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Biomedical subjects

M Hayden

Publications and source records attributed to M Hayden.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Silent periods, long-latency reflexes and cortical MEPs in Huntington's disease and at-risk relatives.

Short-latency (R1) and long-latency (R2) components of the stretch reflex, the electromyographic silent period (S-X interval) and motor evoked potentials (MEPs) elicited by magnetic stimulation of the cortex were measured in Huntington's disease (HD), at-risk first degree relatives and a normal control group. R1 and MEPs as well as central motor delay were normal in all 3 groups. R2 was absent in 7/9 patients with HD and 3/13 at-risk subjects. The S-X interval was reduced (less than 84 msec) in 7/9 patients and 5/13 at-risk subjects. Combined studies were abnormal in 88.9% of patients and 54% of at-risk subjects.

Adult↗
PubMedDate not supplied

Domestic violence in the emergency department: how do women prefer to disclose and discuss the issues?

The purpose of this study was to survey women presenting to the emergency department (ED) and determine from them how best to identify and discuss issues of domestic violence (DV). An anonymous 10-question survey was given to ambulatory females presenting to the ED. It was conducted at two affiliated university hospital EDs, one an urban trauma center (ED 1) and the other an ED in an affluent suburban setting (ED 2). Two hundred forty-three women responded (73% response), 153 (63%) from ED 1 and 90 (37%) from ED 2. There were 21 women (9%) currently being abused, and 109 (45%) were past victims. Of all victims, 40 (36%) would only divulge DV if asked directly, 28 (25%) would volunteer this information without being asked, and 12 (11%) would not report DV even if asked. Of women who would reveal DV only if asked directly, 52 (45%) felt very comfortable disclosing this to an ED physician, although only 27 (24%) would reveal DV at a triage encounter. Of past or current victims, 43 (39%) would not disclose DV if they knew that ED personnel were required to report it. In conclusion, the ED is an appropriate setting to discuss DV issues. A significant percentage of women will disclose DV only if asked directly about it. Many victims of DV feel very comfortable discussing DV with ED physicians and nurses, although they may be less likely to reveal DV incidents at a triage encounter. Mandatory reporting laws may be an impediment to identifying cases of abuse.

Adolescent↗
PubMedDate not supplied

High-resolution polyacrylamide gel electrophoresis of oligonucleotides using L-histidine buffer.

We have found that 50 mM L-histidine pH 7.6 as a buffer for gel electrophoresis greatly improves the resolution of oligonucleotides less than 70 residues long on denaturing polyacrylamide gels. The histidine buffer increases spacing between DNA bands on the gel about twofold in comparison with a standard buffer (89 mM Tris-borate, 2 mM EDTA pH 8.3). In addition, low conductivity of the histidine buffer results in a threefold reduction of the electrophoresis time. Conditions for electrophoresis were optimized by varying both histidine and acrylamide concentrations. Other polycationic compounds, such as spermidine and ethylenediamine, were also tested for improved resolution of oligonucleotides. Several hypotheses as to the factors influencing the separation of DNA on gels are presented.

Buffers↗