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Biomedical subjects

M Hida

Publications and source records attributed to M Hida.

At least 91 records · Page 5Linked to original sources
PubMed1983

Suppressive effect of bradykinin to cellular immune responses in vivo and in vitro.

Bradykinin, as well as histamine, one of the mediators in IgE mediated immediate type allergic reactions or acute inflammation, may affect the in vitro and in vivo cell-mediated immune reactions of the immunized animals. It was demonstrated in our present experiment that the appearance of delayed type hypersensitivity (DTH) skin reaction in the immunized guinea pig was remarkably suppressed by treatment of bradykinin or histamine and the suppression of cutaneous DTH by bradykinin was inhibited by H-2 antagonist (burimamide) but not by H-1 receptor blocker (chlorpheniramine). It was also clearly demonstrated that bradykinin suppressed the production of antigen-induced macrophage migration inhibitory factor (MIF) of the immune guinea pig peritoneal exudate cells (PECs) and the production of MIF was blocked by H-2 antagonist (burimamide) or H-2 agonist (tolazolin) but not by H-1 antagonist (chlorpheniramine). Antigen-induced lymphocyte proliferation of the immunized mice, one of the indicators of the cellular immune response, was also suppressed by treatment of bradykinin. These results indicate that bradykinin as well as histamine may have some role in the subsequent expression of cellular immune reactions.

Animals↗
PubMed1982

Age changes in metastatic patterns in renal adenocarcinoma.

The metastatic pattern in primary renal adenocarcinoma with respect to age has been studied by analyzing the necropsy records of 1828 patients. Metastasis-free cases were noticeably frequent in the patients over 70 years of age. The metastatic pattern varied with age and was classified grossly into four types according to the age-associated change in frequency: (1) diminishing; (2) increasing; (3) peaked; and (4) invariable. The incidence of hematogenous metastases showed little or no relation to advancing age whereas dissemination, which was possibly lymphogenous, was found to diminish as the age advanced, the latter trend being especially conspicuous in patients with lymph nodes distant from the primary lesion. It has been inferred that organs displaying comparable tendencies of age-associated change in frequency of metastasis may share the same route of dissemination.

Adenocarcinoma↗
PubMed1982

Metastatic processes and a potential indication of treatment for metastatic lesions of renal adenocarcinoma.

Renal adenocarcinoma findings from 307 autopsied cases with metastasis to 1 and 2 organs were investigated concerning the mode of metastasis. The lung was the most frequent site of metastasis to 1 organ, although the frequency was rather low (30 per cent), followed by bones (over-all), lymph nodes (over-all) and brain, and involving frequently the thoracic spine and retroperitoneal lymph nodes. In patients with metastases to 2 organs a significant correlation was found between the pulmonary-tracheal lymph nodes and those to the lungs. Potential indications for treatment of metastatic lesions were 1) lymphadenectomy and/or radiation therapy for the retroperitoneal and para-aortic lymph nodes and 2) resection of metastatic lesions in the lungs combined with lymphadenectomy and/or radiation therapy for the pulmonary-tracheal lymph nodes. In patients without lung metastasis lymphadenectomy and/or radiation therapy for the pulmonary-tracheal lymph nodes is not always necessary.

Adenocarcinoma↗
PubMed1982

Red blood cell types and living related renal transplantation.

We studied the effects of red blood cell types on 34 cases of living related renal transplantation. Red blood cell types were examined retrospectively concerning the ABO, Lewis, P, Rh-Hr, Kell, Duffy and MNSs systems in both donors and recipients. The correlation between red blood cell type and acute rejection in HLA identical pairs and the effects of the Lewis, P and other systems on graft outcome in HLA semi-identical pairs were considered. In the HLA identical group, the Rh-Hr and MNSs systems participated in acute rejection. In addition to the ABO and Rh-Hr systems, the Lewis and P systems influenced the graft rejection in the HLA semi-identical group.

ABO Blood-Group System↗
PubMed1982

Complication of renal neoplasms with cystic disease: an indication for nephrectomy in potential transplant recipients.

