either orally or via the feed, S. serotype Typhimurium, but not serotype Kedougou, was identified in the lamina propria of the caecum by immunostaining. Electron microscopic examination confirmed that the organisms were within macrophages.

Animal Feed↗