Biomedical subjects

M Haupts

Publications and source records attributed to M Haupts.

28 records · Page 2Linked to original sources

PubMed1989

[Acute postoperative psychosyndromes. A prospective study and multivariate analysis of risk factors].

The incidence of postoperative delirium was assessed in 92 patients on a general surgical intensive care unit. Postoperative delirium was diagnosed in 39 patients (42%). Most of the cases were diagnosed on the second postoperative day and the median duration was seven days. Ten patients with delirium (25%) had a lethal outcome, compared to a 13% mortality of the whole population. In univariate analysis the variables age, preoperative therapy for heart failure, respirator therapy, dobutamin therapy and lowest capillary pO2 on day one were significantly associated with later development of delirium, whereas preoperative peritonitis, and history of stroke or hypertension were only borderline significant. A predictive model with three parameters emerged from multiple logistic regression analysis: after correction for age (p = 0.001), respirator therapy (p = 0.020), and capillary pO2 on day one (p = 0.049) none of the remaining variables proved of additional significance. The statistical model yielded a predictive accuracy of 78%.

Adult↗

PubMed1988

Further aspects of MR-signal enhancements in stenosis of the cervical spinal canal. MRI-investigations in correlation to clinical and cerebrospinal fluid (CSF) findings.

The validity and anatomical basis of increased MR-signal intensity of the cord in cervical canal stenosis is discussed with respect to our own data of 32 patients (including results of clinical, CSF and other imaging technique findings) and previous reports. A shear-stress hypothesis with edematous tissue changes is favoured.

Humans↗

PubMed1988

[Metachromatic leukodystrophy. Results of laboratory chemical, neurophysiologic, histologic and imaging procedures within the scope of a family study].

Examining the members of a family the validity of chemical analysis, neurophysiology and neuroimaging for the diagnosis of metachromatic leukodystrophy (MLD) is discussed. As the arylsulfatase A is not decreased in all cases, the neuroimaging (cranial computerized tomography--at a less extend magnetic resonance imaging) gains a particular diagnostic significance. But neither for neuroimaging nor for neurophysiological findings the results are specific. The histological findings have to back up the diagnosis.

Adult↗

PubMed1987

[Differential diagnosis of juvenile stroke. A case of moyamoya].

Stroke before the age of 40 years is unusual and its etiology often different from that in older people. In a 29-year-old man the cause of a stroke was revealed to be bilateral vascular malformations at the base of the brain, an example of the moyamoya syndrome, rare among Europeans and published in German-speaking countries only in a few single case reports.

Adult↗

PubMed1987

The myelon in cervical spinal canal stenosis: imaging by X-ray and MRI.

Methods which produce findings relevant to diagnosis and therapy of cervical vertebral canal stenosis are described. Especially MRI provides insights into the structure of the myelon; abnormal image signals may possibly correlate with cervical myelopathy based on disorders of microcirculation.

Adult↗

PubMed1987

Cranial magnetic resonance imaging in multiple sclerosis--indicated only in exceptional cases?

Clinical examination, spinal fluid laboratory data, evoked potentials (EP), cranial computed tomography (CT), and magnetic resonance imaging (MRI) were compared for their value in diagnosing multiple sclerosis (MS) in 51 patients aged 18-60 yrs. MRI was superior to CT imaging: supratentorial lesions were found in 90% of the patients with confirmed MS. These lesions are not specific, however, as vascular processes, vitamin B12 deficiency or chronic encephalitis, can show similar MRI-patterns. The detection of infratentorial lesions in symptomatic patients was poor (8% compared to 64% pathological EP-findings). Thirty-eight patients (= 75%) could be classified correctly as "confirmed MS" according to Bauer-criteria without any CT or MR imaging. In the remaining 13 patients presenting classificatory problems due to normal CSF, first manifestation or possible alternate processes, MRI helped for the final diagnosis in only 6 cases. The value of MRI in diagnosing MS seems to lie in its superiority to CT in excluding other pathological processes or for research rather than in its value for the confirmation of the diagnosis. In a minority of cases, it can detect supratentorial lesions in patients with pure spinal symptoms, normal CSF, or first manifestations.

Brain↗

PubMed1987

Relationship of nuclear magnetic resonance examinations to clinical data, cerebrospinal fluid findings and visual evoked potentials in multiple sclerosis.

We examined 150 patients with a 0.5 Tesla MR system. Fourteen patients were excluded from the study, because, in addition to the clinical signs of multiple sclerosis, they showed other abnormalities (spinal canal narrowing, embolic disease, Vitamin B12 deficiency, etc.). The results of the 136 examinations were related to the duration of disease, index of impairment on Kurtkze's disability scale, the clinical course, and the CSF and VEP results. The MR studies were evaluated in a semiquantitative manner. Patients with a long duration of disease demonstrated more changes than did cases with a short course. We found more periventricular confluences and more white matter plaques in the centrum semiovale. In addition, more lesions were seen in patients with a severe course of disease. All patients with negative CSF results (n = 13) showed positive MR examinations, and vice versa, patients with positive CSF findings showed negative MR results (n = 5). First results of a follow-up study demonstrate that most abnormalities in MR are not related to the clinical course or therapeutical procedure.

Brain↗

PubMed1987

Magnetic resonance imaging (MRI), cranial computerized tomography (CCT), evoked potentials and cerebrospinal fluid (CSF) analysis in five patients with funicular myelosis.

Five Patients with vitamin B12 deficiency were examined by means of MRI, CCT, VEP, BAEP, EEG, and CSF. In 3 patients medianus-SEP and EMG/ENG were recorded as well. Partly, findings of MRI, CCT, VEP, BAEP, SEP, and CSF were similar to those in multiple sclerosis. This is not very surprising considering that the central nervous system lesions in vitamin B12 deficiency consist of disseminated demyelination. Because of this all these investigative techniques must be considered non-specific. Appraisal of findings is only possible in connection with the case history, clinical findings, and supplementary diagnostic measurements.

Antibodies, Anti-Idiotypic↗

PubMedDate not supplied

Post-mortem volume measurements of limbic system and basal ganglia structures in chronic schizophrenics. Initial results from a new brain collection.

Volumes of the hippocampal formation, external and internal pallidum, caudate, putamen, and nucleus accumbens were measured in both hemispheres of recently collected post-mortem brains of 18 chronically ill schizophrenics and 21 control subjects. In the schizophrenic group, the hippocampal formation and the internal pallidum were significantly smaller in the right and left hemisphere, whereas external pallidum, putamen, caudate and accumbens were not significantly changed. Volumes of the hippocampus and of all evaluated parts of the basal ganglia were in the male schizophrenics more reduced than in the female patients. The right and left hemispheres were equally affected in both sexes. Since the mean brain weight was in patients and controls nearly identical, the volume differences can not be explained by a general brain atrophy or hypoplasia but rather indicate a more focal lack of brain tissue, by which some clinical features of the disease might be explained.

Adult↗

PubMedDate not supplied

The cognitive-mnestic performance profile of a patient with bilateral asymmetrical thalamic infarction.

The case of a 46-year old patient with a bilateral medial thalamic infarct, affecting mainly the region of the internal medullary lamina, but not of the mammillothalamic tract, is documented neuropsychologically and neuroradiologically. Testing was done after acute remission. The patient was of average intelligence but manifested a number of verbal memory problems. These are most likely attributable to the selective diencephalic damage and are interpreted as a disconnection syndrome.

Cerebral Infarction↗