Thirty-five (1.1%) out of a total of 3,133 autopsied cases of renal tumors were complicated by renal malignant tumors and cystic renal disease. They accounted for 1.4% of 2,417 cases of renal malignant tumors and for 4.7% of 751 cases of cystic renal disease. Among the 35 complicated cases, 10 cases or 28.6% were free of metastasis. The incidence of complicated cases and those without metastasis aged over 60 years or over was 12.2% and 29.2% respectively, while the 10-59 year-old age group displayed a lower incidence of 3.6% and the same incidence of 27.3% respectively. In 26 out of 35 cases the malignant tumors was renal adenocarcinoma with no evidence of metastasis in nine cases (34.6%). Although it is unknown whether cystic renal disease undergoes malignant changes, not all of the patients undergoing chronic hemodialysis should be indicated for nephrectomies since such patients with renal malignancies are mostly elderly and are frequently free from metastases.

Adolescent↗
PubMed1982

Report on blood access for hemodialysis in the Department of Transplantation, Tokai University School of Medicine and a satellite hospital.

There were 316 patients being treated by maintenance hemodialysis in the Department of Transplantation, Tokai University School of Medicine and its satellite hospital (Bohsei Clinic, Medical Treatment Cooperation, Showakai) as of December 31, 1981. Forty eight male (23.1%) and 39 female (35.7%) patients were operated on for external shunts. One case of external shunt was functioning well 48 months later. No patient was dialysed through external shunts on December 31, 1981 in our Department or the satellite. The majority of patients, who were maintained on hemodialysis with an arteriovenous (native vein) fistula available, experienced no difficulties. Nearly 50 percent of cases with the first fistula were functioning on December 31, 1981. There were some complications with fistulas such as pseudoaneurysms, infections, the sore thumb syndrome or the steal syndrome. We experienced 14 hemodialysis cases using expanded polytetrafluoroethylene (E-PTFE) grafts and one case using femoral artery repositioning as blood access.

Adolescent↗
PubMed1982

Experience of 26 acute renal failure cases.

Data from 26 patients in acute renal failure biopsy have been analysed to define the highest risk factors and to evaluated the reversibility of renal functions. The overall mortality rate was 38 per cent. The mortality (69%) in postsurgical and traumatic cases was significantly higher than that (8%) in cases of obstetrical and medical origin. Survivors and nonsurvivors did not differ in time of initiation of dialysis. There was an increased incidence of gastrointestinal hemorrhage in those who died. A serious underlying disease, infection and gastrointestinal hemorrhage were mainly responsible for deaths. Five of the 16 survivors were left with renal failure and two of them required chronic hemodialysis.

Acute Kidney Injury↗
PubMed1982

Distant metastasis of urothelial tumors of the renal pelvis and ureter.

Autopsy reports on urothelial tumors of the renal pelvis and ureter in 602 cases were analyzed to investigate the mode of metastasis. Seventy one cases, or 12%, showed no metastasis. Metastasis-free cases occurred with significantly high frequencies in cases of tumors of the ureter and papillomatosis, and less frequently in squamous cell carcinoma cases and in females. Lymph nodes were the most frequent site of dissemination, especially the retroperitoneal and para-aortic lymph nodes. Metastases to the lungs, peritoneum and ipsilateral adrenal were significantly more frequent in cases of tumors of the renal pelvis than in those of tumors of the ureter. Metastases to the retroperitoneal lymph nodes and peritoneum were frequent in cases with metastasis to one organ. Radical nephrectomy with regional lymphadenectomy and/or radiation therapy is indicated for tumors of the renal pelvis. Palliative surgery or nephroureterectomy with a cuff of bladder wall is indicated for tumors of the ureter or papillomatosis, and radical nephroureterectomy with regional lymphadenectomy and/or radiation therapy in cases where a pronounced tendency of down-growth invasion is suspected.

Adenocarcinoma↗
PubMed1982

Renal function after nephrectomy in renal donors.

Six months to 5 years after nephrectomy in renal donors, creatinine clearances and PSP tests of 34 cases had recovered to 81.8% and 68.2% respectively of prenephrectomy performance. Blood urea nitrogen, creatinine and uric acid levels had increased to 24.9%, 36.7% and 24.3% respectively of prenephrectomy values. There was compensatory hypertrophy of the remaining kidney. The mean increase in size of the remaining kidney was 12.0% x 17.8%. There were early complications in 11 (32%) of the donors, in the form of pneumothorax in six cases, wound infection in two cases, hepatitis in two cases and urinary tract infection in one case. There was one late complication of neuralgic pain in the scar region.

