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Biomedical subjects

M Hillman

Publications and source records attributed to M Hillman.

At least 37 records · Page 2Linked to original sources
PubMed1992

Evaluation of a robotic workstation for the disabled.

Experience with potential users is vital at all stages of the design of equipment for the disabled, not least in the field of rehabilitation robotics. The development of a robotic workstation for the disabled has progressed, over a period of 6 years, from the use of a cheap educational arm, to a specially engineered robot arm and workstation. The design and specification has been refined through constant evaluation by disabled users. Trials at a spinal injuries unit have given approval to the design and appearance of the latest robot arm and workstation, and have led to modifications to the user interface and software. Further trials have taken place in a user's home to investigate in greater depth the usefulness of a robotic workstation in a practical situation. The results of these trials are presented. It is proposed to refine the design of the arm for low-volume production, easy maintenance in the field and improved appearance.

Adult↗
PubMed1991

Effects of doxorubicin on the sensitivity of L1210 leukemia cells to deformation-associated trauma.

Most of the cancer cells arrested in the microcirculation during hematogenous metastasis are rapidly killed; one major mechanism is surface-membrane rupture, associated with the mechanical deformation of cancer cells in capillaries. The feasibility of increasing the susceptibility of cancer cells to lethal, deformation-associated trauma by doxorubicin, was tested in an in vitro mechanical model system, by filtering suspensions of L1210 leukemia cells through 8-microns pore-size Nuclepore membranes, with or without prior incubation with 10(-7)M doxorubicin. The results showed that mechanically-induced loss of cancer cells immediately after filtration was increased from 18 to 55% in cells previously exposed to doxorubicin for 48 h. The results indicate the feasibility of chemotherapeutic enhancement of the mechanical killing-action of the microvasculature as a potential rate-regulator of hematogenous metastasis.

Animals↗
PubMed1991

Undetectable caeruloplasmin values in a patient with autoimmune chronic active hepatitis.

Caeruloplasmin is an alpha 2 protein produced in the liver that is responsible for transporting copper in the blood. Caeruloplasmin values are usually high in patients with chronic liver diseases, including chronic active hepatitis: low values, however, are characteristic of Wilson's disease. The case of a 17 year old woman with very low caeruloplasmin values and chronic active hepatitis of the lupoid type is described. Steroid treatment resulted in an increase in the caeruloplasmin concentration and clinical improvement.

Adolescent↗
PubMed1991

The lymphocyte transformation test with type II collagen as a diagnostic tool of autoimmune sensorineural hearing loss.

Immunological disorders of the cellular type can be diagnosed by the lymphocyte transformation test (LTT). An autoimmune mechanism of certain cases of sensorineural hearing loss (SNHL) can be evaluated by using human inner ear tissue as an antigen. Recent studies have shown that type II collagen plays an important role, not only in some autoimmune mediated rheumatoid diseases, but also as an antigenic substrate of inner ear tissue in autoimmune sensorineural hearing loss. This paper deals with results of the lymphocyte transformation test using type II collagen as antigen in 68 patients with progressive sensorineural hearing loss (PSNHL) and 68 healthy volunteers. Thirty-four patients showed a strong stimulation in the lymphocyte transformation test, in contrast to only four volunteers in the control group, two of whom had a history of rheumatoid arthritis.

Adult↗
PubMed1991

Elevated creatine phosphokinase and creatine phosphokinase-MB in acute laryngitis.

Elevated creatine phosphokinase (684 mU/ml) and creatine phosphokinase-MB (3.5%, 23.9 mU/ml) were observed in a 66 year old female with acute laryngitis. The patient had received L-thyroxine because of hypothyroidism for 10 years and her T3 and TSH levels were normal. Acute myocardial infarction was denied by repeated EKG findings. The mechanisms of the enzyme abnormality were discussed.

Aged↗
PubMed1991

The public library system. Social services resource for the geriatric population.

The public library system is targeting the geriatric population and instituting programs to meet informational and recreational needs. From retirement planning, visual aids, and screening, to accessing library material to the elderly, the public library system attempts to meet the challenge of providing service to this special population. Although not a formal group, the library has inherent therapeutic effects that benefit the elderly who participate in their programs. The clinician would be advised to take advantage of these various programs. Because each local and regional center will offer different programs, calling a local library is the most effective way to find out what a specific public library system has to offer. Nurses may also consider joint efforts to initiate programs in their library systems to better meet the population's needs.

