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Biomedical subjects

M Heideman

Publications and source records attributed to M Heideman.

48 records · Page 3Linked to original sources
PubMed1978

Complement activation and hematologic, hemodynamic, and respiratory reactions early after soft-tissue injury.

The effect of soft-tissue trauma was studied in dogs. Following injuries to the hind leg an aggregation of thrombocytes in blood and trapping in the lung was noted. Injury was initially followed by leukopenia and later by leukocytosis. Early hemolysis of red cells was observed. The injury was accompanied by complement activation. Its possible relation to hemolysis, leukopenia, thrombocytopenia, and increased insufflation pressure is discussed.

Animals↗
PubMed1977

Surgical management of gastroduodenal haemorrhage.

We have presented a retrospective study of the surgical management of 299 patients bleeding from duodenal ulcer, gastric ulcer or gastritis. The overall mortality rate was 15%-5% for elective and 25% for emergency operations. The mortality increased with age and reached 50% for emergency operations in patients over the age of 70. Patients with low admission haemoglobin values, who had episodes of hypovolemic shock or who required immediate transfusions were also at risk. A Billroth I gastric resection proved to be the safest operative procedure. Based on our results, we are supporting a program calculated to reduce the mortality attending gastroduodenal bleeding, especially in those patients requiring an emergency operation. The basic principles of this program are constant observation, prompt diagnosis and early surgical intervention.

Blood Transfusion↗
PubMed1976

The risk of renal allograft rejection following angiography.

In a retrospective study of 173 immediately functioning primary kidney transplants, correlation between agiography and renal allograft rejection was studied during the first 14 days. It was found that rejection was more frequent in kidneys undergoing angiography than in those not undergoing angiography. It was also found that in kidneys undergoing angiography an overwhelming number of the rejections started the day after angiography. These differences in rejection frequency could not be explained by differences in HLA matching or the origin of the kidneys. These findings suggest a possible connection indicating that the angiography might elicit an acute rejection episode. A possible mechanism for starting this reaction might be activation of the complement system which was found in 50% of the patients undergoing angiography in peripheral blood and in 100% when studied in vitro.

Angiography↗
PubMed1976

Thromboresistance and stability of a heparinized polymer.

Untreated shunts and shunts heparinized according to a modification of the method of Eriksson et coll. were inserted between the femoral artery and vein in mongrels. Scanning electron microscopy of pieces excised at different time periods of exposure to blood was performed. The heparinized surface had excellent thromboresistant properties with no thrombus formation after 4 hours, while the untreated shunts were covered with platelets already within 20 min. The leakage of heparin in vitro was less than 3 per cent of the total wall-bonded heparin during 90 min.

Animals↗
PubMedDate not supplied

The immunologic response to thermal injury.

Thermal injury is associated with altered immune defense. Extensive and deep thermal injuries lead to depressed immune defense function with both cellular and humoral defense affected. There is an intricate interaction between various components of the immune system. The altered specific immune response is seen as a depressed ability to produce active rosette-forming cells. Depressed stimulation of lymphocyte proliferation as well as the mixed lymphocyte response have also been recorded following burns. These effects are modulated by the release of kinins, prostaglandins, anaphylatoxins, superoxides, and leukotrienes, all of which can influence the inflammatory response following thermal injury. The humoral immunity is altered as seen by decreased levels of immunoglobulins, activation of complement with release of anaphylatoxins, and formation of membrane attacking complexes leading to inflammation and cytolysis. The immune response to burns is also affected by factors other than this injury, such as nutrition or diseases such as diabetes mellitus or disorders of the lymphoproliferative type. The immune response is also influenced by some drugs used for other reasons such as steroids, chemotherapeutic agents, and topical agents used for burn wound care. The immune reaction to a burn is also influenced by the additive effect of superimposed infections. Removal of injured tissue without the need for extensive transfusion will improve the ability of the burned patients to use their immune defense system in a fruitful way.

Animals↗
PubMedDate not supplied

The risk of renal allograft rejection following angiography.

In a retrospective study of 173 immediately functioning primary kidney transplants correlation between angiography and renal allograft rejection was studied during the first 14 days. Rejection was more frequent in kidneys undergoing angiography compared to those not angiographied. In kidneys undergoing angiography an overwhelming number of rejections started the day after angiography. These differences could not be explained by differences in HL-A matching or the origin of the kidney. The findings indicate that angiography might elicite an acute rejection. A possible mechanism for starting this reaction might be activation of the complement system.

Angiography↗