Adult↗
PubMed1982

Metastasis of urothelial tumors of the bladder: correlation between sites and number of organs involved.

Urothelial tumors of the bladder in 2,561 autopsy cases were classified according to the number of organs involved in metastasis, and a comparison was made concerning the frequency of the metastases in various organs. In cases with single organ metastasis, lymph node and lung involvement was low (20% and 14% respectively), but it increased as the number of metastatically involved organs increased. The frequency varied depending on the number of organs involved. Three basic types of metastases were established. Type 1: An increase in metastases was seen rectilinearly in accordance with the number of organs involved. Metastases to the lymph nodes (overall), lungs, liver, bones (overall), rectum and retroperitoneal lymph nodes belonged to this group. Type 2: The frequency was low in cases with metastasis to one or two organs, but markedly increased when three or more organs were involved. Metastases to the adrenals, kidneys and pancreas belonged to this group. Type 3: The frequency was almost unchanged, regardless of the number of organs involved. Metastases to the prostate and perivesical lymph nodes belonged to this group. The number of metastatically involved organs is useful in analyzing the mode of metastasis.

Adenocarcinoma↗
PubMed1982

Secondary hyperparathyroidism in patients on maintenance hemodialysis.

I measured levels of serum immunoreactive C-terminal and N-terminal parathyroid hormone (PTH), total serum calcium and ionized serum calcium in patients treated by hemodialysis. There was a correlation between the C-terminal PTH and N-terminal PTH levels. N-terminal PTH levels were not influenced by the age of the patients, but they increased as the period of hemodialysis became longer. The correlation between the level of N-terminal PTH and secondary hyperparathyroidism was good, but there was no correlation between the level of C-terminal PTH and secondary hyperparathyroidism.

Adolescent↗
PubMed1981

Acute irreversible rejection after withdrawal of azathioprine in renal allograft recipients.

Azathioprine was withdrawn from five recipients after renal transplantation because of hepatic damage. In three out of five cases, clinical courses were uneventful for more than 1 year after withdrawal (Group A). In the other two cases, rejection episodes occurred 3 and 5 months after withdrawal (Group B). Differences in histocompatibility, the interval between the operation and withdrawal, and the maintenance dosis of prednisolone were not practically striking in either group, but rejection episodes occurred early in group B. We evaluated the results and considered the mechanisms of tolerance after withdrawal of azathioprine because of hepatic damage in renal allograft recipients.

Adult↗
PubMed1981

Clinical considerations of renal allograft pathology.

Eleven out of 31 cases of living renal allografts lost their graft functions. Causes of graft loss were acute rejection in eight cases chronic rejection in one, graft rupture in one, and death due to meningitis with good graft function in one case. Five renal allografts and two biopsy specimens obtained after acute irreversible rejection and one renal allograft due to acute tubular necrosis an rupture were reviewed. We evaluated the correlation between these findings and the irreversibility of renal graft functions. All removed allografts and biopsies demonstrated interstitial edema and cell infiltration. Vascular pathology due to acute irreversible rejection revealed a high level of severity with fibrinoid necrosis and luminal obliteration. These findings suggested that graftectomy and cessation of immunosuppressants were indicated.

Graft Rejection↗
PubMed1981

Clinical report on hemodialysis in the Department of Transplantation, Tokai University School of Medicine.

The Department of Transplantation, Tokai University School of Medicine was opened in April 1975. There were 286 patients treated by regular hemodialysis and 30 transplantation patients in the five year period from 1975 to 1980 in our Department. The total number of patients treated by regular hemodialysis alive in June 30, 1980 was 244 (85.3%). In the regular hemodialysis group, the peak age was 30-39 years. The youngest patient was nine years old and the oldest was 85 years old. The male : female ratio of chronic renal failure patients treated by regular hemodialysis was 67 : 33%. The actual five-year survival rate for patients treated by regular hemodialysis was 82%. The most prominent cause of chronic renal failure was glomerulonephritis (86.6%). The major cause of death in regular dialysis patients was gastrointestinal hemorrhage (22.6%). We had 81 cases of acute renal failure and 20 (24.7%) of these patients were treated by hemodialysis. Six cases with no acute or chronic renal failure were treated by hemodialysis.

Acute Kidney Injury↗