Aged↗
PubMed1990

Antitumor properties of tetrahydrobenz[a]anthraquinone derivatives.

The compound 8,11-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]- 6-methoxy-1,2,3,4-tetrahydro-7,12-benz[a]-anthraquinone (7) was synthesized from 3,6-dimethoxyphthalic anhydride and 6-methoxy-1,2,3,4-tetrahydronaphthalene by a Friedel-Crafts reaction, cyclization to form a dihydroxyanthraquinone, and conversion into the amino-substituted derivative by reaction with 2-[(2-hydroxyethyl)amino]ethylamine. The new compound, a ring D analogue of mitoxantrone, showed growth inhibition, at micromolar concentrations, of murine leukemia 1210, human lung H125, human breast MCF7, human ovary 121, and human colon WiDr and increased the life span of leukemic mice by 38%.

Animals↗
PubMed1990

Prolonged course of a cutaneous T-cell lymphoma with late systemic involvement.

The clinical course of cutaneous T-cell lymphomas is known to be extremely variable. The disease may be present for up to 50 years, although it has a median survival of four to ten years. Clinical manifestations may range from cutaneous involvement alone to widespread systemic involvement. Described here is a patient with an unusually prolonged course of a cutaneous T-cell lymphoma with systemic involvement which reappeared ten and 18 years after the initial presentation. The patient developed Sjögren's syndrome, bone marrow and peripheral nerve involvement late in the course of her disease.

Adult↗
PubMed1990

Vasculitis and cryoglobulinemia associated with persisting cholestatic hepatitis A virus infection.

Extrahepatic manifestations are rarely found in hepatitis A viral (HAV) infection. Only a single case of HAV infection associated with cutaneous vasculitis and cryoglobulinemia has been reported. Described here is a patient with a persisting cholestatic type of HAV infection who developed cutaneous vasculitis and cryoglobulinemia during the third month of her illness. Analysis of the cryoglobulins revealed IgM anti-HAV antibodies.

Adult↗
PubMed1989

A 15-kD interferon-induced protein and its 17-kD precursor: expression in Escherichia coli, purification, and characterization.

Using recombinant DNA technology, a 15-kD interferon (IFN)-induced protein and its 17-kD precursor have been expressed in Escherichia coli to obtain sufficient quantities of each protein for the investigation of their biological roles. Both the 15-kD and 17-kD proteins have been purified to homogeneity and crystallized. The recombinant 15-kD protein has an identical reversed-phase HPLC elution profile to that of the native 15-kD protein purified from human cells. Furthermore, the recombinant 15-kD and 17-kD proteins have identical amino- and carboxy-terminal amino acid sequences to those predicted from the DNA sequence. The native and recombinant 15-kD proteins give identical tryptic peptide maps, and the recombinant 17-kD protein gives only one additional tryptic peptide. We conclude that the recombinant 17-kD and 15-kD proteins are identical to the 17-kD precursor and the 15-kD stable product synthesized in human cells in response to IFN stimulation. In addition, we have demonstrated that the recombinant 17-kD precursor protein can be converted to the 15-kD protein by cytoplasmic extracts of human cells.

Amino Acid Sequence↗
PubMed1988

A 15-kDa interferon-induced protein is derived by COOH-terminal processing of a 17-kDa precursor.

An interferon-induced 15-kDa protein is synthesized from a precursor of higher molecular weight; the precursor contains 165 amino acids (17 kDa), whereas the stable product (15 kDa) contains 156 amino acids. The stable 15-kDa form is derived from the precursor 17-kDa form by the removal of eight amino acids from the COOH terminus and the methionine from the NH2 terminus. The existence of the precursor 17-kDa protein can be demonstrated after brief periods of in vivo labeling with [35S]methionine and by translation of mRNA in vitro.

Amino Acid Sequence↗
PubMed1979

Relevance of specific activity in experimental erythrocytocide by 55Fe.

Iron loads between 0.20 microgram and 26 microgram, added to 5 mu Ci 59Fe, were followed for up to 150 days in mice. Relative organ uptake increased as a function of iron load in liver and kidneys while it decreased in bone marrow and blood. Several weeks after injection, all load-related differences disappeared.

Animals↗