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Biomedical subjects

M Hettinger

Publications and source records attributed to M Hettinger.

6 recordsLinked to original sources

[Multiple bile duct hamartomas of the liver -- a rare differential diagnosis to liver metastasis].

Multiple bile duct hamartomas of the liver (von Meyenburg complex) are mostly incidental findings at autopsy. The 79-year-old female patient was presented to us with a superinfected Paget lesion of the right nipple. Ultrasound examination of the liver revealed multiple scattered hyperechoic lesions as well as some anechoic lesions, suspicious of metastatic disease. Computed tomography showed multiple focal lesions. The ultrasound-guided needle biopsy of the liver revealed multiple benign bile duct hamartamas. Magnetic resonance imaging ruled out diffuse malignant infiltration of the liver.

Aged↗

[Evaluation of renal artery stenosis: comparison of angiography and invasive blood pressure measurement and Doppler ultrasound].

PURPOSE: In the procedure of renal artery angioplasty, the angiographically measured degree of stenosis should be compared with the intraarterial transstenotic blood pressure gradient and pre-interventional Doppler findings. METHODS: In a total of 46 renal arteries in 35 patients with renovascular hypertension, the angiographic-morphological parameters: "linear", "geometric" and "densitometric" degree of stenosis are compared with the invasive transstenotic blood pressure gradient and the pre-interventional Doppler ultrasound. RESULTS: All angiographically determined degrees of stenosis ("linear", "geometric" and "densitometric") correlate--moderately--with the transstenotic blood pressure gradient (correlation coefficients: 0.67 ("linear"), 0.65 ("geometric") and 0.49 ("densitometric"), each versus systolic pressure gradient, respectively). Stenoses that are angiographically classified as "low grade" (< 50%) nevertheless have a high number of high transstenotic pressure gradients: 21 of 22 show systolic values > or = 10 mmHg, 13 of 22 even > or = 30 mmHg. All stenoses Doppler sonographically classified as "high or very high grade" (Vmax,syst > or = 3 m/s) are confirmed by angiography and/or pressure measurement. CONCLUSIONS: Angiography has the tendency to underestimate the degree of renal artery stenosis, especially in "low grade" stenoses (< 50%). However, in those > or = 50% a high transstenotic blood pressure gradient can be taken for granted. If the angiographic degree of stenosis seems uncertain, we recommend measurement of blood pressure gradient.

Adult↗

Ganglionic herpes simplex and systemic acyclovir.

The therapeutic and systemic effects of acyclovir on ganglionic herpes simplex virus (HSV) in mice were studied by varying the duration of treatment and the time of removal of ganglia for co-cultivation after treatment had ended. When treatment was started three hours after infection, it had a significant therapeutic effect even when the ganglionic culture was delayed 17 days after the end of acyclovir therapy. When treatment was started 24 hours after infection, it had no significant effect under the same circumstances. The treatment of established latent ganglionic HSV for 15 days with acyclovir had a significant therapeutic effect compared with control mice when ganglia were cultured two days after treatment had ended, but this effect was lost by ten and 21 days after the end of therapy. This indicates that acyclovir has a transient suppressive effect on part of the viral ganglionic reservoir, but it also indicates that these titers quickly reestablish themselves with the removal of drug therapy.

Acyclovir↗

Acyclovir and vidarabine in the treatment of ulcerative herpes simplex keratitis.

In a masked controlled study, we treated 41 patients who had active herpes simplex corneal ulcers with either 3% acyclovir of 3% vidarabine ointment five times daily for 14 days. There was no statistically significant difference between the two drugs with reference to mean healing time, efficacy of healing, development of stromal keratitis or iritis, post-treatment visual acuity, or adverse reaction.

Acyclovir↗

Students attend nurses association convention for college credit.

The author describes a college course that facilitates student attendance at the Iowa Nurses' Association (INA) convention and promotes observation of nurse leaders as they consider nursing and political issues. Using the guidelines in this article, nursing faculty can develop a similar course in their institutions and generate student interest in the activities of the state professional associations.

Congresses as Topic↗